GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 11103-86-9
Chemical Name Potassium dizinc(II) bis(chromate) hydroxide
Substance ID H28-A-056, C-115A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Not classified
-
-
- -  It is not combustible (ICSC(J) (2014)).
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is not combustible (ICSC(J) (2014)).
11 Self-heating substances and mixtures Not classified
-
-
- -  It is not combustible (ICSC(J) (2014)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It contains a metal (Cr), but it is estimated that it does not react vigorously with water because the measured water solubility data of 0.5 - 1.5 g/L was obtained (ICSC(J) (2014)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Classification not possible
-
-
- -  It is estimated that it is strongly oxidizing due to hexavalent chromium oxide, but the classification is not possible due to no test data on this substance.
15 Organic peroxides Not applicable
-
-
- -  It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Category 1B


Danger
H334 P304+P340
P342+P311
P261
P284
P501
 Chromium and its compounds are classified in Group 2 of occupational airway sensitizers in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016). This corresponds to Category 1A according to the GHS classification guidance for the Japanese Government. However, this substance was newly classified in Group 2 of occupational airway sensitizers as a substance which sensitization has not clarified yet through epidemiologic research, based on the classification standard for sensitization (provisional, May 26, 2010). Therefore, it was judged as inappropriate to classify this substance in Category 1A and it was classified in Category 1B.
4 Skin sensitization Category 1A


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
 Chromium and its compounds are designated as Group 1 of occupational skin sensitizers in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016). Also, it is known that dermatitis develops in workers handling products containing zinc chromate, and skin sensitization by zinc chromate is suggested (DFGOT Vol. 15 (1997)). From the above, this substance was classified in Category 1A.
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
 As for in vivo, a micronucleus test using mouse peripheral blood is positive.
 As for in vitro, a bacterial reverse mutation test is positive (NTP DB (Access on August 2016)).
 From the above, this substance was classified in Category 2 according to the GHS classification guidance for the Japanese Government.
6 Carcinogenicity Category 1A


Danger
H350 P308+P313
P201
P202
P280
P405
P501
 This substance corresponds to hexavalent chromium compounds and IARC classifies it in Group 1 (IARC 100c (2012)), ACGIH classifies it in A1 (ACGIH (7th, 2001)). Therefore, this substance was classified in Category 1A for this hazard class.
 Besides, EU classifies this substance in Carc. 1B, and designated it as SVHC (ECHA Support Document (2011)).
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
 There is no data available for this substance itself, but information on hexavalent chromium compounds is considered to be available for classification. Regarding reproductive effects of chromium (VI) in humans, there are reports on workers in metal plating factories in China, but there is no accurate description of the exposed period or exposure concentration, therefore, it is thought to be insufficient to be used as the evidence for reproductive toxicity (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014)).
 As for experimental animals, in an 18-month inhalation exposure test with the aerosol of sodium dichromate (Cr (VI) and chromium oxide (Cr (III)) mixed at a ratio of 3:2, effects on the testes were not observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014), CICAD 78 (2013)).
 As for oral route, in the study in which female rats were administered female rats were administered potassium dichromate in drinking water for 20-days before mating, and then mated with untreated males, the mating rate and conception rate decreased at doses of 38 mg/kg Cr (VI)/kg/day or more, and decrease in the number of corpus luteum, a reduction in implantation number and increase in preimplantation embryo loss number were observed at 70 mg Cr (VI)/kg/day or more (CICAD 78 (2013)).
 In addition, in a study in which potassium dichromate was administered to male and female mice for 12 weeks, mating with non-treated male and female mice, in both the dosed male group and dosed female group, decrease in the implantation number and the number of surviving fetuses were observed at 6 mg/kg Cr(VI)/kg/day or more, and as for the dosed male group, a decrease in the seminal vesicles and the preputial gland weight was observed, and as for the dosed female group, an increase in ovary relative weight was observed (CICAD 78 (2013)). On the other hand, in tests in which potassium dichromate was administered in the diet to rats or mice, no effect was observed in reproductive organs (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014), CICAD 78 (2013)). Thus, as for the effects on reproductive of hexavalent chromium compounds in experimental animals, there are both negative and positive results reported.
 Japan Society For Occupational Health (JSOH) had determined that the epidemiological investigations in humans are inadequate as evidence of classification, and in animals studies with hexavalent chromium compounds, reproductive and developmental toxicity was observed when administered by drinking water, but not observed when administered by feeding, and it could not be said that there is clear evidence of reproductive toxicity in animals studies. Therefore, Japan Society For Occupational Health (JSOH) classified chromium and chromium compounds in Group 3 of reproductive toxicity (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014), Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016)).
 From the above, based on the information on hexavalent chromium compounds, mainly, it was judged appropriate to classify this substance in Category 2 for this hazard class.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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