Item | Information |
---|---|
CAS RN | 91-57-6 |
Chemical Name | 2-Methylnaphthalene |
Substance ID | H27-B-025/C-046B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2008 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
7 | Flammable solids | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 488 degrees C (GESTIS (Access on June 2015)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Not applicable |
- |
- | - | It is an organic compound that does not contain oxygen, fluorine, or chlorine. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Although it is a solid with a melting point of 55 degrees C or lower, the classification is not possible because of no data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Four LD50 values of 1,630 mg/kg (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), 4,310 mg/kg (males), 3,270 mg/kg (females) (IRIS Tox. Review (2003)), and 4,050 mg/kg (SIDS (2011)) were reported for rats. Because one corresponds to Category 4, and three correspond to "Not classified" (Category 5 in UN GHS classification), it was classified as "Not classified" (Category 5 in UN GHS classification) to which most of the data correspond. By adding data from Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012), SIDS (2011), the Category was revised. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | From a reported LD50 value (OECD TG 402) of > 2,000 mg/kg for rats (SIDS (2011)), and reported LD50 values of 6,130 mg/kg (males) and 4,790 mg/kg (females) for rabbits (IRIS Tox. Review (2003)), it was classified as "Not classified." By adding the data from SIDS (2011) and IRIS Tox. Review (2003), the Category was revised. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Solids" according to GHS definition. Besides, it is reported that toxicity effects were not observed after rats were exposed to the saturated vapour of a 2:1 mixture of this substance and 1-methylnaphthalene for 6 hours (IRIS Tox. Review (2003)). |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is reported that in a test using rabbits in 4-hour or 24-hour occlusive application of this substance, a 4-hour application group showed reversible weak redness and edema, and a 24-hour application group showed moderate to severe irritation (BUA 47 (1990)). Moreover, it is written that after application of a mixture of this substance and 1-methylnaphthalene to rabbit skin, it was irritating but not corrosive (IRIS Tox. Review (2003)). Besides, it is not specific information, but it is written that this substance is irritating to the skin without mentioning the extent of irritation (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)). From the above, from the result that slight irritation was observed after 4-hour application, it was classified as "Not classified" (Category 3 in UN GHS classification). |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
From the information that this substance is irritating to eyes (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)), it was classified in Category 2. Besides, it is written that it was irritating but not corrosive after application of a mixture of this substance and 1-methylnaphthalene to rabbit eyes (IRIS Tox. Review (2003)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that in a maximization test (OECD TG406, GLP compliance) using a commonly distributed product containing this substance (this substance 60%, 1-methylnaphthalene 40%), it was not sensitizing (BUA 240 (2005)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. There are no in vivo data. As for in vitro, there are results of negative in a bacterial reverse mutation test and a chromosomal aberration test in cultured mammalian cells, and positive in a sister chromatid exchange test, but this substance was assessed to be not mutagenic in vitro (SIDS (2011); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ACGIH (7th, 2007); IRIS Tox. Review (2003); ATSDR (2005); NTP DB (Access on August 2015)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In an 81-week diet administration test in mice, a statistically significant increase in an incidence of lung adenoma was observed in males of a low dose group, but it was not a dose-dependent change (ACGIH (7th, 2007), ATSDR (2005)). As the classification results in carcinogenicity by other organizations, EPA classified in "I (Inadequate to assess human carcinogenic potential)" in 1991 (IRIS Summary (Access on August 2015)), and ACGIH classified this substance and its isomer, 1-methylnaphthalene in "A4" in 2006 (ACGIH (7th, 2007)). From the above, this substance was classified as "Classification not possible" in this hazard class in accordance with the GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that in an 81-week diet administration test in mice, effects were not observed in reproductive organs of males and females up to the dose corresponding to 113.8 mg/kg/day (ATSDR (2005)). |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on June 2015)). As for experimental animals, it is reported that the concentration that depressed the respiratory rate by 50% (RD50) was 67 mg/m3 (0.067 mg/L) in inhalation exposure in mice, and a change in respiration occurred, resulting from irritation (ACGIH (7th, 2007); SIDS (2011); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). It is reported that decreased sensitivity to pain was assumed because a reaction time of licking paws to a heat stimulus increased in rats in inhalation exposure (0.35-0.53 mg/L) (ATSDR (2005), SIDS (2011), IRIS Tox. Review (2003), BUA 240 (2005)). This decreased sensitivity to pain was judged to be narcotic effects. From the above, the substance was classified in Category 3 (respiratory tract irritation, narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (lung) |
Warning |
H373 | P260 P314 P501 |
As for experimental animals, in an 81-week diet administration toxicity test using mice, pulmonary alveolar proteinosis was observed at the doses of 54.3 mg/kg/day for males and 50.3 mg/kg/day for females. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) These doses were within a range of Category 2. Therefore, it was classified in Category 2 (lung). Besides, in a test in which mice were dermally administered a mixture of 1-methylnaphthalene and 2-methylnaphthalene twice a week for 30 weeks (total dose amount: 119 mg/kg) or 61 weeks (total dose amount: 30, 119 mg/kg), alveolar proteinosis was found in both at 119 mg/kg, and dead animals showed endogenous lipid pneumonia (lipoid pneumonia) which are thought to be a cause of death. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 48-hour EC50 = 1.39 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BioWin), and 21-day NOEC (reproduction) = 0.233 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable, and for 96-hour LC50 = 1.456 mg/L fish (Oncorhynchus mykiss) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). From the above results, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |