GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 103-71-9 |
| Chemical Name | Phenyl isocyanate |
| Substance ID | H28-A-012, C-049A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Due to a flash point of 51 deg C (closed cup) (ICSC(J) (2002)), it was classified in Category 3. It was classified in Division 6.1, Subsidiary Risk 3, PG I (UN2487) in UNRTDG. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 300 deg C (ICSC(J) (2002)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen in the molecule. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Based on the LD50 value of 940 mg/kg for rats (ACGIH (7th, 2015)), it was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the LD50 value of 7,130 mg/kg for rabbits (ACGIH (7th, 2015)), it was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
 Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on the LC50 (4 hours) value of 4.6 ppm for rats (converted value: 0.022 mg/L) (ACGIH (7th, 2015)), it was classified in Category 1. Since the LC50 value was lower than 90% of the saturated vapor pressure concentration (3,391.89 ppm, converted value: 16.53 mg/L), the reference values in the unit of ppm was applied as vapour without mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Asthma-like symptoms were observed due to various chemicals including this substance (DFGOT Vol.17 (2002), HSDB (Access on June 2016)). In an inhalation exposure study with this substance using rats, effects on the respiratory system were observed (DFGOT Vol.17 (2002), HSDB (Access on June 2016)). |
| 4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
A maximization test using guinea pigs was positive (30% or more of animals were positive) (DFGOT Vol.17 (2002)). Therefore, it was classified in Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, a micronucleus test and a chromosomal aberration test using the bone marrow of mice were negative (ACGIH (7th, 2015), HSDB(Access on June 2016)). As for in vitro, the results of bacterial reverse mutation tests were positive and negative (ACGIH (7th, 2015). Therefore, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. It is reported that no embryotoxicity was seen when a single oral dose of 10 mg/kg was given to pregnant mice on gestation days of 4, 7, 11 or 15 (ACGIH (7th, 2015)). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
 Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
There are no single exposure data for this substance in humans. In an acute toxicity test using rats, the LC50 value for a single 4-hour inhalation exposure was 4.6 ppm (converted value: 0.022 mg/L), and this value was within the guidance value range for Category 1 (ACGIH (7th, 2015)). Also, it is described that, based on clinical signs and gross pathology, lung was considered to be a target organ (ACGIH (7th, 2015)). Therefore, it was classified in Category 1 (respiratory organs). Besides, it is reported that in the other study using rats exposed to a saturated vapor pressure concentration of this substance (approximately 1600 ppm) for 3, 10 and 30 minutes, all the rats died due to the single inhalation exposure, and nasal irritation in the observation until the time of death, and the pulmonary damage in the necropsy after death were observed (ACGIH (7th, 2015). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There is no information on humans. In a 2-week inhalation toxicity study in rats (6 hours/day, 5 days/week, 10 times of exposure), the effect on the respiratory organs (Goblet cell hyperplasia in the nasal and paranasal cavity and main bronchi, changes in pulmonary function tests etc.) were reported at 4.1 mg/m3 which is equivalent to Category 1 (converted guidance value: 0.0005 mg/L) or more (DFGOT Vol.17 (2002), ACGIH (7th, 2015)). Therefore, it was classified in Category 1 (respiratory organs). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |