GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 106-95-6
Chemical Name 3-Bromo-1-propene
Substance ID H27-B-002/C-023B_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive properties.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - "Liquids" according to GHS definition.
3 Aerosols Not applicable
-
-
- - Not an aerosol product.
4 Oxidizing gases Not applicable
-
-
- - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable
-
-
- - "Liquids" according to GHS definition.
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501 		Based on a flash point of -1 degrees C (closed cup) and a boiling point of 71 degrees C (NFPA (13th,2002)), it was classified in Category 2. Besides, it is classified in class 3, subsidiary risk 6.1, PGI in UNRTDG (UN1099).
7 Flammable solids Not applicable
-
-
- - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Type G
-
-
- - Although it contains an unsaturated bond (olefins) in chemical structure, it does not correspond to chemicals of a higher self-reactive property because it is classified in class 3, subsidiary risk 6.1 in UNRTDG (UN1099).
9 Pyrophoric liquids Not classified
-
-
- - It does not ignite spontaneously in contact with air at normal temperatures (an ignition point, 295 degrees C (HSDB (Access on June 2015))).
10 Pyrophoric solids Not applicable
-
-
- - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - It is an organic compound that does not contain oxygen, fluorine, or chlorine.
14 Oxidizing solids Not applicable
-
-
- - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible
-
-
- - Due to no data, the classification is not possible.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501 		From an LD50 value of 120 mg/kg for rats (NTP (2008)), it was classified in Category 3.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Category 3


Danger
H331 P304+P340
P403+P233
P261
P271
P311
P321
P405
P501 		From a reported LC50 value (30 minutes) of 10,000 mg/m3 (2,020 ppm) (converted to a 4-hour equivalent: 714 ppm) for rats (ACGIH (2012)), it was classified in Category 3. Besides, a reference value in the unit of ppm was applied as vapour without mist because the LC50 value is lower than 90% of the saturated vapour pressure concentration (187,000 ppm).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501 		In a skin irritation test using mice, after application of 0.5 mL of this substance (99%) for 3 minutes or 4 hours, erythema and edema were observed after 3-minute application, and erythema did not resolve during an observation period (7 days). A 4-hour application group showed erythema and edema which did not resolve during an observation period, and one animal showed tissue destruction and was killed (ECETOC TR66 (1995)). Besides, it is written that this substance is severely irritating to skin (HSDB (Access on June 2015)). From the above results, it was judged to be classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310 		It is written that this substance is severely irritating to eyes (HSDB (Access on June 2015)). Besides, it was classified in Category 1 in skin irritation/corrosion. From the above results, it was judged to be classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
4 Skin sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible.
5 Germ cell mutagenicity Classification not possible
-
-
- - Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, it is reported that a micronucleus test using peripheral blood after oral administration in 4 mouse strains was negative (NTP (2008), ACGIH (7th, 2012)). As for in vitro, a bacterial reverse mutation test was positive (NTP (2008), ACGIH (7th, 2012)). From the above, although a positive bacterial reverse mutation test, it was judged that this information only could not be a rationale for Category 2.
6 Carcinogenicity Classification not possible
-
-
- - There is no carcinogenicity information in humans. As for experimental animals, in a 40-week gavage administration carcinogenicity test using genetically modified mice of 2 kinds (Tg. AC mice (v-Ha-ras transgenic mice), and p53 haploinsufficient mice), subcutaneous and intracutaneous masses mainly in vulvar area and a slightly increased incidence of squamous epithelial papilloma (histopathologically) were observed in female mice in evaluation system using Tg. AC mice. However, evidence of carcinogenicity was not shown in either male mice of the system or males and females of p53 haploinsufficient mice (NTP (2008), ACGIH (7th, 2012)). From the above, ACGIH classified in A4 (ACGIH (7th, 2012)), and by supporting the classification result by ACGIH, the substance was classified in "the classification is not possible" in this evaluation.
7 Reproductive toxicity Classification not possible
-
-
- - The classification is not possible due to lack of data. Besides, it is written that after 2-week gavage administration in male rats at maximum 60 mg/kg/day, toxic effects were not observed in reproductive organs such as testis (ACGIH (7th, 2012), HSDB (Access on June 2015)).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501 		From the information that this substance is irritating to the respiratory tract in humans (ACGIH (7th, 2012), HSDB (Access on June 2015)), it was classified in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - The classification is not possible due to lack of data.
In a 14-day gavage administration toxicity test using rats, stomach inflammation was observed (ACGIH (7th, 2012)). In a 14-day gavage administration toxicity test using mice, focal degeneration/hyperplasia in mucous epithelium of forestomach was found (NTP (2008)). Because these were considered to be findings by irritation, they were not used for the classification.
10 Aspiration hazard Classification not possible
-
-
- - Due to lack of data, the classification is not possible.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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