GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 822-36-6 |
| Chemical Name | 4-Methylimidazole |
| Substance ID | H27-A-032/C-062A_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 555 degrees C (HSDB (Access on July 2015)). |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | It is an organic compound that does not contain oxygen, fluorine, or chlorine. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 3 |
 Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
From an LD50 value of 173 mg/kg for rats (NTP TR535 (2007)), it was classified in Category 3. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
It is reported that burns in the skin were observed in a Draize test using rabbits, but there is no description of recovery (HSDB (Access on July 2015)). Besides, it is written that this substance is irritating to the skin (HSDB (Access on July 2015)). The substance was classified in Category 2 from the above results. |
| 3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It is reported that eye irritation was observed in a Draize test using rabbits, but there is no description of recovery (HSDB (Access on July 2015)). Besides, it is written that this substance is irritating to the eyes (HSDB (Access on July 2015)). The substance was classified in Category 2 from the above results. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible."As for in vivo, a micronucleus test using bone marrow cells of rats and mice in intraperitoneal administration, and a micronucleus test using mouse peripheral erythrocytes in diet administration were all negative (IARC 101 (2012), NTP TOX067 (2004)). As for in vitro, a bacterial reverse mutation test was negative (IARC 101 (2012), NTP TOX067 (2004)). |
| 6 | Carcinogenicity | Category 2 |
 Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
There is no carcinogenicity information in humans. As for experimental animals, in a 2-year carcinogenicity test using rats and mice in an oral route (in the diet), increased incidences of the following were observed (NTP TR535 (2007), IARC 101 (2012)): alveolar/bronchiolar adenoma at 312 ppm (about 40 mg/kg/day) or higher in female mice and alveolar/bronchiolar adenoma and carcinoma (combined) at 625 ppm (about 80 mg/kg/day) or higher in female mice; and alveolar/bronchiolar carcinoma and alveolar/bronchiolar adenoma and carcinoma (combined) at 1,250 ppm (about 170 mg/kg/day) in male mice and mononuclear cell leukemia at 5,000 ppm (about 260 mg/kg/day) in female rats. From the above results, IARC considered that there is sufficient evidence of carcinogenicity in experimental animals, and classified it in Group 2B (IARC 101 (2012)). There is no classification result by other organizations. Therefore, the substance was classified in "Category 2" for this hazard class in accordance with the GHS classification guidance for the Japanese government. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | As a result of 14-week diet administration of this substance in rats, dose-dependent degeneration of seminiferous tubules, atrophy of prostate, and decreased epididymal sperm motility were observed in males. NTP concluded that this substance is a reproductive toxic substance ("Reprotoxicant" described in the original text) in male rats based on dose-dependent testicular degeneration (NTP TR535 (2007)). Moreover, after subcutaneous injection of 50 to 100 mg/kg this substance in male rats, LH secretion decreased, and 2 hours after administration, decreased testosterone concentrations in serum and testicular interstitial fluid and decreased testicular interstitial fluid formation were observed. Therefore, this substance reduces male fertility by suppressing testosterone production and testicular interstitial fluid formation. Furthermore, it is written that mechanism via disrupting pituitary LH secretion by this substance is suggested for the mechanism of above actions (NTP TR535 (2007)). From the above, this substance shows testicular toxicity in male rats "at doses above Category 2 in specific target organ toxicity (repeated exposure)." However, due to no report of a test in mating with unexposed or exposed females and unknown effects on fertility, the classification is not possible due to lack of data. Besides, NTP announced that a continuous breeding test using rats was conducted and completed to investigate fertility in male and female rats (NTP Testing status (Access on July 2015)), but data have not been published as of September 2015. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
From the information that inhaling this substance gives severe damage to the tissue of respiratory tract and mucous membranes (HSDB (Access on July 2015)), it was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
Warning |
H373 | P260 P314 P501 |
There is no human information. As for experimental animals, in a 2-year diet administration toxicity test (in the diet) using rats, histiocytosis, chronic inflammations, and focal fatty change of hepatocytes in the liver were observed at 1,250 ppm (males: 55 mg/kg/day, females: 60 mg/kg/day) within a range of Category 2 (NTP TR535 (2007)). Therefore, it was classified in Category 2 (liver). Besides, in a 14-week diet administration toxicity test (in the diet) using rats, effects on blood system, nervous system, liver, testis, and prostate were observed (NTP TOX067 (2004)). Moreover, in a 2-year repeated oral administration toxicity test (in the diet) using mice, effects on lung (alveolar epithelial hyperplasia) were found (NTP TR535 (2007)). However, these were in a range that is above Category 2. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data were not obtained. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |