GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 2837-89-0
Chemical Name 2-Chloro-1,1,1,2-tetrafluoroethane
Substance ID H28-B-10-METI, M-012B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives Not applicable
-
-
- -  Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Not classified
-
-
- -  Not combustible (HSDB (Access on October 2016)).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not classified
-
-
- -  It is classified in Division 2.2 (Non-toxic and non-flammable high-pressure gases) (UN 1021) in UNRTDG. However, because subsidiary risk 5.1 is not given, it was classified as "Not classified."
5 Gases under pressure Low pressure liquefied gas


Warning
H280 P410+P403  Due to Gas (GHS definition) and a critical temperature of 122.2 deg C (HSDB (Access on October 2016)), it corresponds to low-pressure liquefied gas.
6 Flammable liquids Not applicable
-
-
- -  Gas (GHS definition)
7 Flammable solids Not applicable
-
-
- -  Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  Gas (GHS definition)
9 Pyrophoric liquids Not applicable
-
-
- -  Gas (GHS definition)
10 Pyrophoric solids Not applicable
-
-
- -  Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable
-
-
- -  Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  Gas (GHS definition)
13 Oxidizing liquids Not applicable
-
-
- -  Gas (GHS definition)
14 Oxidizing solids Not applicable
-
-
- -  Gas (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Gas (GHS definition)
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to gas substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Not applicable
-
-
- -  Gas (GHS definition)
1 Acute toxicity (Dermal) Not applicable
-
-
- -  Gas (GHS definition)
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- -  Based on the reported 4-hour LC50 of 230,000 and 300,000 ppm (ca. 1,274,049-1,671,847 mg/m3) for rats (SIDS (2006), ECETOC JACC (2004), PATTY (6th, 2012)) , the substance was classified as "Not classified." Following the revision of the GHS classification guidance for the Japanese government, the category was revised.
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable
-
-
- -  Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  The substance was classified as "Classification not possible," because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government.
 As for in vivo, a micronucleus test in mice bone marrow cells was negative (SIDS (2006), PATTY (6th, 2012), ECETOC JACC (2004)), and as for in vitro, bacterial reverse mutation tests and in vitro mammalian cell chromosome aberration tests were both negative (SIDS (2006), PATTY (6th, 2012), ECETOC JACC (2004), EHC 139 (1992)).
6 Carcinogenicity Classification not possible
-
-
- -  In a carcinogenicity study in which rats were exposed by inhalation to the substance at concentrations up to 50,000 ppm (279,000 mg/m3) for 2 years, no increase in tumor incidence by the administration of the test substance was observed (SIDS (2006), ECETOC JACC (2004), PATTY (6th, 2012)).
 However, it is impossible to classify the substance as "Not classified" based on the negative results only in single species of experimental animals. Therefore, this substance could not be classified for this hazard class due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  In a developmental toxicity study by inhalation in pregnant rats (gestation days 6-15) and rabbits (gestation days 6-18) in the organogenesis period, no developmental toxicity was observed in the fetus of both species at up to the concentration of 50,000 ppm (279,000 mg/m3) where maternal toxicities (decreased weight gain and food consumption, and a reduced response to auditory stimuli in rats, decreased food consumption and decreased in-chamber activity in rabbits) were observed (ECETOC JACC (2004), SIDS (2006), PATTY (6th, 2012)).
 However, this substance could not be classified for this hazard class due to lack of data because there was no information on the effects on fertility and the sexual function.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501 		 No data were available for single exposure in humans.
 As for experimental animals, it is reported that in a single dose inhalation study for 4 hours in rats, depressed acoustic-startled responses, prostration, lethargy and incoordination were observed, but these anesthetic effects disappeared shortly after exposure (PATTY (6th, 2012), SIDS (2006), ECETOC JACC (2004), EHC 139 (1992)). Therefore, the substance was classified in Category 3 (narcotic effects).
 Besides, it is reported that a single inhalation exposure to this substance for 5 minutes at concentrations of 26,000 ppm or more which is above Category 2 to dogs, followed by intravenous administration of adrenaline 0.008 mg/kg and further exposure to this substance for 5 minutes, induced an increase in cardiac sensitivity to adrenaline (PATTY (6th, 2012), SIDS (2006), ECETOC JACC (2004), EHC 139 (1992)).
9 Specific target organ toxicity - Repeated exposure Not classified
-
-
- -  As for human, there is a report of liver injury in an epidemiological study on occupational exposure to the mixture of this substance and HCFC123, but it is reported that from the results of animal experiments, they were probably due to HCFC123 which has hepatotoxicity (SIDS (2006)).
 As for experimental animals, in several repeated dose toxicity studies by inhalation route (4 weeks, 90 days, and 24 months) using rats and mice, there were no reports of toxic effects which could be an evidence for GHS Classification and the NOAELs were as high as 5,000-50,000 ppm (SIDS (2006), ECETOC JACC (2004)).
 Therefore, this substance was classified as "Not classified."
10 Aspiration hazard Not applicable
-
-
- -  Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
12 Hazardous to the ozone layer Category 1


Warning
H420 P502  This substance is listed in Annexes to the Montreal Protocol.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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