GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 10101-53-8 |
| Chemical Name | Chromium(III) sulfate |
| Substance ID | H28-A-052, C-111A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2016)). |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group present in the molecule associated with self-reactive properties (S=O), the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2016)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2016)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Cr), but it is estimated that it does not react vigorously with water because the measured water solubility data of 64g/100 g was obtained (R.Lide (2010)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Category 1B |
 Danger |
H334 |
P304+P340
P342+P311 P261 P284 P501 |
Chromium and its compounds are designated as Group 2 of airway sensitizer (Recommendation of Occupational Exposure Limits vol. 58 (Japan Society For Occupational Health, 2016)). This corresponds to Category 1A according to the GHS classification guidance for the Japanese Government. According to the GHS classification guidance for the Japanese Government (2013 revised edition), however, in the above recommendation, chromium and chromium compounds were newly designated as Group 2 for Respiratory Sensitization as a substance which sensitization has not clarified yet through epidemiologic research, based on the classification standard for sensitization (provisional, May 26, 2010), thus, it was judged as inappropriate to classify this substance in Category 1A. Therefore, the substance was classified in Category 1B. |
| 4 | Skin sensitization | Category 1A |
 Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
Chromium and its compounds are designated as Group 1 of skin sensitizer (Recommendation of Occupational Exposure Limits vol. 58 (Japan Society For Occupational Health, 2016)). Moreover, although details on test method, etc. are unknown, in a skin sensitization test using guinea pigs, skin reaction was observed and positive result was reported (CICAD 76 (2009)). Therefore, the substance was classified in Category 1A. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Trivalent chromium compounds are classified as Group 3 by the IARC carcinogenicity assessment (IARC 49 (1990)), A4 by ACGIH (ACGIH 7th (2001)) and Group D by EPA (IRIS (1998)). Therefore, the substance was classified as "Classification not possible." |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in a 7-week repeated dose toxicity study using mice given by feeding, it is reported that a significant decrease in spermatogonia and significant increase in pachytene stage cells in testis and a decrease in epididymal sperm count were observed in the group of 0.01% or above (converted guidance value: 8.2 mg/kg/day). Also, it is reported that an increase in the incidence of sperm morphological abnormality was observed in the group of 0.04% or above (converted guidance value: 33 mg/kg/day) (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)). However, in this report, it is pointed out that the description of the study method is insufficient and that the chromium compounds used for this study are unclear (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)). Therefore, the information was not adopted for the evidence of classification. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 |
P273
P391 P501 |
From 48-hour LC50 = 0.03 mg/L for crustacea (Daphnia magna) (AQUIRE, 2016; HSDB, 2016), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. Because environmental dynamics of the inorganic compound are unknown, and it is classified in Category 1 for acute toxicity, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |