GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 27176-87-0 |
| Chemical Name | Dodecylbenzenesulphonic acid |
| Substance ID | H28-B-14-METI, M-017B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2007 FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified |
- |
- | - | Due to a flash point data of 148.9 deg C (open-cup, ICSC (2002)), it is estimated that a flash point by the presbribed test method also corrresponds to "Not classified." |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | Because it is classified in Class 8 (corrosive substance), PG II and III (UN 2584 and 2586) in UNRTDG, it is estiamed that it does not correspond to pyrophoric substance which is hazard class with the highest precedence. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Due to the data that it is very soluble in water (ICSC (2002)), it is estimated that it does not react vigorously with water. |
| 13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen (S), but the classification is not possible due to no data. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, it is written in ICSC (2002) that it attacks metals and "collect leaking liquid in sealable non-metallic containers." |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Based on an LD50 value of 650 mg/kg (SIDS (2012)) for rats, this substance was classified in Category 4. Besides, this LD50 value is that of LAS C12 (linear alkylbenzene sulphonate) and is adopted in SIDS (2012) as the LD50 value for this substance. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, an LD50 value of 1,200 mg/kg (EPA RED (2006)) for rabbits has been reported. However, this was not adopted for classification since the target substance is unclear. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, an LC50 value for rats of 0.31 mg/L (EPA RED (2006)) has been reported. However, classification is not possible with this data alone since exposure time and target substance are unclear. Furthermore, since the LC50 value is higher than the saturated vapor pressure concentration (0.04 ng/L), a reference value as mist was applied. |
| 2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
It is described that LAS (linear alkylbenzene sulfonates) indicates mild to moderate primary irritation in humans (EHC 169 (1996)), and is irritating at concentrations not less than 20% (EHC 169 (1996), EPA RED (2006)). As for reports in experimental animals, there are reports that in a skin irritation test (EPA 870.2500) using rabbits, severe irritation was observed 72 hours after application (EPA RED (2006)), and that applying 0.5 g of 0, 20 and 30% LAS to the dorsal area of rats for 15 days resulted in erythema, edema and crusts in the 30% group (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). On the other hand, it is concluded in SIDS (2012) that, as for LAS being mainly composed of this substance, it is slightly irritating to both the skin and the eyes and recovery is quick even at high concentration (SIDS (2012). From the above, this substance was classified in Category 2 because there are several reports that it is irritating. |
| 3 | Serious eye damage/eye irritation | Category 1 |
 Danger |
H318 |
P305+P351+P338
P280 P310 |
It is reported that in an eye irritation test (EPA 870.2400) using rabbits, as a result of application of LAS (linear alkylbenzene sulfonic acid), corneal opacity was observed and was not reversed within 72 hours (EPA RED (2006)). In addition, in other eye irritation test using rabbits, as a result of applying 0.1mL of 0-5% LAS, severe symptoms including conjunctival edema, corneal opacity, hyperemia and so on were observed in the 5% solution group but resolved within 5 days. Therefore, it is described that LAS has a transient strong irritation but shows reversibility (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2012)). From the above, since severe symptoms were observed upon application at low concentrations, this substance was classified in Category 1. The information used in the previous classification was not adopted as evidence of classification because it is listed in List 3. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, as for LAS (linear alkylbenzene sulfonic acid), there are reports on a maximization test and Buehler test. It is reported that in maximization tests using guinea pigs, as a result of applying LAS (Lot A and Lot B), the rate of positive reaction was 65% in Lot A and not less than 45% in Lot B (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). In addition, there is a report that as a result of a Buehler test using guinea pigs, the percentage of positive reactions was 5% in Lot A and 0% in Lot B (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005). Moreover, it is reported that in a skin sensitization test in humans, sensitization with LAS is negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). The negative result in the OECD SIDS used in the previous classification could not be confirmed. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. As for in vivo, it is reported that in a mouse dominant lethal test, micronucleus tests using mouse bone marrow cells and chromosomal aberration tests using rat bone marrow cells are negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), EHC 169 (1996)). However, these results are for LAS (linear alkylbenzene sulfonic acid); and are not results focused on this substance. As for in vitro, bacterial reverse mutation tests and chromosomal aberration tests using cultured mammalian cells are negative (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), EHC 169 (1996)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
In a combined repeated dose toxicity study with a reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, no adverse effects on either parent animal or pups were observed (SIDS (2012)). However, it is difficult to classify this substance as "Not classified" based only on this result because this study is a screening test. No other data were available for classification. Therefore, the classification was not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There are no single exposure data for this substance in humans. As for animal studies, it is reported that in a single oral dose study using rats, at 1,580mg/kg, diarrhea, weakness and reduced voluntary activity prior to death were observed, but no significant gross abnormalities were seen at necropsy (SIDS (2012), SIDS Dossier (2012)). This substance was classified as "Classification not possible" since these symptoms alone are insufficient as classification evidence. Additionally, there is one reported case in which a woman who had ingested 160 ml of a 21% aqueous solution of LAS (linear alkylbenzene sulfonates: chain length unknown) with suicidal intent showed confusion, vomiting, pain in the pharyngeal and oral cavity and hypotension (EHC 169 (1996), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). In addition, in the previous classification, it was classified in Category 2 (respiratory organs) based on the description in ICSC(J) that this substance shows corrosivity to the respiratory tract. However, ICSC(J) is listed as a List 3 information source in the current GHS Classification Guidance for the Japanese Government, and no other information was obtained for the effects on the respiratory organs. Therefore, the classification result was changed. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There is no information in humans. As for experimental animals, in a combined repeated dose toxicity study with a reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, squamous cell hyperplasia of the stomach is observed at or above 200 mg/kg/day, which is equivalent to Category 2 (converted guidance value: 62 mg/kg/day (calculated based on the period of 28 days which is the shortest administration period in males)); and death (one case in males), soft feces, liquid feces and soiled perineal region, a decrease in body weight and food consumption, a decrease in activated partial thromboplastin time, an increase in A/G ratio and ALT, a decrease in albumin, a decrease in absolute weight of the salivary gland and heart, forestomach erosion/ulcers are observed at 400 mg/kg/day (converted guidance value: 124 mg/kg/day (calculated based on the period of 28 days which is the shortest administration period in males)), which is above Category 2 (SIDS (2012)). Since it is thought that the findings in the stomach are due to stimulation, they were not adopted as the rationale for classification. Therefore, this substance was classified as "Classification not possible." |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 48-hour EC50 = 3.4 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), it was classified in Category 2. Besides, a target water quality level to conserve aquatic organisms was set for linear alkyl benzenesulfonic acid and its salt (LAS) in 2013. The classification was conducted for this hazard class by adopting the data of dodecyl benzenesulfonic acid among the toxicity values which were indicated as the data available to set a target water quality level in the documents published by the Ministry of the Environment. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
 - |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified as "Not classified"due to 21-day NOEC (reproduction) = 3.3 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)) although rapid degradability data on dodecyl benzenesulfonic acid were not obtained. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because rapid degradability data on dodecyl benzenesulfonic acid were not obtained, and due to 96-hour LC50 = 4.5 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). It was classified in Category 2 by drawing a comparison between the above results. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |