GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 90-12-0 |
| Chemical Name | 1-Methylnaphthalene |
| Substance ID | H27-B-024/C-045B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P403+P235 P210 P280 P501 |
Based on a flash point of 82 degrees C (HSDB (Access on June 2015)), it was classified in Category 4. |
| 7 | Flammable solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 529 degrees C (HSDB (Access on June 2015)) |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | It is an organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From a reported LD50 value of 1,840 mg/kg for rats (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012), HSDB (Access on June 2015)), it was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | From a reported LDLo value of 7,500 mg/kg for rabbits (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), it was classified as "Not classified." Based on the newly obtained data of "Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)," the category was revised. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that toxicity effects were not observed after rats were exposed to the saturated vapour of a 2:1 mixture of 2-methylnaphthalene and this substance for 6 hours (IRIS Tox. Review (2003)). |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is reported that in a test using rabbits in 4-hour or 24-hour occlusive application of this substance, a 4-hour application group showed reversible weak redness and edema, and a 24-hour application group showed moderate to severe irritation (BUA 47 (1990)). Moreover, it is written that after application of a mixture of this substance and 2-methylnaphthalene to rabbit skin, it was irritating but not corrosive (IRIS Tox. Review (2003)). Besides, it is not specific information, but it is written that this substance is irritating to the skin without mentioning the extent of irritation (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)). From the above, from the result that slight irritation was observed after 4-hour application, it was classified as "Not classified" (Category 3 in UN GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
From the information that this substance is irritating to eyes (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on July 2015)), it was classified in Category 2. Besides, it is written that it was irritating but not corrosive after application of a mixture of this substance and 2-methylnaphthalene to rabbit eyes (IRIS Tox. Review (2003)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that in a maximization test (OECD TG406, GLP compliance) using a commonly distributed product containing this substance (this substance 40%, 2-methylnaphthalene 60%), it was not sensitizing (BUA 240 (2005)). |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. There are no in vivo data, and as for in vitro, a bacterial reverse mutation test, a chromosomal aberration test and a sister chromatid exchange test in human lymphocytes were all negative. (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ACGIH (7th, 2007); ATSDR (2005); NTP DB (Access on August 2015)) |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | In an 81-week diet administration test in mice, an increased incidence of bronchiolar/alveolar adenoma or adenocarcinoma was observed in males, but not in females. (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); ATSDR (2005)) As the classification results in carcinogenicity by other organizations, only ACGIH classified carcinogenicity of this substance and its isomer, 2-methylnaphthalene as A4 (ACGIH (7th, 2007)). From the above, this substance was classified as "Classification not possible" in this hazard class. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test in rats in gavage administration (OECD TG 422), increased liver weight was observed in both males and females at the highest dose of 250 mg/kg/day, but toxicity effects were not found in sexual function and fertility of parent animals and development of offspring by day 4 after birth. (Safety test results by Ministry of Economy, Trade and Industry (Access on August 2015)) However, it is not judged as "Not classified" only from this data which are screening test results. Beside this, it is reported that in a 81-week diet administration test in mice, effects were not observed in reproductive organs of males and females up to the dose corresponding to 143.7 mg/kg/day (ATSDR (2005); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)). From the above, the substance was classified as "Classification not possible" due to lack of data in this hazard class. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012); HSDB (Access on June 2015)). As for experimental animals, it is reported that the concentration that depressed the respiratory rate by 50% (RD50) was 129 mg/m3 (0.129 mg/L) in inhalation exposure in mice (ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)), which was judged to be a change in respiration by irritation. It is reported that decreased sensitivity to pain was assumed because a reaction time of licking paws to a heat stimulus increased in rats in inhalation exposure (0.25-0.41 mg/L) (ATSDR (2005), BUA 240 (2005)). This decreased sensitivity to pain was judged to be narcotic effects. From the above, the substance was classified in Category 3 (respiratory tract irritation, narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (lung) |
 Warning |
H373 | P260 P314 P501 |
As for experimental animals, in an 81-week oral administration toxicity test using mice, pulmonary alveolar proteinosis was observed at the doses of 71.6 mg/kg/day for males and 75.1 mg/kg/day for females. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) These doses were within a range of Category 2. Therefore, it was classified in Category 2 (lung). Besides, in a test in which mice were dermally administered a mixture of 1-methylnaphthalene and 2-methylnaphthalene twice a week for 30 weeks (total dose amount: 119 mg/kg) or 61 weeks (total dose amount: 30, 119 mg/kg), alveolar proteinosis was found in both at 119 mg/kg, and dead animals showed endogenous lipid pneumonia (lipoid pneumonia) which are thought to be a cause of death. (ATSDR (2005); ACGIH (7th, 2007); Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan (2012)) |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 48-hour LC50 = 1.42 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
 - |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being rapidly degradable (hardly degradable, a degradation rate by 28-day BOD = 2%, a degradation rate by HPLC = 0% (Official Bulletin of Economy, Trade and Industry, 2005)), 21-day NOEC (reproduction) = 0.223 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being rapidly degradable, and 96-hour LC50 = 5.66 mg/L for fish (Oryzias latipes) (Result of the initial environmental risk assessment of chemicals, Vol. 10, Ministry of the Environment in Japan, 2012). From the above results, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |