GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 13464-82-9 |
| Chemical Name | Indium(III) sulfate |
| Substance ID | H28-A-001, C-003A |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of water solubility (117 g/1,000 g (20 deg C), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, an LDLo value of 1,200 mg/kg for rats was reported (PATTY (6th, 2012)) and this value suggests Category 4 or above, however, the classification is not possible only from this data. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described that indium and its compounds are irritants to skin (HSDB (Access on June 2016)), however, the source of this report is listed as List 2 and the original source of this information was not confirmed. Therefore, it was not adopted as the evidence of the classification. |
| 3 | Serious eye damage/eye irritation | Category 2A |
 Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
It is described that the soluble indium salts are very irritating to the eyes (ACGIH (7th, 2001)), therefore this substance was classified in Category 2A. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
There is no information related to carcinogenicity of the substance itself. Therefore, classification was not possible due to lack of data. Besides, as described in the same hazard class of the GHS classification of indium oxide (CAS RN 1312-43-2), as results of the classification by other organizations of related compounds, indium phosphide is classified in Group 2A by IARC (IARC 86 (2006)) and hardly soluble inorganic indium compounds are classified in Category 2A by the Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2015)). However, since this substance is a soluble compound, these classifications cannot be adopted. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No studies regarding a single exposure of humans to indium sulphate are reported. As for experimental animals, the LDLo value of oral administration for rabbits was 1,300 mg/kg and spastic paralysis, gastrointestinal tract necrotic changes, and interstitial nephritis occurred by gastrointestinal tract absorption (PATTY (6th, 2012)). It is reported that the LDLo value of oral administration for rats was 1,200 mg/kg and ulceration or bleeding of the stomach and necrosis of the gastrointestinal tract occurred (PATTY (6th, 2012)). However, information regarding doses is not enough to make a decision for classification. Besides, it is described in the Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), that Indium is irritating to the respiratory tract, but this information is from ICSC, so the original source cannot be confirmed. Also, it is not clear whether this description is regarding only metallic indium or indium compounds. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
No information regarding this substance is available. Besides, there is a report that indium chloride (III) (CAS RN 10025-82-8), which is also a soluble indium compound as well as this substance, caused decreased weight gain at 1,200 and 2,000 mg/kg/day in a 3-month repeated dose toxicity test using rats given by feeding (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)), however, there is no data regarding inhalation route. However, in a single exposure test (doses: 0.2, 2.0, 20 mg/m3) in which rats were exposed to an aerosol of indium (III) chloride for 1 hour, in proportion to the level of lung injury at 7th day after exposure, an restrictive lung lesion and increased airway sensitivity to acetylcholine were observed. Moreover, the lung collagen levels at 42 days after the exposure increased, depending on the exposure concentration. It is reported that these results indicate that exposure to indium (III) chloride is the cause of acute pulmonary inflammation (Japan Society For Occupational Health (JSOH) Recommendation of Occupational Exposure Limits Vol.49 (2007), Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). As for indium (III) nitrate (CAS RN 137770-61-1), which is also a soluble indium compound, it is reported that in a 20-week study (unknown frequency) on the oral route using rabbits, diffuse hepatocellular necrosis and changes in spleen weight and in blood occurred at 21,920 mg/kg (PATTY (6th, 2012)). However, the details are unknown, and there is no data by the inhalation route. As described above, there is no information on this substance and information on soluble indium compounds which is similar to this substance is insufficient. Therefore it was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |