GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 13494-80-9 |
| Chemical Name | Tellurium |
| Substance ID | H27-B-075/C-122B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | There is the information that it is combustible (ICSC (2000)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 340 deg C (ICSC (2000)). |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because there is the information that the experimental manufacturing method from tetradymite is done in water (Encyclopedia Chimica (Kyoritsu Shuppan Co., Ltd.) (1962)), it is estimated that it does not react vigorously with water. |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | It is an inorganic substance not containing oxygen or halogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic substance. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a report of an LD50 value of > 5,000 mg/kg (DFGOT Vol.22 (2006)) for rats, it was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report of an LC50 value (4 hours) of > 2.42 mg/m3 (DFGOT Vol.22 (2006)) for rats, however, it is not possible to specify a category with this value alone. Based on information from DFGOT Vol.22 (2006) with higher priority which was obtained in this survey, the text was revised. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no information on skin irritation among the information sources in List 1 or List 2. Since the information described in the previous classification was from the information source in List 3 and was not specific information, it was not adopted. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no information on eye irritation among the information sources in List 1 or List 2. Since information described in the previous classification was from the information source in List 3 and was not specific information, it was not adopted. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | For this substance and insoluble tellurium compounds, classification was not possible due to lack of data. Besides, for information on soluble tellurium compounds, please refer to this hazard class of tellurium tetrachloride (CAS RN: 10026-07-0). |
| 7 | Reproductive toxicity | Category 1B, Additional category: Effects on or via lactation |
 Danger |
H360 H362 |
P308+P313 P201 P202 P280 P405 P501 |
There is a report that increased incidence of hydrocephalus was observed in a test where metallic tellurium was administered by diet (165-220 mg/kg/day) to pregnant rats on organogenesis period (gestational day 6-15) (DFGOT vol. 22 (2006), PATTY (6th, 2012)), and a report that increased incidence of fetal encephalopathy was observed when metallic tellurium was administered by diet to pregnant rats during the gestation period (ACGIH (7th, 2001)), and there is a description that in a test where pregnant rats were dosed with tellurium dioxide by feeding during gestational days 15-19 (13-65 mg/kg/day), increased incidence of hydrocephalus, edema, exophthalmos was observed (DFGOT vol. 22 (2006)). Furthermore, there is a report that as a result of exposure to tellurium via breast milk until the postnatal day 0-28 in neonatal rats, Schwann cell and myelin degeneration in the sciatic nerves, and hypomyelination and myelin degeneration of the optic nerve in the central nervous system were observed (PATTY (6th, 2012)). From the above, since as a result of oral administration to pregnant animals, at doses where maternal toxicity is unknown, induction of external malformations such as hydrocephalus, and occurrence of encephalopathy were observed in fetuses, and myelination inhibition in the peripheral nerves and optic nerve were observed by exposure to this substance via breast milk in the neonatal period, multiple findings that oral exposure to this substance in the embryonic or neonatal period caused developmental disorders of the nervous system in the next generation were shown. Therefore, it was judged that the classification in Category 1B was appropriate for this hazard class, and "additional category for effects on or via lactation" was added. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
 Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract (HSDB (Access on September 2015)). For humans, in worker exposure cases (unknown route), anorexia, nausea, a metallic taste, garlic-like odor in the breath and sweat, drowsiness were reported (ACGIH (7th, 2001), DFGOT Vol.22 (2006)). Other than these symptoms, there is also a description of liver injury (HSDB (Access on September 2015)), however, the details were unknown. As for experimental animals, there are descriptions that prominent features of acute effects of this substance were pneumonia, hemolytic anemia, acute oral or non-oral tellurium intoxication resulting in restlessness, tremor, hyporeflexia, paralysis, convulsions, drowsiness, coma, and hematuria (ACGIH (7th, 2001), DFGOT Vol.22 (2006)), however, since the doses were unknown, it was not possible to decide a category. From the above, this substance is irritating to the respiratory tract, and has narcotic effects, it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, in the previous classification, it was classified in Category 2 (peripheral nervous system) based on a description in PATTY, but since this finding was not single exposure data, it was not adopted. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. In humans, in an occupational exposure case of exposure to tellurium fume (tellurium and tellurium oxide) at 0.01-0.1 mg/m3 for 22 months in a steel plant, garlic-like odor in the breath and sweat, dryness of the mouth, metallic taste, sleepiness were observed, and transient nausea was seen in workers close to the source of tellurium exposure (PATTY (6th, 2012), DFGOT Vol.22 (2006), ACGIH (7th, 2001)). As for experimental animals, in multiple tests with weanling rats dosed by feeding for 18 days to 6 months, effects on the nervous system (hindlimb paralysis caused by demyelination of the sciatic nerve, neural edema, Schwann cell degeneration, remyelination) were reported, and in a 30-day feeding tests with adult rats, garlic-like odor, blue-grey discolorations of the skin, restricted movement without signs of paralysis, death, and in the nerve fibers, myelin changes, segmental demyelination and remyelination were reported (DFGOT vol. 22 (2006)). These were seen in a range exceeding Category 2. Besides, there is a report that in a 13-15-week inhalation toxicity test with rats, at 10-100 mg/m3 (2 hours/day) (converted guidance value: 0.0033-0.033 mg/L) which was in a range of Category 1 or 2, decreased body weight, drowsiness, irritation of the respiratory tract, loss of fur, hemolysis (reduction in the number of erythrocytes and hemoglobin content, increase in bilirubin in the urine) etc. were observed, and half of the animals exposed at 100 mg/m3 died (other details were unknown) (DFGOT vol. 22 (2006)). However, since the original article was an abstract, and reliability could not be confirmed, it was not used for classification. From the above, no findings which should be adopted as the target organ were observed in humans. Effects on the nervous system were observed in experimental animals, however, the doses of these exceeded the range of Category 2. Therefore, it was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |