GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 3864-99-1
Chemical Name 2,4-Di-tert-butyl-6-(5-chloro-2H-1,2,3-benzotriazol-2-yl)phenol [UV-327]
Substance ID H28-A-009, C-031A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives Classification not possible
-
-
- -  There is a chemical group associated with explosive properties (neighboring nitrogen atoms) present in the molecule, but the classification is not possible due to no data.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  No data available.
8 Self-reactive substances and mixtures Classification not possible
-
-
- -  There is a chemical group associated with explosive properties (neighboring nitrogen atoms) present in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- -  No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- -  No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It is estimated that it does not react vigorously with water because water solubility (0.026 mg/L) was measured (ECHA (2013)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  The substance is an organic compound containing oxygen and chlorine which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Not classified
-
-
- -  No effects on parental fertility and no adverse effects on offspring were observed in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats administered by gavage at doses up to 1,000 mg/kg/day (JECDB (Access on May 2016)). Moreover, in developmental toxicity test by gavage with rats during the organogenesis period of pregnancy, no developmental effects including maternal toxicity and teratogenicity to the fetus were observed up to 1,000 mg/kg/day (JECDB (Access on May 2016)). Therefore, the substance was classified as "Not classified" for this hazard class according to the GHS classification guidance for the Japanese government.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  There is no information on humans.
 As for experimental animals, in a 28-day combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using rats administered by gavage, an increase in the absolute and relative liver weight, a shortening in the activated partial thromboplastin time and a decrease in albumin/globulin ratio etc. were observed in male rats at 25 mg/kg/day (converted guidance value: 7.8 mg/kg/day) or more, which is equivalent to Category 1. A decrease in the erythrocyte count, an increase in the amount of neutrophils, an increase in the amount of alkaline phosphatase and a decrease in total bilirubin were observed in male rats dosed at 250 mg/kg/day (converted guidance value: 77.8 mg/kg/day), which is equivalent to Category 2 (JECDB (Access on May 2016)).
 As described above, also findings suggesting effects on the liver were observed, however, data are not sufficient for the evidence of the classification. Moreover, death nor suppression of body weight gain etc. was not observed at up to the highest dose. From the above, it is thought that it is not possible to classify from these test results.
 Therefore, this substance was classified as "Classification not possible."
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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