GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 463-58-1 |
| Chemical Name | Carbonyl sulphide |
| Substance ID | H27-A-012/C-012A_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 2 | Flammable gases (including chemically unstable gases) | Category 1 |
 Danger |
H220 | P210 P377 P381 P403 |
It is classified in class 2.3, subsidiary risk 2.1 in UNRTDG (UN2204) (explosion limits 12 to 29% (ACGIH (7th, 2012))). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not classified |
- |
- | - | It is classified in class 2.3, subsidiary risk 2.1 in UNRTDG (UN2204) and is flammable gases. |
| 5 | Gases under pressure | Liquefied gas |
 Warning |
H280 | P410+P403 | From a critical temperature (102 degrees C (GESTIS (Access on June 2015))) of above 65 degrees C, it was classified in liquefied gas (low pressure liquefied gas). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 7 | Flammable solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for gaseous substances. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Gases) | Category 3 |
 Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
From reported LC50 values (4 hours) of 590 ppm and 1,082 ppm for rats (ACGIH (7th, 2012)), it was classified in Category 3. |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. No in vivo data. As for in vitro, it is reported that a bacterial reverse mutation test was weakly positive (NTP DB (Access on June 2015)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Due to no classification result by other organization and lack of data, the classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is written that a decreased pregnancy rate was observed in a test in which male rats were mated with unexposed females after inhalation exposure for ten weeks (draft ATSDR (2014)). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |
 Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
There is not many pieces of information on this substance. However, in inhalation exposure in rats (not less than 1,096 ppm), central nervous system disorder such as convulsions, hypoactivity, and dyspnea was reported. It is written that principal target organ in acute toxicity is the brain, especially cerebellum, and central nervous system is affected by acute exposure (ACGIH (7th, 2012), HSDB (Access on June 2015), draft ATSDR (2014)). The doses in the above inhalation exposure in rats correspond to Category 1 in Guidance values. Therefore, the substance was classified in Category 1 (central nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system) |
Warning |
H373 | P260 P314 P501 |
There is no information in humans. As for experimental animals, in a 12-week inhalation toxicity test using rats, the following effects on the central nervous system were observed: decreases in cytochrome oxidase activity at 200 ppm (converted to a Guidance value equivalent: 133.3 ppm) or higher (week 3,6,12); and decreased brainstem auditory-evoked potential at 300 ppm (converted to a Guidance value equivalent: 200 ppm) or above. These doses are within the range of Category 2. Besides, changes in functional observation battery (FOB) and latency of somatosensory-evoked potentials, a histopathological change, and changes in magnetic resonance microscopy (MRM) (multiple hypointense areas in posterior thalamic nuclear group, hypothalamus, and posterior colliculus) were observed at 400 ppm (converted to a Guidance value equivalent: 266.7 ppm) that is the dose above Category 2 (ACGIH (7th, 2012)). Therefore, the substance was classified in Category 2 (central nervous system). |
| 10 | Aspiration hazard | Not applicable |
- |
- | - | "Gases" according to GHS definition. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |