GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 7439-98-7 |
| Chemical Name | Molybdenum |
| Substance ID | H27-B-077/C-126B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, there is the information that it is flammable in form of dust or powder (HSDB (Access on September 2015)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water from the observation result that it is insoluble in water (HSDB (Access on September 2015)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | It is an inorganic substance not containing oxygen or halogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic substance. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on a report that no change was observed after rats were exposed by inhalation to dust of this substance at 25-30 mg/L for 1 hour (converted 4-hour equivalent value: 6.25-7.50 mg/L) (ACGIH (7th, 2003)), it was classified as "Not classified." Since the test substance was solid, the reference values for dusts and mists were applied. |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Based on a description that it is irritating to human skin (HSDB (Access on September 2015)), it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Based on a description that it is irritating to human eyes (HSDB (Access on September 2015)), it was classified in Category 2. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | In a case-control study of workers working with molybdenum compounds for 21 years or more, as a result of an investigation on the relationship between lung cancer and molybdenum exposures, no relationship was found between lung cancer and the duration of exposure to chromium and mineral oils which were concurrently exposed, an exposure-response relationship was shown only in molybdenum exposure, and an increase in risk of lung cancer by molybdenum exposure was reported for the first time (ACGIH (7th, 2003)). As for experimental animals, in a carcinogenicity test where rats or mice were exposed to molybdenum trioxide which falls under soluble molybdenum compounds by inhalation for 2 years, increasing trend in incidence of alveolar/bronchiolar adenoma or carcinoma (combined) in male rats, increased incidences of alveolar/bronchiolar carcinoma and alveolar/bronchiolar adenoma or carcinoma (combined) in male mice, increased incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in female mice were observed, thus, NTP concluded on the weight of the evidence for carcinogenicity that there was equivocal evidence in male rats and some evidence in female and male mice (NTP TR 462 (1997)). The NTP test results about molybdenum trioxide were also described in ACGIH (7th, 2003) and PATTY (6th, 2012), however there is no test report on metallic molybdenum or insoluble molybdenum compounds. As for classification results of carcinogenicity by other organizations, only ACGIH classified soluble molybdenum compounds as "A3" (ACGIH (7th, 2003)), and metallic molybdenum and insoluble molybdenum compounds were not classified by any organization. From the above, this substance was classified as "Classification not possible" due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | There is no information on the reproductive toxicity of metallic molybdenum or insoluble molybdenum compounds. Therefore, classification was not possible due to lack of data. Besides, as for water soluble molybdenum compounds, as described in this hazard class of sodium molybdate (CAS RN: 7631-95-0), it was classified in Category 2 based on test data in experimental animals. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Based on a description that this substance is irritating to the respiratory tract (HSDB (Access on September 2015)), it was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. In humans, there is a report in balance studies wherein 24 girls (aged 7-9 years) were given molybdenum orally at an average dose of 75 mg/kg/day, low toxicity of molybdenum was verified, and an increased urinary concentration of molybdenum was the only change (ACGIH (7th, 2003)). On the other hand, there is a report which attributed gout and an increase in uric acid in a part of Armenia to the high level of molybdenum in soil (molybdenum intake was 10-15 mg/day) (ACGIH (7th, 2003), IRIS Summary (1992), Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012)). However, U.S. National Research Council concluded that these involvements were speculative and that molybdenum exposures could not be linked to bone disease or abnormalities of uric acid metabolism (ACGIH (7th, 2003)). As for occupational exposure, an increase in nonspecific symptoms (weakness, fatigue, headache, anorexia, joint and muscle pains) was reported among mining and metallurgy workers exposed to 60-600 mg/m3 molybdenum (ACGIH (7th, 2003)). On the other hand, in a study carried out in a molybdenum roasting plant exposed at a molybdenum concentration of 9.5 mg/m3, although the molybdenum concentrations in blood and urine, uric acid and ceruloplasmin were increased, no gout-like symptoms were observed (DFGOT vol. 18 (2002)). As for experimental animals, there is no data available. From the above, in humans, there are several reports, however, no case was obtained where molybdenum exposure and the effects were evident. Therefore, it was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |