GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 20661-21-6 |
| Chemical Name | Indium(III) hydroxide |
| Substance ID | H28-A-002, C-004A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result that it was not miscible with water (Santa Cruz Biotechnology SDS (2011)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that indium and its compounds were irritant to the skin (HSDB (Access on June 2016)). However, the information source was listed as List 2 and the original article was not able to be confirmed, therefore, the information was not adopted as the evidence for classification. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. It is described that indium is irritant to the eyes and respiratory system, and that it causes cough and shortness of breath through inhalation (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), but the information was judged not to be applicable to this substance and was not adopted as the evidence for classification. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data were available on this substance itself. The substance is an insoluble compound. For insoluble indium compounds, no in vivo data are available, and as for in vitro, bacterial reverse mutation tests and in vitro mammalian cell chromosome aberration tests were negative for indium, and bacterial reverse mutation tests were negative for indium oxide (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). Therefore, this substance was classified as "Classification not possible" due to lack of data. |
| 6 | Carcinogenicity | Category 1B |
 Danger |
H350 |
P308+P313
P201 P202 P280 P405 P501 |
No data were available regarding carcinogenicity of this substance itself. However, as described in the hazard class of classification result of indium oxide (CAS No. 1312-43-2), for the classifications by other organization of related compounds, IARC classified indium phosphide as Group 2A (IARC 86 (2006)), The Japan Society For Occupational Health (JSOH) classified hardly soluble inorganic indium compounds as Group 2A (Recommendation of Occupational Exposure Limits (2015)). This substance is also insoluble and it was considered that this substance was able to be classified based on the above classifications by other organizations. Therefore, the substance was classified in Category 1B. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described that indium is irritating to the respiratory system in Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013). However, the information source was ICSC and the original article could not be confirmed. Also, it was not clear whether the description was regarding only indium metal or indium compounds. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
No data regarding this substance was available. However, regarding indium oxide, which is an insoluble indium compound as is this substance, in a 13-week inhalation study using rats, effects on the lungs (infiltration of alveolar macrophages, alveolar proteinosis, alveolar epithelial hyperplasia etc.) were observed at 1 mg/m3 (Converted guidance value: 0.00072mg/L), which is equivalent to Category 1. On the other hand, for the oral route, in a 3-month administration toxicity test using rats by feeding, no toxic effects were observed even at a dose equivalent to 4,000 mg/kg/day (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). Although not indium oxide alone, as for the case reports of workers who were engaged in the manufacture of liquid crystal thin film materials, there was a case of a worker who handled mainly indium oxide as well as various other metals such as tin, zinc, aluminum, antimony, etc., that although a combined effect with other metals could not be denied, it was considered to be interstitial pneumonia caused by the inhalation of indium oxide (Environmental Risk Assessment for Chemical Substances, Vol. 11 (Ministry of the Environment, 2013), OEL Documentations (Japan Society For Occupational Health (JSOH) ,2007). As described above, although there was no information on this substance, this substance was considered to indicate the similar effect on the lungs to indium oxide, which is also an insoluble substance. Therefore, this substance was classified in Category 1 (respiratory organs). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |