GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 123-38-6 |
| Chemical Name | Propionaldehyde |
| Substance ID | H27-B-010/C-031B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 2 |
 Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -30 degrees C (closed cup) and a boiling point of 48 degrees C (HSDB (Access on June 2015)), it was classified in Category 2. It is classified in class 3, PGII in UNRTDG (UN1275). |
| 7 | Flammable solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 207 degrees C (HSDB (Access on June2015)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for a liquid with a low boiling point. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From reported LD50 values of 800-1,600 mg/kg (SIDS (2007), ACGIH (7th, 2002)), 1,410 mg/kg (SIDS (2007)), 2,000 mg/kg (males), and 1,700 mg/kg (females) (SIDS (2007), ACGIH (7th, 2002)) for rats, it was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Four LD50 values of 2,000 mg/kg (males), 2,500 mg/kg (females) (SIDS (2007), ACGIH (7th, 2002)), 5.0 mL/kg (4,036 mg/kg) (SIDS (2007)), and 5.0 mL/kg (4,036 mg/kg) (ACGIH (7th, 2002)) were reported for rabbits. It was classified as "Not classified" (Category 5 in UN GHS classification) to which most of the data (3) correspond. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
From a reported LC50 value (30 minutes) of 26,000 ppm (converted to a 4-hour equivalent: 9,200 ppm) (SIDS (2007), ACGIH (7th, 2002)) for rats, it was classified in Category 4. Besides, a reference value in the unit of ppm was applied as vapour without mist because the LC50 value is lower than 90% of the saturated vapour pressure concentration (420,000 ppm). |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In 2 skin irritation tests using rabbits (OECD TG404, GLP compliance or EPA TSCA Guideline, GLP compliance) in application of 0.5 mL undiluted this substance, in the former test, slight erythema was observed but resolved within 24 hours (BUA 195 (1996)), and in the latter test, moderate to severe irritation with necrosis was found and persisted after 14 days in 4/6 animals (SIDS (2007), ACGIH (7th, 2002)). Moreover, it is reported that in other skin irritation tests using rabbits, marked erythema was observed in 1/5 animal after application of 0.01 mL undiluted this substance (SIDS (2007), ACGIH (7th, 2002)), and it is reported that slight to severe irritation was found after 24-hour occlusive application of undiluted this substance, and PII (primary irritation index) was 3.9 (ACGIH (7th, 2002)). Furthermore, it is reported that in an irritation test using guinea pigs, severe irritation was observed, but there is no description on recovery (SIDS (2007), ACGIH (7th, 2002)). Moreover, it is reported that in a report in humans, 12 Asian volunteers were patch tested with this substance for 5 minutes, and severe erythema in 5 persons and weak erythema in 7 were found (ACGIH (7th, 2002)). From the above results, the substance was judged to be Category 2. Besides, it is classified in "Skin Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on June 2015)). |
| 3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It is reported that after 0.02 mL or 0.005 mL of undiluted this substance was applied into the conjunctival sac of rabbits, severe eye injury in a 0.02 mL application group and moderate irritation in a 0.005 mL application group were observed, but there is no description on recovery (SIDS (2007), ACGIH (7th, 2002)). Moreover, in another report, slight corneal injury, iritis with moderate to severe conjunctival irritation were observed after application of 0.01 mL this substance into the conjunctival sac of rabbits, but they resolved within ten days (SIDS (2007), ACGIH (7th, 2002)). From the above results, it was classified in Category 2. Besides, it is reported that corneal opacity was observed after application of one drop of undiluted this substance into the conjunctival sac of rabbits, and it did not resolve during an observation period (ACGIH (7th, 2002)), but it was not used for the classification due to unknown observation period. The substance is classified in "Eye Irrit. 2 H319" in EU CLP classification (ECHA CL Inventory (Access on June 2015)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, it a micronucleus test in mouse bone marrow cells was negative (SIDS (2007), ACGIH (7th, 2002); Food Safety Commission of Japan, Food Additives Assessment Report (2010)). As for in vitro, a negative result of in a bacterial reverse mutation test, negative and positive results in a gene mutation test in cultured mammalian cells, positive results in a chromosomal aberration test, a sister chromatid exchange test, and an unscheduled DNA synthesis test were reported (SIDS (2007); ACGIH (7th, 2002); Food Safety Commission of Japan, Food Additives Assessment Report (2010); IRIS Summary (2008); IRIS Tox. Review (2008); NTP DB (Access on July 2015)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | There is no reproductive toxicity information in humans. As for experimental animals, in a combined repeated dose toxicity study with reproduction/developmental toxicity screening test (OECD TG 422) in rats in an inhalation route, toxic effects on fertility, and effects on survival rate and body weight on day 0 and 4 after birth in F1 offspring were not observed at the dose (maximum 1,500 ppm) where parent animals showed toxicity effects (weight gain reduction (only females), vacuolization and atrophy in the olfactory epithelium of the nasal cavity (males and females)) (IRIS Tox. Rev. (2008), ACGIH (7th, 2002), SIDS (2007)). Moreover, it is reported that in a developmental toxicity test in pregnant rats (7 animals/group) in inhalation exposure during a gestation period (day 0-20 of gestation), lower fetal weight was observed at the dose (2,500 ppm) above the dose (1,000 ppm) where maternal animals showed weight gain reduction. (IRIS Tox. Rev. (2008), ACGIH (7th, 2002), SIDS (2007)) From the above, apparent reproductive/developmental toxicity effects were not detected in the tests using experimental animals, but it is not possible to classify as "Not classified" from the result of the former test alone which is a screening test. Moreover, in the latter, only lower fetal weight is considered to be minimal effects as developmental toxicity effects at the dose where maternal toxicity occurred, and it is judged not to be adopted as evidence for the classification according to the GHS classification guidance for the Japanese government. As above, there is no finding availavle as classification evidence in the known information, but it is judged that data are not sufficient to classify it as "Not classified." Therefore, it was classified as "Classification not possible" in this hazard class. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory organs), Category 3 (narcotic effects) |
 Warning |
H371 H336 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is irritating to the respiratory tract and has narcotic action (ACGIH (7th, 2002)). As for experimental animals, bronchitis, bronchopneumonia, and hyperemia in the liver and kidney were reported after inhalation exposure in rats (ACGIH (7th, 2002)), and the signs were observed at the dose corresponding to Category 2. There is no detailed information about hyperemia in the liver and kidney. From the above, the information to be a target for classification was the effect on respiratory organs and narcotic effects, and it was classified in Category 2 (respiratory system), Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (respiratory organs) |
Warning |
H373 | P260 P314 P501 |
There is no human information. As for experimental animals, in a combined repeated dose/reproductive developmental toxicity test using rats in an inhalation route, vacuolization in the olfactory epithelial cells of the nasal cavity were observed in 52-day inhalation exposure to 150 ppm corresponding to Category 2 (converted to a Guidance value equivalent: 88.3 ppm = 0.21 mg/L (vapour)), and a recovery was found (ACGIH (7th, 2002), IRIS Tox. Review (2008), SIDS (2007)). For an oral route, in a 90-day gavage administration toxicity test using rats, weight gain reduction, necrosis, ulcer, cellular infiltration, or hemorrhage of esophagus to jejunum, decreased sperm cells, degeneration of spermatocytes in testis, lower urine pH, degeneration, necrosis, and basophilic change of tubular epithelial cells were observed at 1,000 mg/kg/day above a range of Category 2 (Food Safety Commission of Japan, Food Additives Assessment Report (2010)). Besides, in the previous classification, on the basis that a combined repeated dose/reproductive and developmental toxicity test in an inhalation route is a screening reproductive toxicity test, and toxicity effects were not observed at 90 ppm in other tests, it was classified as "Classification not possible" due to lack of data. However, this combined repeated dose/reproductive and developmental toxicity test is not a simple screening reproductive toxicity test, but a test in which detection of repeated dose toxicity was also targeted. Moreover, because the test in which toxicity was not observed used exposure conditions of 20-time exposure at 90 ppm which is converted to a value of 0.048 mg/L by exposure conditions, lower than the dose where effects occurred in the combined test, it could not be the rationale to deny the results of the combined test. As above, because vacuolization in the olfactory epithelial cells of the nasal cavity was observed at a concentration corresponding to Category 2 in an inhalation route, it was classified in Category 2 (respiratory system). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, a kinematic viscosity value is calculated to be 0.37 mm2/sec (26.7/25 degrees C) from numerical data (viscosity: 0.3167 mPa*s; density: 0.8657 g/cm3) listed in HSDB (Access on June 2015). |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 96-hour LC50 = 14 mg/L for fish (Pimephales promelas) (SIDS, 2007), it was classified in Category 3. |
| 11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is rapidly degradable (readily degradable: a degradation rate by 28-day BOD = 94%, a degradation rate by TOC = 97%, a degradation rate by GC = 100% (Official Bulletin of Ministry of International Trade and Industry, 1990)), classified in Category 3 for acute toxicity but estimated to be low bioaccumulative (LogPow = 0.59 (PHYSPROP Database, 2009)). |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |