GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 100-69-6 |
| Chemical Name | 2-Vinylpyridine |
| Substance ID | H28-B-04-METI, M-004B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 42 deg C (ICSC (2000)), it was classified in Category 3. Besides, stabilized one is classified in Division 6.1 (Poisonous Material), subsidiary risk 3 and 8, PG II (UN 3073) in UNRTDG. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, because stabilized one is classified in Division 6.1 (Poisonous Material), subsidiary risk 3 and 8, it is estimated that it does not correspond to self-reactive substances and mixtures which is hazard class with the highest precedence. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | Because stabilized one is classified in Division 6.1 (Poisonous Material), subsidiary risk 3 and 8, it is estimated that it does not correspond to pyrophoric liquids which is hazard class with the highest precedence. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 3 |
 Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
Based on a report that the LD50 value ranged between >50 and <300 mg/kg (OECD TG 423) for rats (SIDS (2014)), this substance was classified in Category 3. |
| 1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 |
P302+P352
P361+P364 P280 P312 P321 P405 P501 |
Based on the LD50 value of 640 mg/kg (SIDS (2014)) for rabbits, this substance was classified in Category 3. The classification was revised based on the new information. Besides, in the previous classification, an LD50 value of 160 mg/kg (PATTY (4th, 2000)) for guinea pigs was used as the rationale for classification. However, since an LD50 value for rabbits was obtained, which has a higher priority in the GHS Classification Guidance for the Japanese Government, it was classified using the LD50 value for rabbits. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 1 |
 Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There is a report that in a study using rabbits, as a result of the application of 0.5 ml of an undiluted solution of this substance for 1 hour, necrosis was observed (SIDS (2014)). In addition, it is described that this substance caused strong irritation to rabbits (PATTY (6th, 2012)). Moreover, there is a report that this substance caused skin burns after contact with human skin, and the site of inflammation became reddish-brown and took about a month to disappear (Initial Risk Assessment Report (NITE, CERI, NEDO,2005), PATTY (6th, 2012)). From the above, this substance was classified in Category 1. |
| 3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There is a report that in an eye irritation test using rabbits, strong irritation was observed (SIDS (2014), PATTY (6th, 2012)). In addition, there is a report that in an eye irritation test using guinea pigs, strong irritation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). Moreover, this substance is classified in Category 1 for skin corrosion/irritation. From the above, this substance was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Category 1 |
 Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is reported that exposure to this substance caused sensitization in humans, and there are several descriptions that this substance shows skin sensitization in humans (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)). Moreover, it is reported that in a skin sensitization test using guinea pigs, it is positive (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), PATTY (6th, 2012)). From the above, this substance was classified in Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
As for in vivo, in gene mutation tests (reporter gene: gpt and red/gam) using the liver, bone marrow, stomach (glandular stomach) and testes of transgenic mice (gpt delta) administered by oral, this substance is negative (JECDB (Access on October 2016)). As for in vitro, the results of bacterial reverse mutation tests were positive and negative, and a mammalian cell chromosome aberration test was positive (JECDB (Access on October 2016), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2014), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), PATTY (6th, 2012)). From the above, positive results are observed in vitro, but there was no positive report in in vivo tests. Therefore, this substance was classified as "Classification not possible" according to the GHS classification guidance for the Japanese Government. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described that in a test in which female mice were intraperitoneally administered with a total of 200 micro mol of this substance over 20 times at a rate of 3 times/week (equivalent to about 9 mg/kg/day), the incidence of lung adenoma/adenocarcinoma was 0/25, 0/23 and 24/24 in the vehicle control group, the group dosed with this substance, and the positive control group, respectively (SIDS (2014)). |
| 7 | Reproductive toxicity | Category 2 |
 Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In the reproduction/developmental toxicity screening test (OECD TG 421) using rats given by gavage, abnormal delivery cases including dystocia and stillborn, etc. were observed at 50 mg/kg/day or above. Also, of the twelve female parental animals in each group, at 50 mg/kg/day, two were euthanized; at 125 mg/kg/day, two were euthanized due to dystocia, three died before starting delivery, four died during the nursing period, and three were euthanized. As for male parental animals, an increase in the number of spermatogonia in stages I?VI, a decrease in the number of spermatogonia in stages IX?XI, and decreases in spermatocytes in the leptotene and pachytene or diplotene stage were observed at 125 mg/kg/day. As for the pups, all pups from 1 dam died at 50 mg/kg/day during the lactation period and all newborn pups died at 125 mg/kg/day (SIDS (2014), JECDB (Access on September 2016)). Besides, in female parental animals at 50 mg/kg/day or above and male parental animals at 125 mg/kg/day, macroscopic findings including mucosal hypertrophy in the forestomach, thymic atrophy and adrenal hypertrophy, and histopathological changes (ulcers, etc. in the forestomach, atrophy of the thymic cortex, hypertrophy of adrenal zona fasciculata cortical cells, etc.) are observed (JECDB (Access on September 2016)). From the above, since at the doses where effects on general toxicity were observed, abnormal delivery in the maternal animals and postnatal deaths were observed in the pups, this substance was classified in Category 2 for this hazard class. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
As for humans, there is a report that in several cases of brief exposure to this substance and 4-vinylpyridine during experiments, eye, nose, and throat irritations; headaches; nausea; nervousness; and anorexia were observed (PATTY (6th, 2012), SIDS (2014), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)). As for experimental animals, in a single oral dose study using rats, salivation, diarrhoea, vasodilation, reduced food intake, decrease in locomotor activity, muscle weakness and tremors were observed at 336 mg/kg, which is equivalent to Category 2 (SIDS (2014), Hazard Assessment Report (CERI, NITE, 2005). Moreover, there is a report that in a 17-day repeated dose toxicity study using rats administered by gavage, diminished activity, tremors and convulsions were observed at 500 mg/kg/day, which is equivalent to Category 2 (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), PATTY (6th, 2012)). It is thought that these symptoms are acute effects because all animals died after 1 - 2 doses. From the above, this substance was classified in Category 1 (nervous system) and Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There is no relevant information on humans. As for experimental animals, in a 28-day repeated dose toxicity study, a 92-day repeated dose toxicity study using rats administered by gavage, etc., effects on the stomach due to irritation (hyperplasia of squamous epithelium, submucosal edema, erosion and cellular infiltration in the forestomach, and submucosal edema, erosion, etc. in the glandular stomach) are observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), SIDS (2014)). In addition, it is reported that in a 92-day repeated dose toxicity study using rats administered by gavage, convulsions and salivation were observed at 180 mg/kg/day, which is above Category 2 (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), SIDS (2014), HSDB (Access on October 2016)). Moreover, it is reported that in a 17-day repeated dose toxicity study using rats administered by gavage, diminished activity, tremors and convulsions were observed at 500 mg/kg/day (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), PATTY (6th, 2012)). However, it is thought that these are acute effects because all animals died after 1 - 2 doses. From the above, within the range of Category 2, there are only effects on the stomach by oral administration due to irritation, so classification is not possible. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, from the numerical data (Viscosity: 1.17 mPa*s (20 deg C), density (specific gravity): 0.9985 (20/0 deg C)) listed in HSDB (Access on September 2016), the kinematic viscosity is calculated to be 1.17 mm2/sec (20 deg C). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 96-hour LC50 = 6.48 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001); Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005); SIDS, 2014; Initial Risk Assessment (NITE, CERI, NEDO, 2005)), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
 - |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991), and 21-day NOEC = 0.901 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001); Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005); SIDS, 2014; Initial Risk Assessment (NITE, CERI, NEDO, 2005)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because it is not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991), and 96-hour LC50 = 6.48 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001); Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005); SIDS, 2014; Initial Risk Assessment (NITE, CERI, NEDO, 2005)). It was classified in Category 2 from the above results. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |