Item | Information |
---|---|
CAS RN | 624-83-9 |
Chemical Name | Methyl isocyanate |
Substance ID | H27-B-040/C-076B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -7 deg C (closed cup), and a boiling point of 39.5 deg C (HSDB (Access on July 2015)), it was classified in Category 2. Besides, it is classified in Division 6.1, Subsidiary Risk 3, PG I (UN 2480) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (cyanides) present in the molecule, but because it is classified in Division 6.1, Subsidiary Risk 3, PG I (UN 2480) in UNRTDG, it does not correspond to hazard class of the highest precedence, self-reactive substances and mixtures. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 534 deg C (HSDB (Access on July 2015)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to liquid with lower boiling point are not available. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
There are two reports of LD50 values for rats of 27-180 mg/kg (PATTY (6th, 2012)), 71 mg/kg (ACGIH (7th, 2001)). One corresponds to Category 3, and no category can be specified for the other one, therefore, it was classified in Category 3. |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
There are two reports of LD50 values of 0.12-0.41 mL/kg (115-394 mg/kg) (PATTY (6th, 2012)) and 0.22 mL/kg (211 mg/kg) (ACGIH (7th, 2001)) for rabbits. Since one of them corresponds to Category 3, and for the other one, a category cannot be specified, it was classified in Category 3. Since the unit of LD50, which was used as the evidence in the previous classification, was not mg/kg but mL/kg, this was corrected, and the category was revised. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on a reported LC50 value (6 hours) of 6.1 ppm (converted 4-hour equivalent value: 7.5 ppm) (PATTY (6th, 2012), ACGIH (7th, 2001)) for rats, it was classified in Category 1. Besides, the LC50 value is lower than the saturated vapor pressure concentration (457,895 ppm), therefore, a reference value in the unit of ppm was applied as vapour without mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There is a description that as a result of a 30-minute application of this substance to an auricle in a rabbit, erythema, edema, and necrosis were observed (HSDB (Access on August 2015)). In addition, there is a description that this substance is irritating to the skin in humans (PATTY (6th, 2012), HSDB (Access on August 2015)). From the above, it was classified in Category 2. Besides, this substance was classified in "Skin. Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There are descriptions that this substance causes irreversible damage to human eyes (ACGIH (7th, 2001), HSDB (Access on August 2015)), and that it is severely irritating to the eyes (HSDB (Access on August 2015)). In addition, there is a report that as a result of exposure to this substance (1.75-5 ppm) in volunteers, irritation of the eyes was observed (PATTY (6th, 2012)). From the above description of irreversible damage, it was classified in Category 1. Besides, this substance was classified in "Eye Dam. 1 H318" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
4 | Respiratory sensitization | Category 1 |
Danger |
H334 | P304+P340 P342+P311 P261 P284 P501 |
Because there are multiple descriptions that an exposure to this substance causes asthma (HSDB (Access on August 2015)), it was classified in Category 1. Besides, this substance was classified in "Resp. Sens. 1 H334" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There is a report that in an intracutaneous sensitization test with guinea pigs, immunological response was observed in all the test animals (16) (ACGIH (2001)), and there is a description that the skin sensitization was also caused in humans (HSDB (Access on August 2015)), therefore, it was classified in Category 1. Besides, this substance was classified in "Skin sens. 1 H317" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
As for in vivo, in the human epidemiological case, there is a report that the incidence of chromosomal aberrations in peripheral blood lymphocytes of two persons exposed to the gas of this substance was high (HSDB 2005). In micronucleus tests of peripheral blood erythrocytes of male and female mice exposed by inhalation, negative results (NTP DB (Access on August 2015)) and a weak but significant increase of micronuclei only at high doses (NTP DB (Access on August 2015)) were observed. As for in vitro, it was negative in a bacterial reverse mutation test, and positive in a mouse lymphoma test, a chromosomal aberrations test, and a sister chromatid exchange test with mammalian cultured cells (ACGIH (7th, 2001), NTP DB (Access on August 2015), PATTY (6th, 2012)). From the above, because there are positive results of in vivo somatic cell mutagenicity, it was classified in Category 2. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In 2-year carcinogenicity tests on this substance by the inhalation route in rats or mice, a slight increase in the incidence of pheochromocytoma in the adrenal medulla and adenomas of pancreatic acinar cells only in male rats were observed, and no increase in the incidence of tumors in female rats or male and female mice was seen (HSDB (Access on August 2015)). Based on the fact that there is no available information on humans, and the results in experimental animals described above, US EPA classified it in Group D (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015)), but there is no classification result by other organizations. From the above, it was classified as "Classification not possible" for this hazard class. |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
As a result of an investigation after interviewing pregnant women who had been neighborhood inhabitants to the factory in India and were possibly exposed to this substance in an accident at the factory, increases in the number of stillbirths, spontaneous abortions, and increased neonatal mortality after birth were reported (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015), HSDB (Access on August 2015)). Also for experimental animals, there is a description that in tests in which pregnant mice were given single inhalation exposure (day 8 of pregnancy) or 4-day inhalation exposure (days 14-17 of pregnancy), fetal toxicity such as low value of body weight or a slight increase in mortality in fetuses was observed with or without maternal toxicity (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015), HSDB (Access on August 2015)). From the above, the case of epidemiological investigation is only the one from the accident, but the result is considered to be supported by animal tests to some extent, therefore, it was classified in Category 1B for this hazard class. Besides, this substance was classified in Repr. 2 in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
It is reported that inhalation exposure to this substance caused respiratory tract irritation, chest pain, coughing, labored breathing, vomiting, dyspnea and pulmonary edema, and oral exposure caused abdominal pain in humans (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on August 2015)). As for experimental animals, there are reports that inhalation exposure at 6.1 ppm (0.014 mg/L) (a dose corresponding to Category 1) caused lacrimation, hypoactivity, dyspnea, and oral respiration in rats, and the symptoms were mitigated within 2 weeks after exposure (ACGIH (7th, 2001), PATTY (6th, 2012)). From the above, because this substance causes respiratory tract irritation and effects on the respiratory organs, it was classified in Category 1 (respiratory organs). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |