Item | Information |
---|---|
CAS RN | 10022-31-8 |
Chemical Name | Barium nitrate |
Substance ID | H28-B-004, C-007B |
Classification year (FY) | FY2016 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2007 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | It is a nitrate, which contains a chemical group associated with explosive properties. However, because it is classified in Division 5.1, PG II (UN1446) in UNRTDG, it does not correspond to explosives which is hazard class with higher precedence. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2004)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | It is a nitrate, which contains a chemical group associated with explosive properties, but it is classified in oxidizing solids. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2004)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2004)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of water solubility (8.7 g/100 mL (20 deg C), ICSC (2004)). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
14 | Oxidizing solids | Category 2 |
Danger |
H272 |
P370+P378
P210 P220 P221 P280 P501 |
It is written that it is a strong oxidant (ICSC (2004)). Moreover, because it is classified in Division 5.1, PG II (UN1446) in UNRTDG, it was classified in Category 2. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Based on the LD50 value of 355 mg/kg (EHC 107 (1990)) for rats, it was classified in Category 4. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that in a skin irritation test using rabbits (24-hour application though), mild irritation was observed (HSDB (Access on June 2016)). |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Based on a description that severe irritation was observed in an eye irritation test using rabbits (EHC 107 (1990)), it was classified in Category 2A. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There is no in vivo data. As for in vitro, the bacterial reverse mutation test was negative (CICAD 33 (2001), HSDB (Access on May 2016)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - |
There is no information on the carcinogenicity on this substance itself. However, as described in the same hazard class of the GHS classification for barium, the EPA classified barium and its compounds as Group D or NL (IRIS (1998)) and ACGIH classified barium and its soluble compounds as A4 (ACGIH (7th, 2001)) based on results of animal tests using barium chloride dihydrate. Therefore, this substance was also classified as "Classification not possible" based on the classifications by other organizations. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, cardiovascular system, muscular system, kidney, gastrointestinal tract), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
It is written that in humans, accidental or intentional ingestion of soluble barium compounds at high concentrations causes gastroenteritis (vomiting, diarrhoea, abdominal pain), hypokalemia, hypertension, cardiac arrhythmias, skeletal muscle paralysis and renal failure (CICAD 33 (2001), ATSDR (2007)). Moreover, as adverse effects from this substance by the oral or inhalation route, gastroenteritis (nausea, vomiting, diarrhoea), muscle spasm, slow pulse, extrasystoles, renal failure, and hypokalemia are reported. It is also reported that exposure may result in death (HSDB (Access on May 2016)). Additionally, irritation of the respiratory tract is reported. (HSDB (Access on May 2016)). From the above, it was classified in Category 1 (nervous system, cardiovascular system, muscular system, kidney, gastrointestinal tract), and Category 3 (respiratory tract irritation). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system, nervous system, muscular system, kidney) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There is no information on this substance. However, it is said that the toxicity of barium and barium compounds depends largely on the solubility, and that their toxicity is inhibitory effects on the potassium channel by the barium ions (ATSDR (2007)). Barium ions and soluble compounds of barium (notably barium chloride, barium nitrate, barium hydroxide) are toxic to humans. Although barium carbonate is relatively insoluble in water, it is toxic to humans because it is soluble in the gastrointestinal tract. The insoluble barium compounds (notably barium sulfate) are inefficient sources of barium ions and are therefore generally nontoxic to humans (ATSDR (2007)). Therefore, this substance is thought to exhibit a similar target organ as soluble barium compounds do. It is reported that incidences of hypertension, heart disease, and stroke increased in a population of neighborhood who ingested drinking water containing water soluble barium such as barium chloride, and that an increase in mortality due to heart diseases such as vascular disorder and arteriosclerosis was observed in other similar groups (ATSDR (2007)). As for the inhalation route, the increase in incidences of elevated blood pressure is reported among workers exposed to soluble barium (mean 1.07 g/m3) caused by blending and grinding of several grades of barium at mineral processing facilities (CICAD 33 (2001)). As for the effects of soluble barium compounds on humans: as acute effects, it is regarded that gastroenteritis (vomiting, diarrhoea, abdominal pain), hypopotassemia, hypertension, cardiac arrhythmias, and skeletal muscle paralysis may be caused by intake at high concentrations (CICAD 33 (2001)) Additionally, there are only several reported cases that renal failure and renal insufficiency occurred as acute barium poisoning. However, as for experimental animals, in 13-week or 2-year studies on barium dichloride or its dihydrate using rats or mice administered by drinking water, death cases attributed to nephropathy were observed at doses above Category 2 (converted guidance value as barium dichloride: 271-803 mg/kg/day) in both species. It is also described that the kidneys are the most sensitive target organ in the experimental animals (ATSDR (2007)). Therefore, it is thought that the kidneys are one of the target organs in also humans. From the above, the substance was classified in Category 1 (cardiovascular system, nervous system, muscular system, kidney) since it was thought that effects of soluble barium compounds including this substance might occur in the cardiovascular system, nervous system, muscular system and kidneys with high probability. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 24-hour LC50 = 9018 mg/L for crustacea (Artemia salina) (ECETOC TR 91, 2003), it was classified as "Not classified." |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Because it is not poorly water soluble (water solubility = 90000 mg/L, GESTIS, 2016), and is classified as "Not classified" for acute toxicity, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |