GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 13446-34-9
Chemical Name Manganese(II) chloride tetrahydrate
Substance ID H28-A-079, C-141A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on November 2016)).
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on November 2016)).
11 Self-heating substances and mixtures Not classified
-
-
- -  It is not combustible (GESTIS (Access on November 2016)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It contains a metal (Mn), but it is estimated that it does not react vigorously with water because the measurement result of water solubility 1,980 g/L were obtained (GESTIS (Access on November 2016)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not classified
-
-
- -  The substance is an inorganic compound containing oxygen and chlorine. Oxygen is from crystalline water, and chlorine is a chlorine ion, both of which do not contribute to oxidation.
15 Organic peroxides Classification not possible
-
-
- -  It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 Based on a report of an LD50 value of 7.5 mmol/kg (converted LD50 value with a molecular weight of 197.9: 1,484 mg/kg) (Holbrook DJ Jr. et al.: Environ Health Perspect., 10, 95 (1975)), this substance was classified in Category 4.
 As for the following health hazard classes, please refer to also manganese chloride (II) (CAS RN 7773-01-5), which is the anhydrous substance of this substance.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  As for in vivo tests, it was negative in chromosomal aberration tests using spermatogonial cells and bone marrow cells of rat (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), ATSDR (2012)). As for in vitro tests, positive and negative results were reported in bacterial reverse mutation tests; a mouse lymphoma test of cultured mammalian cells, and a chromosome aberration test of human lymphocyte cultured cells were positive (ATSDR (2012)). From the above, this substance was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- -  Data is not available for this substance itself. However, as the data on divalent soluble manganese compounds, there is a carcinogenicity test report by NTP, in which manganese sulfate monohydrate was administered in the diet to rats or mice for 2 years. There was no evidence of carcinogenicity in both male and female rats, but in mice, there was a slight increase in thyroid follicular cell adenoma in both males and females. It was concluded by NTP that the evidence of carcinogenicity was equivocal (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NTP TR428 (1993), CICAD 12 (1999), ATSDR (2012)).There is no classification result for manganese compounds by other organizations. Therefore, the classification of this substance for this hazard class was not possible due to lack of data.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
 In a test in which this substance was subcutaneously administered to pregnant mice (Gestation days 6 to 15), at doses in which suppression of maternal weight gain and reduction in feed intake were observed in maternal animals or even at lower doses, increased embryo resorptions, hypoplasia of the kidney, and wavy ribs were observed in the fetuses (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In a test in which manganese chloride was intravenously administered to pregnant rats during organogenesis (Gestation Days 6 to 17), fetal death, skeletal abnormality, wavy ribs, and bending of limbs were observed even at doses lower than that at which the maternal toxicity (suppression of body weight gain, implantation number reduction) was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In addition, it is also reported that increased exencephaly and embryo resorptions were observed in a single intraperitoneal administration of manganese sulfate to pregnant mice on the 8th day of gestation, and at higher doses, inhibition of implantation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, in a test in which manganese chloride was administered in the drinking water to pregnancy rats, throughout the pregnant period, even at doses exceeding the expression of maternal toxicity (suppression of body weight gain, decrease in water intake), low body weight of the offspring was the only observation seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
 As described above, although it is limited to some extent, the toxicity information of the divalent soluble manganese compounds including this substance showed skeletal abnormalities, external malformation, inhibition of implantation, etc. in the fetuses through injection routes such as subcutaneous, intravenous or intraperitoneal injection. Therefore, it was deemed appropriate to classify this substance in Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
 Although it is not regarding this substance, when humans are exposed to excess amounts of manganese, by the oral or inhalation route, effects such as memory disorders or psychiatric symptoms were observed as acute effects. As for chronic effects, symptoms of manganese addict similar to those of Parkinson's disease were seen, such as gait disturbance and language disorders. Serious effects were observed especially in inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for the oral route, in cases of drinking well water containing high concentrations of manganese, and in epidemiological investigations on residents living in regions with high manganese concentration, symptoms similar to manganese addiction symptoms such as mask-like faces, muscle rigidity, tremors and psychiatric disorders were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). The influence on the neurobehavioral function by exposure to the dust of manganese dioxide, trimanganese tetraoxide, and manganese salts (sulfate, carbonate, nitrate) at plants manufacturing manganese oxides and manganese salts were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Occurrence of neurotoxicity due to manganese poisoning has been reported as a result of occupational exposure to manganese dioxide. In addition to impaired visual reaction time and hand-eye coordination, rigidity of the hands has been observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). Furthermore, many cases revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)).
 As for experimental animals, it is reported that in a 60-day repeated dose toxicity test by gavage using young rats of 3 weeks of age, at doses of 0.31 mg/kg/day (converted guidance value: 0.21 mg/kg/day), which corresponds to Category 1, increased brain monoamine oxidase activity and neurodegeneration in the cerebellar and cerebral cortex and caudate nucleus were observed (ATSDR (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, in a 10-week toxicity test using rats dosed with this substance in the drinking water, at doses of 6.5 mg/kg/day, which is equivalent to Category 1, decreases in spatial memory performance, open field locomotor activity and acoustic startle response, and increased latency of sensory evoked potentials were reported (ATSDR (2012)).
 Therefore, this substance was classified in Category 1 (nervous system, respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
 From 72-hour ErC50 = 82 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
 Due to unknown environmental dynamics of the inorganic compound, and 21-day NOEC (reproduction) = 0.16 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)), it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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