GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 142-59-6
Chemical Name Disodium ethylenedicarbamodithioate [Nabam]
Substance ID H28-A-01-METI, M-016A
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- -  No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- -  No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  There is a metal (Na) present in the molecule, but it is estimated that it does not react vigorously with water due to water solubility data of > 200 g/L (20 deg C, GESTIS (Access on November 2016)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 Based on a reported LD50 value of 1,400 mg/kg for rats (Aquatreat DN-30 (containing approximately 30% nabam in aqueous solution)) (EPA RED (1996)), this substance was classified in Category 4 using a converted value of 420 mg/kg calculated as containing 100% of this substance.
 Besides, there is a report that the LD50 value for rats is 395 mg/kg (EHC 78 (1988), JMPR (1965)). This report, however, was not used for the classification because there is no description regarding the amount of the test substance contained.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Based on a reported LD50 value of >2,000 mg/kg for rabbits (Aquatreat DN-30 (containing approximately 30% nabam in aqueous solution)) (EPA RED (1996)), the converted value calculated as containing 100% of this substance is >600 mg/kg. However, a category cannot be identified from this value alone. Therefore, classification is not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, an LC50 value of > 2.19 mg/L for rats is reported (EPA RED (1996)), but there are no details regarding the amount, etc. of the test substance and it was not possible to identify the category from this value alone. Therefore, classification is not possible.
2 Skin corrosion/irritation Classification not possible
-
-
- -  There is information that the pure form of this substance causes irritation to the skin (HSDB (Access on November 2016)). Also, it is reported that as a result of applying this substance (19%) to the arm of 25 humans, 2 showed mild erythema and itching (EHC 78 (1988)). However, these data were judged as insufficient for use in the classification since the details are unknown.
 Besides, in a skin irritation test using rabbits, no irritation was observed by application of a solution containing 30% of this substance. Therefore, EPA RED classified this substance as Category IV (EPA RED (1996)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, in an eye irritation test using rabbits, no irritation was observed by application of a solution containing 30% of this substance. Therefore, EPA RED classified this substance as Category IV (EPA RED (1996)).
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
 It is described that, as a result of applying this substance (19%) to the arm of 25 humans, 2 persons showed mild erythema and itching and as a result of reapplication to the opposite arm after 14 days, 13 persons showed mild to strong erythema, edema and vesiculation, and from these findings, sensitization was suggested (EHC 78 (1988), EPA RED (1996)). From this information, EPA classified this substance as "Sensitizer" (EPA RED (1996)).
 Therefore, this substance was classified in Category 1.
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
 As for in vivo, a chromosomal aberration test using rat bone marrow cells was negative (EPA RED (1996)). As for in vitro, a bacterial reverse mutation test was negative, in vitro mammalian cell gene mutation tests were negative and positive, and sister chromatid exchange studies were positive (EPA RED (1996)). In the above-mentioned in vitro mammalian cell gene mutation tests, the results were negative when mouse S9 was used, but positive with rat S9. This effect may be attributable to ethylene thiourea, a metabolite of this substance (EPA RED (1996)).
 Therefore, this substance was classified in Category 2 based on the characteristics of the metabolite and the positive results in the presence of a metabolic activation system in the in vitro tests although there is no positive finding in vivo.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, it is described in a study using mice administered by gavage at 21.5 mg/kg/day from 7 days of age to weaning and thereafter given by the diet at 73 ppm up to 18 months of age, no significant increase in tumors was found (EHC 78 (1988), HSDB (Access on November 2016)).
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
 It is reported that in two developmental toxicity studies using rabbits orally dosed with a solution containing approximately 30% this substance (Aquatreat DN-30), increased incidences of fetal malformations such as hydrocephaly, domed cranium, and cleft palate, were observed at lower doses (8–10 mg/kg/day) than 100 mg/kg/day at which depressed body weight gain was seen in maternal animals (EPA RED (1996), HSDB (Access on November 2016)). Therefore, this substance was classified in Category 1B.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects)



Warning
H371
H335
H336
P308+P311
P260
P264
P270
P405
P501
P304+P340
P403+P233
P261
P271
P312
 As for humans, it is described that this substance is irritating to the skin and mucous membranes, and is a central nervous system depressant in high concentrations (HSDB (Access on November 2016)). Also, it is reported that multiple spraying workers exposed to high concentrations of this substance developed pharyngitis, rhinitis and bronchitis (HSDB (Access on November 2016)).
 As for experimental animals, although there is no description of animal species and administration route, it is reported that experimental animals acutely exposed to toxic doses of this substance exhibit first stimulation, then depression of central nervous system, bloody diarrhea, general weakness, and prostration, and that death was due to respiratory arrest (HSDB (Access on November 2016)). It is described that as the results of necropsy, severe irritation of the gastrointestinal tract and renal necrosis were seen in these animals, and that these effects may be due to carbon disulfide produced by decomposition of this substance in the acid environment of the stomach (HSDB (Access on November 2016)).
 Details were unknown regarding the effect on human skin. As for the effects on the gastrointestinal tract and kidney seen in experimental animals, there is no available information on the administration route and dose, even in the original source. Thus, these information were not adopted because it is difficult to determine a classification category.
 From the above, this substance was classified in Category 2 (central nervous system) and Category 3 (respiratory tract irritation, narcotic effects). Since HSDB is an information source in List 2, this substance was classified in Category 2 for the central nervous system.
9 Specific target organ toxicity - Repeated exposure Category 2 (thyroid)


Warning
H373 P260
P314
P501
 No information on humans is available.
 As for experimental animals, in a combined 90-day repeated dose toxicity study and neurotoxicity study using rats given a solution containing 31.1% this substance (Aquatreat DN-30) by gavage, a decrease in body weights and body-weight gains, a decrease in thyroxine, and an increase in absolute and relative thyroid weights were observed at 80 mg/kg/day (Nabam: 24.9 mg/kg/day) or more, which is equivalent to Category 2; and an increase in thyroid-stimulating hormone and mild hypertrophy of the follicular epithelium in the thyroid glands were observed at 260 mg/kg/day (Nabam: 80.86 mg/kg/day) (EPA RED (1996)).
 The findings in thyroid were considered to be due to direct effects on the thyroid since no effects on the liver were observed.
 Therefore, this substance was classified in Category 2 (thyroid).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From 48-hour LC50 = 0.44 mg/L for crustacea (Daphnia magna) (EHC 78, 1988), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 Reliable chronic toxicity data were not obtained. Because rapid degradability data were not obtained, and it was classified in Category 1 in acute toxicity, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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