Item | Information |
---|---|
CAS RN | 7784-18-1 |
Chemical Name | Aluminum trifluoride |
Substance ID | H27-B-017/C-038B_P |
Classification year (FY) | FY2015 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2010 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
7 | Flammable solids | Not classified |
- |
- | - | It is non-flammable (GESTIS (Access on June 2015)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is non-flammable (GESTIS (Access on June 2015)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is non-flammable (GESTIS (Access on June 2015)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water from water solubility data measured. Water solubility: 0.559 g/100 mL (HSDB (Access on June 2015)). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound that does not contain oxygen but contains halogen (F), but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
From a reported LD50 value of 103 mg/kg for mice (HSDB (Access on June 2015)), it was classified in Category 3. Besides, there is the information of an LD50 value of > 2,000 mg/kg for rats (GESTIS (Access on June 2015)), but its source is unknown. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, there is the information of an LC50 value (4 hours) of 0.53 mg/L for rats (GESTIS (Access on June 2015)), but its source is unknown. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Because it is written that this substance is severely irritating to eyes (HSDB (Access on June 2015)) and severely irritating to tissues (HSDB (Access on June 2015)), it was classified in Category 2. Besides, it is also written in List 3 information that this substance is irritating to eyes (GESTIS (Access on June 2015)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, asthmatic signs by irritant particles were reported in the occupational exposure of handling this substance and aluminum sulfate (EHC 194 (1997)). |
4 | Skin sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. There are no in vivo data, and as for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on August 2015)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, ACGIH classified aluminum metal and its insoluble compound, and fluorides in A4 respectively (ACGIH (7th, 2001) Fluorides, HSDB (Access on June 2015)). |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
Data usable for classification were not obtained from List 1 information source, but a teratogenicity test result is written in HSDB of List 2. It is reported that in a teratogenicity test in pregnant rats in inhalation exposure to this substance through a gestation period, increased pre-implantation mortality of fertilized ova at 0.03-0.2 mg/m3 and fetal toxicity and teratogenicity at a higher concentration occurred, but there is no information on maternal toxicity (HSDB (Access on June 2015)). It is difficult to confirm the details of the original literature written in Russian (Lenchenko, V.G. et al. (1974)), but by considering that the report suggests serious reproductive toxicity effects such as embryonic death and malformation from an extremely low concentration, the substance was classified in Category 2 only from this one report in this hazard class. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
From the data that this substance is irritating to the respiratory tract and causes nasal bleeding and vomiting (HSDB (Access on June 2015)), it was classified in Category 3 (respiratory tract irritation). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (bone) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There are no data on this substance. This substance is used as an additive in aluminum refining. In an epidemiological survey of workers exposed to fluorides in aluminum refining, the majority of 107 employees exposed to relatively high concentrations (2.4-6.0 mg/m3) developed fluorosis after 10-year exposure and showed moderate to severe osteosclerosis with the limitation of dorsal spine mobility after 15 years (ACGIH (7th, 2001) Fluorides). Moreover, it is reported that workers in occupational exposure to fluorides did not show bone lesions at an average concentration of 2.65 mg/m3, but developed bone changes at an average concentration of 3.38 mg/m3 (ACGIH (7th, 2001) Fluorides). Therefore, it was classified in Category 1 (bone). Besides, effects on teeth by this substance were not reported, but it became evident that excessive ingestion of fluorine affects mainly skeletal tissues (bones and teeth). On top of that, dental fluorosis only occurs in tooth developing stage from birth to 6 or 8 years of age unlike bones (IPCS 227 (2002)), and concentrations above 1.5 mg/L of the WHO Guideline value for drinking water quality carry an increased risk of dental fluorosis, and much higher concentrations could lead to skeletal fluorosis (WHO (2011) Guidelines for drinking-water quality, 4th ed.), therefore, it is thought that this substance possibly affects teeth in children. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |