GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 513-79-1 |
| Chemical Name | Cobalt(II) carbonate |
| Substance ID | H28-A-038, C-088A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on July 2016)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on July 2016)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on July 2016)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Co), but it is estimated that it does not react vigorously with water because the water solubility data of 1.1 g/L was obtained (GESTIS (Access on July 2016)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not halogen) which is ionically bonded to the element other than carbon or hydrogen (Co) and does not contribute to oxidation. |
| 15 | Organic peroxides | Not applicable |
- |
- | - |
It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
This substance was classified in Category 4, based on the report of LD50 values of 317 mg/kg (CICAD 69 (2006), ATSDR (2004)) and 640 mg/kg (HSDB (Access on July 2016)) for rats. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Category 1A |
 Danger |
H334 |
P304+P340
P342+P311 P261 P284 P501 |
According to the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015), cobalt and its compounds are listed in Group 1 of occupational sensitizers to the airways. Therefore, this substance was classified in Category 1A. |
| 4 | Skin sensitization | Category 1A |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
According to the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015), cobalt and its compounds are listed in Group 1 of occupational sensitizers to the skin. Therefore, this substance was classified in Category 1A. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Category 2 |
Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
There are no test results for this substance itself. Cobalt and cobalt compounds are classified in Group 2B by IARC (IARC 52 (1991)), A3 by ACGIH (ACGIH (7th, 2001), Group 2B by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits, 2015) and R by NTP (NTP RoC (14th, 2016)). Therefore, this substance was classified in Category 2. Moreover, the EU classified this substance as Carc. 1B and designated this substance as SVHC (ECHA (2011)). |
| 7 | Reproductive toxicity | Category 1B |
Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
Although there is no information on the reproductive effects of this substance itself, it is considered that the information regarding inorganic cobalt compounds were considered available for the classification. In a test in which cobalt chloride hexahydrate was fed to male rats (265 ppm: 20 mg Co/kg/day), moderate to severe congestion appeared in the testes after administration for 35 days; and significant effects on the spermatogonial cells, spermatocytes and sperm cells were observed in addition to degenerative or necrotic changes in the germinal epithelium of the testes and Sertoli cells after administration for 70 days (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). In a test where male mice given cobalt(II) chloride in drinking water 12 weeks were mated with unexposed females, decreases were observed in the epididymal sperm count and in the survival of newborn pups at doses of 200 mg/L or higher. At doses of 400 mg/L or higher, the number of pregnant animals was reduced (declining fertility of males), testis weights decreased, and testicular sperm counts and daily sperm production decreased. Also, in a tissue observation of the testes, hypertrophy of the interstitial Leydig cells, congested blood vessels, degeneration of the spermatogonial cells, necrosis of the seminiferous tubules and interstitial tissue etc. were observed at doses of 400 mg/L or higher (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment) (2013), CICAD 69 (2006)). In another study in which pregnant rats were administered cobalt sulfate by gavage (gestation day 1 to 21), from the 50 mg/kg/day dose level, which is lower than the level of maternal toxicity expression (at 100 mg/kg/day, relative weight decrease of the liver, adrenal glands or spleen were observed), fetuses were reported to have malformations (malformations of the cranium, spinal column, renal pelvis, renal tubules, ovaries, and testis). It was also reported that in orally administered pregnant mice (gestation days 6 to 15), at 50 mg/kg/day, malformations of eyelids, kidneys, cranium, and spine occurred in fetuses (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment) (2013)). From the above, for inorganic cobalt compounds, harmful effects on the male genetic organs and consequent reduction in fertility by the oral route, and teratogenicity observed at dose levels without the maternal toxicity were reported. This substance is also an inorganic cobalt compound, and it is considered that similar reproductive and developmental toxicities are likely to occur. Therefore, this substance was classified in Category 1B. Moreover, EU had classified this substance in Repr. 1B along with other soluble cobalt compounds such as cobalt sulfate and cobalt dichloride, and designated this substance as SVHC (ECHA (2011)). |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There is no data on single exposure tests in humans or experimental animals for this substance. As for metallic cobalt (CAS RN 7440-48-4), it is reported that it shows respiratory tract irritation in humans (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), OEL Documentations (Japan Society For Occupational Health (JSOH), 1992), IARC 86 (2006), PATTY (6th, 2012)). The solubility of this substance in water is as low as 1.8g/L (CICAD 69 (2006)), so this substance will possibly show the same effects as insoluble metallic cobalt. Therefore, this substance was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs, haemal system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
It is described that the solubility of this substance in water is 0.18 g/100 g water (CICAD 69 (2006)). There is no available toxicity information with obvious exposure to this substance itself, in humans or in experimental animals. There is information below regarding the health effects of cobalt and cobalt compounds in humans. This may be applied to the hazard assessment of this substance. There is a report on diamond polishers exposed to airborne cobalt. Their chief complaints were symptoms in their respiratory organs, such as coughs; and adverse effects on lung function (significant decreases in the forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and maximal mid-expiratory flow rate (MMEF)) were reported as the cases (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), CICAD 69 (2006), ACGIH (7th, 2001)). As for workers in cobalt refineries, it was reported that skin lesions (eczema, erythema), respiratory symptoms (dyspnea, wheezing, chronic bronchitis), decreased pulmonary function, anemia (decreases in red blood cell count, hemoglobin level, and hematocrit value), and effects on thyroid function (slightly low T3 values) were observed (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), CICAD 69 (2006), ACGIH (7th, 2001)). Among the symptoms listed above, skin lesions were thought to be due to skin sensitivities, and the effects on the thyroid were only slightly low T3 values. These were therefore deemed to be non-target findings of specific target organs. From the above, it is considered appropriate to apply the effects of repeated exposure to cobalt and cobalt compounds in humans as those of repeated exposure to cobalt(II) carbonate. Therefore, this substance was classified in Category 1 (respiratory organs, haemal system). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 96-hour LC50 > 1000 mg/L for fish (Fundulus heteroclitus) (CICADs 69, 2006), it was classified as "Not classified." |
| 11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Because it is not poorly water soluble (water solubility = 1000000 mg/L, PHYSPROP Database 2009), and is classified as "Not classified" for acute toxicity, it was classified as "Not classified." |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |