GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 68937-41-7 |
| Chemical Name | Tris(isopropylphenyl) phosphate |
| Substance ID | H28-A-034, C-081A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified |
- |
- | - | A flash point is > 200 deg C (GESTIS (Access on May 2016)). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the water solubility result of 0.33 mg/L (20 deg C) measured (GESTIS (Access on June 2016)). |
| 13 | Oxidizing liquids | Classification not possible |
- |
- | - | No data available. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 value of >5,000 mg/kg for rats (HSDB (Access on June 2016)), the substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Based on the LD50 value of >2,000 mg/kg for rats (HSDB (Access on June 2016)), the substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | In skin irritation test using rabbits exposed for 4 hours under a semi-occlusive wrap, no irritation was reported (HSDB (Access on June 2016)). However, the substance was classified as "Classification not possible" due to lack of detailed information. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | In eye irritation test in rabbits, no irritation was reported (HSDB (Access on June 2016)), however, the substance was classified as "Classification not possible" due to lack of detailed information. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There is no single exposure data of this substance on humans and mammals. Besides, in single oral dose tests using hens, it is reported that the test substance inhibited neurotoxic esterase and that ataxia and neuropathological lesions were observed in a part of hens at high doses (3,000 to 9,000 mg/kg) (HSDB (Access on June 2016). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (nervous system) |
 Warning |
H373 |
P260
P314 P501 |
As for humans, it is reported that in 4 out of 8 male employees who exposed with this substance, electromyogram abnormalities were observed (HSDB (Access on June 2016)). It is reported that one male worker exposed by the dermal route for 2 years to this substance developed weakness and paresthesia in his hands, and his nerve conduction velocity was reduced (HSDB (Access on June 2016)). On the one hand, it is reported that at the production plant of this substance, as a result of clinical neurological examination including nerve conduction velocity tests conducted on 52 men and 8 women who were exposed and on 39 men and 14 women who were not exposed, no effects were observed (HSDB (Access on June 2016)). As for experimental animals, it was reported that in a repeated dose toxicity study using rats administered by dermal, although the degree is unknown, plasma cholinesterase activity and erythrocyte cholinesterase activity, etc. were inhibited (HSDB (Access on June 2016)). As above, electromyogram abnormality, muscle weakness, paresthesia, a decrease in nerve conduction velocity in humans were reported, but the substance was classified in Category 2 (nervous system) because these results were obtained from sources in List 2 in the GHS classification guidance for the Japanese government. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, from numerical data described in GESTIS (Access on June 2016) (viscosity: 37.6 mPa*s (35 deg C), density: 1.168 g/cm3 (20 deg C)), kinematic viscosity of this substance is calculated as 32.4 mm2/s (35/20 deg C) . |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |