GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 40088-47-9
Chemical Name Tetrabromodiphenyl ether
Substance ID H28-A-028, C-074A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Classification not possible
-
-
- -  No data available.
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- -  No data available.
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Since no data are available for carcinogenesis evaluation in both humans and experimental animals, and EPA classified this substance as Category D (IRIS Summary (1990)). Therefore, this substance was classified as "Classification not possible" for this hazard class.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, it was reported that several isomers of this substance were detected as one component of many congeners of polybromodiphenyl ether (PBDE) in breast milk of healthy women (HSDB (Access on June 2016)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 1 (genetic organs (men), central nervous system)


Danger
H372 P260
P264
P270
P314
P501
 No data are available for humans.
 As for experimental animals, in an 8-week repeated dose toxicity study using rats given by gavage, a decrease in serum testosterone, an increase in the number of multinucleated giant cells in the testis and an increase in the number of apoptotic cells were observed at 0.03 mg/kg/day (converted guidance value: 0.02 mg/kg/day), which is equivalent to Category 1, and reduction of sperm production and vacuolar spaces in the seminiferous epithelium were observed at 1 mg/kg/day (converted guidance value: 0.5 mg/kg/day) (ATSDR draft (2015)). Also, in a 30-day repeated dose toxicity study using mice given by gavage, effects on the testes (germ cell loss and increased apoptosis) were also observed at 0.045 mg/kg/day (converted guidance value: 0.015 mg/kg/day), which is equivalent to Category 1 (ATSDR draft (2015)). Moreover, in a 30-day repeated dose toxicity study dosed by gavage in rats, effects on the central nervous system (impaired learning and memory, decrease in the density of glutamate receptor in the hippocampus) were reported at 0.1 mg/kg/day (converted guidance value: 0.03 mg/kg/day), which is equivalent to Category 1 (ATSDR draft (2015)). Therefore, the substance was classified in Category 1 (genetic organs (men), central nervous system).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From 48-hour EC50 = 0.014 mg/L for crustacea (Daphnia magna) (NICNAS, 2001), it was classified in Category 1. It is considered in NICNAS that acute toxicity data for crustacea could be affected by physical effect such as immobilisation which absorption of test substance caused, but it was not evaluated as unreliable data. Therefore, the classification was conducted using the data.
 Besides, the data on Daphnia magna in NICNAS was from the test of a mixture of tri-, tetra-, penta-, and hexa-forms, but the data was used for the classification because toxicity values were not obtained for a single substance.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 If chronic toxicity data are used, then it is classified in Category 1 due to beindg not rapidly degradable (BIOWIN), and ELS NOEC = 0.0089mg/L for fish (Oncorhynchus mykiss) (NICNAS, 2001).
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 48-hour EC50 = 0.014 mg/L for crustacea (Daphnia magna) (NICNAS, 2001).
 It was classified in Category 1 from the above results.
 Besides, the data on Oncorhynchus mykiss and Daphnia magna in NICNAS were from the test of a mixture of tri-, tetra-, penta-, and hexa-forms, but the data was used for the classification because toxicity values were not obtained for a single substance.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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