GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 106-98-9 |
| Chemical Name | 1-Butene [alpha-butylene] |
| Substance ID | H27-B-004/C-025B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 2 | Flammable gases (including chemically unstable gases) | Category 1 |
 Danger |
H220 | P210 P377 P381 P403 |
It is classified in class 2.1 in UNRTDG (UN1012) (lower explosion limit 1.6%, upper limit 10% (ICSC (1999))). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not classified |
- |
- | - | It was classified in Flammable gases of class 2.1 in UNRTDG. |
| 5 | Gases under pressure | Liquefied gas |
 Warning |
H280 | P410+P403 | From a critical temperature of 146.5 degrees C (1-butene) (GESTIS (Access on June 2015)) above 65 degrees C, it was classified in liquefied gas (low pressure liquefied gas). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 7 | Flammable solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for gaseous substances. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Gases) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, an LC50 value (4 hours) of > 10,000 ppm for rats was reported for a butene mixture containing 1-butene (0.935 vol%) (trans-2-butene (55.3 vol%), cis-2-buen (42.4 vol%), others (2.2 vol%)) (SIDS (2012)). |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is written that contact with liquid butene could cause frostbite (SIDS (2012)). |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Although there is no detailed information, because it is written that this substance is mildly irritating to eyes (HSDB (Access on June 2015)), it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "classification not possible." As for in vivo, a micronucleus test in mouse red blood cells was negative (ACGIH (7th, 2008)), and as for in vitro, a bacterial reverse mutation test was negative (SIDS (2012)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is reported that in a combined repeated dose toxicity study with reproduction/developmental toxicity screening test (OECD TG 422) in which rats were in inhalation exposure to this substance 2 weeks before mating and through a mating period until day 19 of gestation and maintained by day 4 of nursing, no general and reproductive toxicity effects in parent animals and no developmental effects on offspring by day 4 after birth were observed at the test concentrations up to 8,000 ppm (SIDS (2012), ACGIH (7th, 2008)). However, because this data is screening test results, and there are no other available data obtained, the substance was classified as "Classification not possible" due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | As for experimental animals (rats, mice), there is information that inhalation exposure (17.2-22.7%) to 1-butene caused narcotic effects within 10 minutes, and it is reported that an inhalation exposure to 21-27% (210,000-270,000 ppm) of 1-butene caused asphyxia (ACGIH (7th, 2008), SIDS (2012), PATTY (6th, 2012)). There are no human data. Because asphyxia and narcotic effects mentioned above were due to lack of oxygen in a limited space, it was classified as "Classification not possible." |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There is no human information. As for experimental animals, in a combined repeated dose toxicity study with reproduction/developmental toxicity screening test (OECD TG 422) using rats in an inhalation route, effects were not observed up to the highest dose of 8,000 ppm (converted to a Guidance value equivalent: 3,733 ppm) (SIDS (2012)). The dose is above Category 2 in Guidance values. However, because the test is a screening test, and sufficient data for judgment were not obtained, it was classified as "Classification not possible." |
| 10 | Aspiration hazard | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. Besides, in SIDS, 96-hour EC50 = 12 mg/L for algae, 48-hour EC50 = 19 mg/L for crustacea, and 96-hour LC50 = 18 mg/L for fish (all SIDS, 2012) as QSAR estimation are reported, however, they were not used for the classification. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. Besides, in SIDS, 96-hour chronic value = 1.6 mg/L for algae, 16-day chronic value = 1.2 mg/L for crustacea, and 30-day chronic value = 2.4 mg/L for fish (all SIDS, 2012) are reported as QSAR estimation, however, they were not used for the classification. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |