GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 375-95-1
Chemical Name Perfluorononanoic acid
Substance ID H28-A-011, C-033A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- -  No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  The substance is an organic compound containing oxygen and fluorine (but not chlorine) which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  As for in vivo, a micronucleus test using rat bone marrow was negative (NTP DB (Access on June 2016)). As for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on June 2016)).
 From the above, this substance was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, in a Swedish epidemiological study examining a possible association between the exposure to perfluoroalkyl compounds and the onset of prostate cancer, it is described that increases in the risk of prostate cancer were not associated with levels of this substance in serum (draft ATSDR (2015)).
7 Reproductive toxicity Classification not possible
-
-
- -  It is described in an epidemiological study examining the possible association between the exposure to perfluoroalkyl compounds and the occurrence of endometriosis among 373 women who lived in the United States that significant associations were found between the levels of this substance and perfluorooctanoic acid (PFOA) in serum and endometriosis (the odds ratios, after adjustment for ages and BMI, were PFOA 1.89 (95% CI 1.17–3.06) and this substance 2.20 (95% CI 1.02–4.75)) (draft ATSDR (2015)). It is also described that numerous perfluoroalkyl compounds, including this substance, PFOA, and perfluorooctanesulfonic acid (PFOS), were detected in breast milk samples (draft ATSDR (2015)).
 From the above information, this substance is potentially considered to have toxicity similar to PFOA and PFOS. However, data for this substance are extremely limited, especially data of experimental animals are missing, and no evidence of developmental toxic effects including malformations was obtained, unlike PFOA and PFOS.
 Therefore, although it is possible that this substance is also a potential reproductive toxicant as a perfluoro-compound, the evidence was insufficient. Thus, at this point, classifying the substance as "Classification not possible" was judged to be reasonable due to lack of data.
 Besides, the EU classified this substance as "Repr. 1B" and designated it as an SVHC (ECHA Inclusion of substances of very high concern (Access on May 2016)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 1 (genetic organs (women))


Danger
H372 P260
P264
P270
P314
P501
 It is described in an epidemiological study examining a possible association between the occurrence of endometriosis and exposure to perfluoroalkyl compounds among 373 women living in the United States that significant associations were found between endometriosis and levels of this substance and perfluorooctanoic acid (PFOA) in serum (the odds ratios, after adjustment for age and BMI, were PFOA 1.89 (95% CI 1.17–3.06) and this substance 2.20 (95% CI 1.02–4.75)) (draft ATSDR (2015)).
 Therefore, this substance was classified in Category 1 (genetic organs (women)).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  Although 72-hour EC50 = 497 mg/L for algae (Chlorella vulgaris) (AQUIRE, 2016, Latala et al., 2009) and 48-hour EC50 = 151 mg/Lfor crustacea (Daphnia magna) (AQUIRE, 2016, Ding et al., 2012), because appropriate data on water solubility were not obtained, it was classified as "Classification not possible" not as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  Because appropriate information on water solubility and bioaccumulation was not obtained, it was classified as "Classification not possible."
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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