GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 139-65-1 |
| Chemical Name | 4,4'-Diamino diphenyl sulfide [4,4'-thiodianiline, thioaniline] |
| Substance ID | H27-B-057/C-093B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on the LD50 value for rats of 1,100 mg/kg (DFGOT Vol. 4 (1992), IARC 27 (1982)), it was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data. As for in vitro data, bacterial reverse mutation tests, and a chromosome aberration test and a sister chromatid exchange test with mammalian cultured cells were positive (IARC 27 (1982), DFGOT Vol. 4 (1992), NTP DB (Access on October 2015)). Although it was classified in Category 2 in the previous classification, the classification was changed because a positive finding from a DNA-damage test with mice (RTECS (2005)) which was described in the previous classification was not used. |
| 6 | Carcinogenicity | Category 2 |
 Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
There were no epidemiological studies that enable an evaluation of the relationship between human carcinogenicity and exposure specifically to this substance (NTP RoC (13th, 2014)). As for experimental animals, in carcinogenicity studies with rats or mice dosed by the oral route, in both sexes of both rats and mice, a significant increase in liver tumors (hepatocellular carcinoma or hepatocellular adenoma), in follicular epithelial-cell carcinomas of the thyroid or in the incidence of follicular-cell adenoma/carcinoma (combined) (female mice only), in addition, an increase in the incidence of benign and malignant tumors in the squamous epithelium of the external auditory canal (combined) in male rats, on the other hand, an increase in the incidence of adenocarcinomas of the uterus in female rats were observed, respectively (NTP TR 47 (1978), IARC Vol. 27 (1987), NTP RoC (13th, 2014)). As for carcinogenicity classifications by other organizations, IARC classified it in 2B (IARC Vol. 28 (1987)), Japan Society for Occupational Health (JSOH) in 2B (Recommendation of Occupational Exposure Limits (2014)), NTP as R (NTP RoC 13th ed. (2014)), and EU in Carc. 1B (ECHA CL Inventory (Access on September 2015)), respectively. Since there is no epidemiological information in humans, and the evidence for the EU classification is not known either, it was classified in Category 2 for this hazard class on the basis of the classification results by the organizations other than the EU. |
| 7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
There is no information on the reproductive effects of this substance in humans. As for experimental animals, it is described that after administration to pregnant rats by gavage (gestational day 1-5), as a result of confirmation of the presence or absence of implantation on the 10th day of gestation, a significant decrease in the number of implantations at 50 mg/kg/day, and complete inhibition of implantation at or above 100 mg/kg/day were observed (DFGOT Vol. 4 (1992)) [Note: there is also a similar description in IARC Vol. 27 (1982), but it was confirmed in the original paper (Kamboj V. P. and Kar A. B. (1966)) that rats were mistaken for mice as the species of test animals]. However, there is no other information available for the classification of this substance. Therefore, it was classified in Category 2 for this hazard class. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (thyroid, lung, liver) |
Warning |
H373 | P260 P314 P501 |
There is no information on the effects of repeated exposure in humans. As for experimental animals, in a carcinogenicity study where this substance was administered in the feed for 68-72 weeks to rats, as non-neoplastic lesions, follicular epithelial-cell hyperplasia of the thyroid at 1,500 ppm (approx. 75 mg/kg/day (converted by a classifier)), squamous metaplasia of the alveolar and bronchiolar epithelium, and hyperplasia of the hepatocytes and bile duct in the liver at doses of 1500 ppm or above were observed (NTP TR 47 (1978), IARC 27 (1982)). It is described that hyperplasia of the follicular epithelial cells of the thyroid was also observed in a 77-79 week dietary administration study with mice at or above 2,500 ppm (approx. 125 mg/kg/day (converted by a classifier)), which exceeds the range for Category 2, and that this effect was related to the administration of this substance (NTP TR 47 (1978)). Thus, the thyroid was also regarded as a target organ in addition to the lung and liver. Therefore, it was classified in Category 2 (thyroid, lung, liver) for this hazard class. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |