GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 624-83-9
Chemical Name Methyl isocyanate
Substance ID H27-B-040/C-076B_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
Based on a flash point of -7 deg C (closed cup), and a boiling point of 39.5 deg C (HSDB (Access on July 2015)), it was classified in Category 2.
Besides, it is classified in Division 6.1, Subsidiary Risk 3, PG I (UN 2480) in UNRTDG.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with self-reactive properties (cyanides) present in the molecule, but because it is classified in Division 6.1, Subsidiary Risk 3, PG I (UN 2480) in UNRTDG, it does not correspond to hazard class of the highest precedence, self-reactive substances and mixtures.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 534 deg C (HSDB (Access on July 2015)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to liquid with lower boiling point are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501
There are two reports of LD50 values for rats of 27-180 mg/kg (PATTY (6th, 2012)), 71 mg/kg (ACGIH (7th, 2001)). One corresponds to Category 3, and no category can be specified for the other one, therefore, it was classified in Category 3.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
There are two reports of LD50 values of 0.12-0.41 mL/kg (115-394 mg/kg) (PATTY (6th, 2012)) and 0.22 mL/kg (211 mg/kg) (ACGIH (7th, 2001)) for rabbits. Since one of them corresponds to Category 3, and for the other one, a category cannot be specified, it was classified in Category 3. Since the unit of LD50, which was used as the evidence in the previous classification, was not mg/kg but mL/kg, this was corrected, and the category was revised.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 1


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on a reported LC50 value (6 hours) of 6.1 ppm (converted 4-hour equivalent value: 7.5 ppm) (PATTY (6th, 2012), ACGIH (7th, 2001)) for rats, it was classified in Category 1. Besides, the LC50 value is lower than the saturated vapor pressure concentration (457,895 ppm), therefore, a reference value in the unit of ppm was applied as vapour without mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
There is a description that as a result of a 30-minute application of this substance to an auricle in a rabbit, erythema, edema, and necrosis were observed (HSDB (Access on August 2015)). In addition, there is a description that this substance is irritating to the skin in humans (PATTY (6th, 2012), HSDB (Access on August 2015)). From the above, it was classified in Category 2. Besides, this substance was classified in "Skin. Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There are descriptions that this substance causes irreversible damage to human eyes (ACGIH (7th, 2001), HSDB (Access on August 2015)), and that it is severely irritating to the eyes (HSDB (Access on August 2015)). In addition, there is a report that as a result of exposure to this substance (1.75-5 ppm) in volunteers, irritation of the eyes was observed (PATTY (6th, 2012)). From the above description of irreversible damage, it was classified in Category 1. Besides, this substance was classified in "Eye Dam. 1 H318" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501
Because there are multiple descriptions that an exposure to this substance causes asthma (HSDB (Access on August 2015)), it was classified in Category 1. Besides, this substance was classified in "Resp. Sens. 1 H334" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
There is a report that in an intracutaneous sensitization test with guinea pigs, immunological response was observed in all the test animals (16) (ACGIH (2001)), and there is a description that the skin sensitization was also caused in humans (HSDB (Access on August 2015)), therefore, it was classified in Category 1. Besides, this substance was classified in "Skin sens. 1 H317" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
As for in vivo, in the human epidemiological case, there is a report that the incidence of chromosomal aberrations in peripheral blood lymphocytes of two persons exposed to the gas of this substance was high (HSDB 2005). In micronucleus tests of peripheral blood erythrocytes of male and female mice exposed by inhalation, negative results (NTP DB (Access on August 2015)) and a weak but significant increase of micronuclei only at high doses (NTP DB (Access on August 2015)) were observed. As for in vitro, it was negative in a bacterial reverse mutation test, and positive in a mouse lymphoma test, a chromosomal aberrations test, and a sister chromatid exchange test with mammalian cultured cells (ACGIH (7th, 2001), NTP DB (Access on August 2015), PATTY (6th, 2012)). From the above, because there are positive results of in vivo somatic cell mutagenicity, it was classified in Category 2.
6 Carcinogenicity Classification not possible
-
-
- - In 2-year carcinogenicity tests on this substance by the inhalation route in rats or mice, a slight increase in the incidence of pheochromocytoma in the adrenal medulla and adenomas of pancreatic acinar cells only in male rats were observed, and no increase in the incidence of tumors in female rats or male and female mice was seen (HSDB (Access on August 2015)). Based on the fact that there is no available information on humans, and the results in experimental animals described above, US EPA classified it in Group D (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015)), but there is no classification result by other organizations. From the above, it was classified as "Classification not possible" for this hazard class.
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
As a result of an investigation after interviewing pregnant women who had been neighborhood inhabitants to the factory in India and were possibly exposed to this substance in an accident at the factory, increases in the number of stillbirths, spontaneous abortions, and increased neonatal mortality after birth were reported (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015), HSDB (Access on August 2015)). Also for experimental animals, there is a description that in tests in which pregnant mice were given single inhalation exposure (day 8 of pregnancy) or 4-day inhalation exposure (days 14-17 of pregnancy), fetal toxicity such as low value of body weight or a slight increase in mortality in fetuses was observed with or without maternal toxicity (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015), HSDB (Access on August 2015)). From the above, the case of epidemiological investigation is only the one from the accident, but the result is considered to be supported by animal tests to some extent, therefore, it was classified in Category 1B for this hazard class.
Besides, this substance was classified in Repr. 2 in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
It is reported that inhalation exposure to this substance caused respiratory tract irritation, chest pain, coughing, labored breathing, vomiting, dyspnea and pulmonary edema, and oral exposure caused abdominal pain in humans (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on August 2015)).
As for experimental animals, there are reports that inhalation exposure at 6.1 ppm (0.014 mg/L) (a dose corresponding to Category 1) caused lacrimation, hypoactivity, dyspnea, and oral respiration in rats, and the symptoms were mitigated within 2 weeks after exposure (ACGIH (7th, 2001), PATTY (6th, 2012)).
From the above, because this substance causes respiratory tract irritation and effects on the respiratory organs, it was classified in Category 1 (respiratory organs).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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