GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 1317-38-0
Chemical Name Copper(II) oxide
Substance ID H28-A-062, C-121A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on August 2016)).
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on August 2016)).
11 Self-heating substances and mixtures Not classified
-
-
- -  It is not combustible (GESTIS (Access on August 2016)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (Merck (15th, 2013)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Classification not possible
-
-
- -  The substance is an inorganic compound containing oxygen, but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- -  It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on the report of an LD50 value (OECD TG 423) of >2,000 mg/kg (SIAP (2014)) for rats, this substance was classified as "Not classified."
1 Acute toxicity (Dermal) Not classified
-
-
- -  Based on the report on an LD50 value (OECD TG 402) of >2,000 mg/kg (SIAP (2014)) for rats, this substance was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, an LC50 value of >2.08 mg/L (EPA RED (2006)) for rats has been reported, but classification is not possible due to unknown exposure time.
2 Skin corrosion/irritation Not classified
-
-
- -  Mild irritation (PI Index 1.49) was observed in a rabbit skin irritation test (EPA RED (2009)), so this substance was considered to be "Not classified" (Category 3 in UN GHS classification). Also, it is reported that in a skin irritation test (OECD TG 404) using rabbits, it is not irritating (SIAP (2014)). Therefore, this substance was classified as "Not classified" (Category 3 in UN GHS classification).
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data. Additionally, in an eye irritation test using rabbits, although the details are unknown, there is a description that irritation was observed but resolved after 7 days (EPA RED (2009)). On the other hand, irritation was not observed in an eye irritation test (OECD TG 405) using rabbits (SIAP (2014)). Since conflicting data exists, this substance was classified as "Classification not possible."
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Category 1A


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
 According to the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016), copper and copper compounds are designated as Group 2 of occupational skin sensitizer, so this substance was classified in Category 1A. Additionally, a negative (no reaction at 48 hours after challenge) was reported in a skin sensitization test (OECD TG 406, maximization test) using guinea pigs (SIAP (2014)), and a negative was also reported in a skin sensitization test using guinea pigs (EPA RED (2009)), but it was not adopted as the evidence of the classification because the details are unknown.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity), Category 3 (respiratory tract irritation)



Danger
Warning
H370
H335
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
 It is described that, in humans, inhalation of fine dust particles of this substance can result in sneezing, coughing, digestive disorders and fever (DFGOT vol. 22 (2004)). It is also reported that metal fume fever accompanied with high fever, shivering, headaches, dryness in the mouth and throat, dysgeusia, nausea, shortness of breath, and myalgia occurred by acute inhalation exposure to copper fumes during the process of welding copper (DFGOT Vol. 22 (2004), Environmental Risk Assessment for Chemical Substances Vol.13 (Ministry of the Environment, 2015), HSDB (Access on September 2016)). This substance may also be contained in copper fumes. From the above, this substance was classified in Category 1 (systemic toxicity), and in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Additionally, in humans, according to health examination records (between 1970 and 1973) of workers (75 to 100 people) who engaged in the grinding and sieving processes of high purity copper at a copper smelting plant, 39 to 70% of the workers showed hepatomegaly, 10 to 15 % showed digestive disorders and 16% showed sexual impotence. It was reported that the copper concentration in the workplace ranged from 464 mg/m3 in 1971 to 111 mg/m3 in 1973. Using normal levels (0.8 - 1.2 mg/L) based on serum levels of copper (0.76-1.17 mg/L) in unexposed workers, it is reported that a rate of workers whose levels exceeded the normal ones increased from 40% to 92% in 1970-1973 (Environmental Risk Assessment for Chemical Substances Vol.13 (Ministry of the Environment, 2015), DFGOT Vol. 22 (2004), EHC 200 (1998)). However, it is described that since there is neither control group nor the description on methods for measuring exposure concentration, severely limit the usefulness (EHC 200 (1998)). Also as for experimental animals, although details are unknown, it was reported in a Russian report that, in a study using male rats exposed to copper oxide aerosol by inhalation for 90 to 100 days, decreases in hemoglobin concentration and serum protein concentration, testicular relative weight, sperm motility rate, and sperm viability were observed in the groups of 0.01 mg/m3 or above, and significant increases in red blood cell count were observed in the groups of 0.1 mg/m3 or above (Environmental Risk Assessment for Chemical Substances Vol.13 (Ministry of the Environment, 2015)).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From LC50 (unknown time) = 3.1 ppb for algae (Pseudokirchneriella subcapitata) (U.S. EPA: RED, 2009), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 Although environmental dynamics of the inorganic compound is unknown, due to NOEC (unknown time) = 0.2 ppb for algae (Pseudokirchneriella subcapitata) (US EPA: RED, 2009), it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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