GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 590-18-1
Chemical Name cis-2-Butene
Substance ID H27-A-002, C-002A_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  "Gases" according to GHS definition.
2 Flammable gases (including chemically unstable gases) Category 1


Danger
H220 P210
P377
P381
P403
 It is classified in class 2.1 in UNRTDG (UN1012) (1.7 to 9.0“(ICSC (1996))).
3 Aerosols Not applicable
-
-
- -  Not an aerosol product.
4 Oxidizing gases Not classified
-
-
- -  It is classified in class 2.1 in UNRTDG (UN1012) and flammable gases.
5 Gases under pressure Liquefied gas


Warning
H280 P410+P403  From a critical temperature (162.4 degrees C) (GESTIS (Access on June 2015)) above 65 degrees C, it was classified in liquefied gas (low pressure liquefied gas).
6 Flammable liquids Not applicable
-
-
- -  "Gases" according to GHS definition.
7 Flammable solids Not applicable
-
-
- -  "Gases" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  "Gases" according to GHS definition.
9 Pyrophoric liquids Not applicable
-
-
- -  "Gases" according to GHS definition.
10 Pyrophoric solids Not applicable
-
-
- -  "Gases" according to GHS definition.
11 Self-heating substances and mixtures Not applicable
-
-
- -  "Gases" according to GHS definition.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  "Gases" according to GHS definition.
13 Oxidizing liquids Not applicable
-
-
- -  "Gases" according to GHS definition.
14 Oxidizing solids Not applicable
-
-
- -  "Gases" according to GHS definition.
15 Organic peroxides Not applicable
-
-
- -  "Gases" according to GHS definition.
16 Corrosive to metals Classification not possible
-
-
- -  No established test method suitable for gaseous substances.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not applicable
-
-
- -  "Gases" according to GHS definition.
1 Acute toxicity (Dermal) Not applicable
-
-
- -  "Gases" according to GHS definition.
1 Acute toxicity (Inhalation: Gases) Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 An LC50 value (4 hours) of > 10,000 ppm for rats was reported for a mixture consisting of trans-2-butene (55.3 vol%), cis-2-butene (42.4 vol%) and others (n-butane, 1-butene, and so on) (2.3 vol%) (SIDS (2012)).
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  "Gases" according to GHS definition.
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable
-
-
- -  "Gases" according to GHS definition.
2 Skin corrosion/irritation Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 Besides, there is the information that a liquefied product of 2-butene could cause frostbite in direct contact with skin (SIDS (2012)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 Besides, there is the information that 1-butene is mildly irritating to eyes (HSDB (Access on June 2015)).
4 Respiratory sensitization Classification not possible
-
-
- -  Due to lack of data, the classification is not possible.
4 Skin sensitization Classification not possible
-
-
- -  Due to lack of data, the classification is not possible.
5 Germ cell mutagenicity Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 Besides, as in vitro data on an isomer mixture, 2-butene was reported to be negative in a bacterial reverse mutation test and a chromosomal aberration test using rat peripheral blood lymphocytes (SIDS (2012), ACGIH (7th, 2001)).
6 Carcinogenicity Classification not possible
-
-
- -  For this substance, no carcinogenicity test was reported and no classification was internationally conducted.
 Therefore, the classification is not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  There is no report on reproductive/developmental effects by exposure to this substance only.
 Besides, in a combined repeated dose toxicity study with reproduction/developmental toxicity screening test (OECD TG 422) using rats with an inhalation route on 2-butene (a mixture of cis- and trans-isomers), no effect on fertility of parent animals and growth of the offspring until four days after birth were observed (SIDS (2012), ACGIH (7th, 2008)). However, because it is a screening test, the classification is not possible due to lack of the information with only this result.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  As for experimental animals (mice), there is the information that inhalation exposure to this substance (17.2 vol%) caused narcotic effects within 10 minutes and it was reported that an inhalation exposure to this substance of 25.5 vol% (255,000 ppm) caused asphyxia (ACGIH (7th, 2008), SIDS (2012), PATTY (6th, 2012)).
 Because asphyxia and narcotic effects mentioned above were due to lack of oxygen in a limited space, it was classified as "Classification not possible."
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  No repeated dose toxicity data on this substance.
 Toxicity information by an inhalation route of experimental animals was obtained on 2-butene (a mixture of cis- and trans-isomers). In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test using rats (OECD TG 422), no effect was observed up to the highest dose of 5,000 ppm (SIDS (2012)). This dose is above a guidance value range of Category 2 and corresponds to "Not classified," however, the classification is not possible because the test is a screening test.
 Therefore, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Not applicable
-
-
- -  "Gases" according to GHS definition.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
 Besides, in SIDS, 96-hour EC50 = 14 mg/L for algae, 48-hour EC50 = 22 mg/L for crustacea and 96-hour LC50 = 20 mg/L for fish as QSAR estimation are reported (all SIDS, 2012), however, they were not used for the classification.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
 Besides, in SIDS, a 96-hour chronic value = 1.7 mg/L for algae, a 16-day chronic value = 1.3 mg/L for crustacea and a 30-day chronic value = 2.8 mg/L for fish as QSAR estimation are reported (all SIDS, 2012), however, they were not used for the classification.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals iGHSj in United Nations.

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