Item | Information |
---|---|
CAS RN | 7783-96-2 |
Chemical Name | Silver (I) iodide |
Substance ID | H27-B-020/C-041B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
7 | Flammable solids | Not classified |
- |
- | - | It is non-flammable (GESTIS (Access on June 2015)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is non-flammable (GESTIS (Access on June 2015)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is non-flammable (GESTIS (Access on June 2015)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water from water solubility data measured. Water solubility: 28E-07 g/L (25 degrees C) (HSDB (Access on June 2015)). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound that does not contain oxygen but contains halogen (I), but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, Japan Society for Occupational Health classified iodine and its compounds as a skin sensitizer Group 2, but it is written that not all compounds were identified (The Recommendation of Acceptable Concentration of the Japan Society for Occupational Health (2014)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, the HSDB information described in the previous classification could not be confirmed. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There is no carcinogenicity information on this substance itself. However, as mentioned in specific target organ toxicity (repeated exposure), this substance is absorbed in an inhalation route, and it is thought that its toxicity reflects that of iodine, iodide, and silver compounds. As the classification result for carcinogenicity by other organizations, ACGIH classified iodine and iodide in A4 (ACGIH (7th, 2008)), but the classification in carcinogenicity was not given to silver and its compounds (ACGIH (2015)). Therefore, based on the ACGIH's classification result on iodine and iodide, this substance was classified as "Classification not possible" in this hazard class. |
7 | Reproductive toxicity | Category 1B, Additional category: Effects on or via lactation |
Danger |
H360 H362 |
P308+P313 P201 P202 P280 P405 P501 |
There is no reproductive toxicity information on this substance itself. However, as mentioned in specific target organ toxicity (repeated exposure), this substance is absorbed in an inhalation route, and it is thought that its toxicity reflects that of iodine, iodide, and silver compounds. As the classification of iodide in this hazard class, potassium iodide (CAS number: 7681-11-0) was classified in Category 1B, Additional Category: Effects on or via lactation. However, the rationale data for this classification were based on the information in an oral route in humans as a whole. In the report of Willard, D.H. and Bar, W.J. (1961), the fact was just shown that in gavage administration of Na131I and Ag131I to one sheep each, 131I uptake amount into thyroid was similar (a maximum uptake rate of 131I against dosed amount into thyroid tissue: 56% (after 28 hours) and 48% (after 34 hours) for NaI and AgI respectively), but an absorption experiment of oral dosing Ag131I was not conducted in mice. Therefore, it could not be said that absorption rate of silver iodide in an oral route is as well as that of soluble iodide. However, because it is thought that this substance will be absorbed after inhalation and cause toxicity corresponding to oral administration of potassium iodide as iodide in blood, it was judged that the classification for potassium iodide is applicable to this substance as well. Accordingly, it was classified in Category 1B in this hazard class, and effects on or via lactation were added. Besides, there is the information on reproductive effects of silver compounds that direct injection of silver nitrate into the uterus of pregnant monkeys caused abortion, or silver was detected in the brain of newborns after intraperitoneal injection of silver lactate in pregnant rats (ATSDR (1990), ACGIH (7th, 2001)). However, there is no information available for classification in this hazard class. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | It is written that there were incident cases of multiple people in high-level exposure to this substance, in which pathological symptom was not observed (HSDB (Access on June 2015)), but there is no detailed information. The classification is not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (skin, thyroid, respiratory organs, systemic toxicity) |
Danger |
H372 | P260 P264 P270 P314 P501 |
As the only information on this substance, it is reported that workers in the operation of artificial rainfall using this substance showed the coloring of hands but no health effects (HSDB (Access on June 2015)). However, the information on absorption of this substance in an inhalation route is written in ATSDR (2004) and CICAD 72 (2009), and the original literature (Willard, D.H. and Bar, W.J.: Acta Radiologica, 55, 486-496 (1961)) was obtained and investigated in details. As a result, in a disposition test in mice in inhalation exposure to 131I-silver iodide particles (Ag131I), it is shown that a total deposition rate of this insoluble substance was as low as about 12% which was about 1/5 in comparison with 131I2 (iodine) vapour, similarly exposed, but this substance was distributed in the whole body (multiple organs) after rapid absorption, and a distribution rate and time course of change per organ such as thyroid did not make much difference from one another in comparison based on total body burden (Willard, D.H. and Bar, W.J. (1961)). Therefore, it is conceivable that this substance is also absorbed in an inhalation route, and its toxicity reflects that of iodine, iodide, and silver compounds. As for silver compounds, it is written that long-term exposure causes argyria (PATTY (6th, 2012), ACGIH (7th, 2008), HSDB (Access on June 2015)). However, it is conceivable that it does not suggest serious health effects in humans. As for humans, for iodine and iodide, iodine causes hypothyroidism or hyperthyroidism (ACGIH (2008)), and for potassium iodide, other than iodine eruption and thyroid lesions, laryngitis, bronchitis, glottal edema, asthmatic attack, salivary gland edema, parotitis, gastritis, along with iodine cachexia such as generalized weakness, palpitation, depression, sleeplessness, and irritability are listed as iodine poisoning (Ethical Pharmaceuticals 2016). As above, other than skin, thyroid, and respiratory organs, various systemic signs for which it is difficult to identify a target organ were observed. Therefore, the substance was classified in Category 1 (skin, thyroid, respiratory organs, systemic toxicity). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |