GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 13814-96-5
Chemical Name Lead bis(tetrafluoroborate)
Substance ID H28-A-068, C-130A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Classification not possible
-
-
- -  No data available.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- -  No data available.
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It contains a metal (Pb), but it is estimated that it does not react vigorously with water due to the information that it is soluble in water and stable only in an aqueous solution (R.Lide (2010)).
13 Oxidizing liquids Classification not possible
-
-
- -  The substance is an inorganic compound containing halogen (F) (but not oxygen), but the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- -  No data available. Besides, there is the information of being corrosive to aluminum (HSDB (Access on September 2016)).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
 There is no information on this substance. Information on lead acetate, lead chloride, lead nitrate, and lead bromide was used for the classification. As for in vivo, positive results were observed in chromosomal aberration tests using mouse or rat bone marrow cells, micronucleus tests using rat bone marrow cells and sister chromatid exchange tests using mouse bone marrow cells. However, several of negative results also exist (IARC 87 (2006)). As for in vitro, positive results were observed in bacterial reverse mutation tests, gene mutation tests, and micronucleus tests using mammalian cultured cells. In addition to those test systems, several of negative results in chromosomal aberration tests also exist (IARC 87 (2006)). From the above, according to the GHS Classification Guideline for the Japanese Government, this substance was classified in Category 2.
6 Carcinogenicity Category 1B


Danger
H350 P308+P313
P201
P202
P280
P405
P501
 There is no data for this substance itself both in humans and experimental animals.
 However, IARC classified inorganic lead compounds in Group 2A as there is limited evidence in humans and sufficient evidence in experimental animals for the carcinogenicity of inorganic lead compounds (IARC 87 (2006)).
 In addition, ACGIH classified elemental lead as A3 and its inorganic compounds (ACGIH (7th, 2001)), the Japan Society For Occupational Health (JSOH) classified lead and compounds as Group 2B (Recommendation of Occupational Exposure Limits (2016)). From the above, it was decided that these classifications for inorganic lead compounds by other organizations should be adopted for this hazard class. According to the GHS classification guidance for the Japanese government in which evaluation by IARC is to be given preference, this substance was classified in Category 1B.
7 Reproductive toxicity Category 1A


Danger
H360 P308+P313
P201
P202
P280
P405
P501
 It is reported that a decrease in spermatologic parameters in male workers exposed to inorganic lead compounds in battery plants (blood lead levels is 40 microg/dL or lower) was observed, and lead is toxic to sperm and can alter the endocrine function in adults (NTP DB (Access on September 2016)). Moreover, lead crosses the placenta and is accumulated in fetal organs, including the brain. High level exposure to inorganic lead can induce intrauterine death and stillbirth (NTP DB (Access on September 2016)). Even at lower levels, prenatal exposure to lead causes decreased growth and delays in early infant development (NTP DB (Access on September 2016)). As the classifications by other organizations, EU classified this substance as Repr. 1A and designated it as SVHC (ECHA Annex XV dossier (Access on October 2016)). Moreover, the Japan Society For Occupational Health (JSOH) classified lead and compounds as Group 1 Reproductive toxicant (Recommendation of Occupational Exposure Limits (2016)). From the above, this substance was classified in Category 1A.
 Moreover, boric acid which is a boron compound (CAS RN 10043-35-3) is also found to have reproductive and developmental toxicity in experimental animals and is classified in Category 1B (FY2013 GHS classification).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, kidney)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
 There is no data on single exposure to this substance in humans or experimental animals. This substance is an inorganic lead compound, and there is information that this substance is soluble in water (IARC 87 (2006)). By ingesting the form of an aqueous solution, an inorganic lead compound forms ionized lead, and is considered to exhibit toxicity. In humans, apathy, restlessness, irritability, poor attention, headaches, muscular tremors, hallucinations, loss of memory, and nephropathy were reported as symptoms of acute toxicity of lead (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), ATSDR (2007), EHC 3 (1977)). From the above, this substance was classified in Category 1 (central nervous system, kidneys).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, haemal system, cardiovascular system, kidney)


Danger
H372 P260
P264
P270
P314
P501
 There is no data for this substance, but it is described that repeated exposure to high concentrations of lead results in irreversible changes in the kidneys, including renal tubular atrophy, interstitial fibrosis, glomerulus sclerosis, and ultimately chronic nephritis (IARC 87 (2006)). It is reported that in an epidemiological study on patients with lead poisoning, hemoglobin level and hematocrit value significantly decreased compared to unexposed matched controls (ATSDR (2007)). Lead inhibits delta-aminolevulinic acid dehydratase and heme synthesis enzyme, and induces microcytic anemia and hypochromic anemia through inhibition of heme synthesis and shortening of the erythrocyte lifespan (ATSDR (2007)). On the other hand, there is a study supporting a relationship between chronic lead poisoning and myocardial damage. It is reported that workers with lead poisoning have electrocardiographic changes (ACGIH (7th, 2001)). From epidemiological studies, it was concluded that lead absorption causes significant increase in both the systolic and diastolic blood pressure (ACGIH (7th, 2001)). In addition, a reduction in motor nerve conduction velocity was found in workers with elevated blood lead concentrations (ACGIH (7th, 2001)). Parkinsonian symptoms were observed in 7 of 9 persons exposed to lead batteries for not less than 30 years (NICNAS (2007)). From the above, this substance was classified in Category 1 (nervous system, haemal system, cardiovascular system, kidney).
 Additionally, it is described that this substance may cause fluorosis, and the symptoms including weight loss, malaise, anemia, leukopenia, discoloration of the teeth and osteosclerosis (HSDB (Access on September 2016)).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
 From 96-hour LC50 = 18 mg/L for fish (Pimephales promelas) (AQUIRE, 2016; Curtis and Ward, 1981), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
 Reliable chronic toxicity data were not obtained. Although environmental dynamics of the inorganic compound is unknown, and it is classified in Category 3 for acute toxicity, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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