| Item | Information |
|---|---|
| CAS RN | 28699-88-9 |
| Chemical Name | Dichloronaphthalene |
| Substance ID | H28-A-045, C-097A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described in CICAD 34 (2001) that the mortality rate on observation for 7 days after administration of 500 mg/kg of dichloronaphthalene (CAS RN not indicated) in rabbits was 0 %. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in repeated application tests of dichloronaphthalene (position of chlorine unknown) on rabbits, primary irritant dermatitis resulted within 24 hours following a single application (CICAD 34 (2001)). Also, strong dermal irritations are reported in guinea pigs dermally exposed to polychloronaphthalenes (CICAD 34 (2001)), however, it was not adopted because the irritation was not identified as attributed to this substance. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, irritation of the eyes is reported in workers exposed to polychloronaphthalenes, however, since it is also noted that there was possible exposure to other chemicals (CICAD 34 (2001)), it was not adopted. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There are no data on single exposure to this substance in humans and experimental animals. Besides, there are descriptions that chlorinated naphthalenes exhibit hepatotoxicity (CICAD 34 (2001), DFGOT Vol. 13 (1997)) and that symptoms in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headaches, anaemia, haematuria, anorexia, vomiting, and severe abdominal pain etc. (CICAD 34 (2001)), but there is no information on the number of exposures. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There was no information with regard to this substance. Besides, for humans, both severe skin reactions (chloracne) and liver disease have been reported in occupational exposure to chlorinated naphthalenes (CICAD 34 (2001), DFGOT vol. 13 (1997), ACGIH (7th, 2001)). It is reported that the toxicity varies depending on the amount of chlorination, and that studies in humans and animals had shown that toxicity was dependent on the congener/isomer, and that there is agreement in all studies that the penta- and hexa- isomers were the most toxic (CICAD 34 (2001)). With regard to effects on the skin, it is reported that chloracne was observed with trichloronaphthalenes and higher chlorinated naphthalenes (DFGOT vol. 13 (1997)). It is reported that in the case of chloracne from use of trichloronaphthalene (usually mixed with some tetrachloronaphthalene), the incidence and severity were less than chloracne produced by penta- and hexachloronaphthalene (ACGIH (7th, 2001)). It is reported that in wire manufacturing plants, contact with the fabric impregnated with pentachloronaphthalene and hexachloronaphthalene caused chloracne (ACGIH (7th, 2001)). Moreover, it is reported that in dermal application test to volunteers, chloracne was caused by only Halowax 1014 containing penta- and hexachloronaphthalenes and was not caused by Halowaxes containing mono-, di-, tri-, tetra-, hepta-, and octachloronaphthalene (CICAD 34 (2001)). With regard to the effects on the liver, as information in which the substance is identified to some extent, a non-fatal case of hepatitis induced by occupational exposure to trichloronaphthalene (tetrachloronaphthalene was probably also present (CICAD 34 (2001))) at 3mg/m3 has been reported (ACGIH (7th, 2001)). On the other hand, as for higher chlorinated congeners, it is reported lethality due to yellow atrophy of the liver was observed in a working environment of a mixture of pentachloronaphthalene and hexachloronaphthalene with a high chlorination number at a concentration of 1 to 2 mg/m3 (ACGIH (7th, 2001)). As for information for experimental animals, it is reported that in medium-term toxicity tests performed with technical mixtures of polychloronaphthalenes in rats and guinea pigs, liver damage (mainly enlarged liver cells with increased granularity and vacuolization) etc. was found, but the higher chlorinated mixtures seem to be more toxic (CICAD 34 (2001)). As described above, the effects on the liver and skin were caused by chlorinated naphthalenes, and pentachloronaphthalene which have five chlorine atoms and hexachloronaphthalenes which have six chlorine atoms are thought to be the major causal substances for the toxicity of chlorinated naphthalenes. However, the substance was classified as "Classification not possible" since it is not possible to conclude that this substance which has two chlorine atoms does not have any effect. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |