GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 83-32-9
Chemical Name Acenaphthene
Substance ID H27-B-01-METI/M-021B_P
Classification year (FY) FY2015
Ministry who conducted the classification Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 450 deg C (ICSC (2006)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - Based on reported LD50 values for rats of > 2,000 mg/kg (OECD TG 401) (SIDS (2011), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), JECDB (Access on November 2015)), 10,000 mg/kg and > 16,000 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)), it was classified as "Not classified."
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a description that this substance is irritating to the skin and mucous membrane (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), HSDB (Access on October 2015)), but since the details such as references are unknown, it was judged that it was insufficient data for use in the classification.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a description that this substance is irritating to the mucous membrane (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), HSDB (Access on October 2015)), but since the details such as references are unknown, it was judged that it was insufficient data for use in the classification.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in bacterial reverse mutation tests and positive in a chromosomal aberration test with mammalian cultured cells (JECDB (Access on November 2015), SIDS (2011), NTP DB (Access on November 2015), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)).
IUCLID data which were used in the previous classification could not be confirmed.
6 Carcinogenicity Classification not possible
-
-
- - As for the carcinogenicity of this substance, there is a description that tumor development was not shown as a result of dermal application to mice for nine months, where a 90% benzene solution was used as the medium, but there are no test reports on other routes (IARC 92 (2010)). As for the classification results by other organizations, IARC classified it in Group 3 (IARC Vol. 92 (2010)). From the above, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in a 90-day repeated dose toxicity test with mice, effects on the genetic organs (ovary, uterus) in females were observed at doses exceeding Category 2 (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), IRIS Summary (1990)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - There is no human data on this substance. As for experimental animals, toxic symptoms were not seen in oral administration (test at up to 2,000 mg/kg) to rats (JECDB (Access on November 2015), SIDS (2011), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). From the above, since there is no data to allocate a category, it was classified as "Classification not possible."
9 Specific target organ toxicity - Repeated exposure Category 2 (liver)


Warning
H373 P260
P314
P501
No reports are available on humans.
As for experimental animals, in a 28-day oral dose toxicity test with rats dosed by gavage, effects were observed in the group dosed at 60-300 mg/kg/day (converted guidance value: 18.7-93.3 mg/kg/day), which is within the range for Category 2, and as findings in the group dosed at 300 mg/kg/day, an increase in total cholesterol, an increase in liver weight, and centrilobular hypertrophy of the hepatocytes were observed in females and males, and increases in total bilirubin and phospholipid, a transient decrease in food consumption in the early stage of the administration, and increased acidophilic corpuscles of the renal tubular epithelium in males, and increased phospholipid in females were observed (JECDB (Access on November 2015), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2011)).
Eosinophilic corpuscles of the renal tubular epithelium found in males in the above test were not included in the evidence of the classification for specific target organ toxicity (repeated exposure) because it has poor toxicological significance due to the specific findings for male rats.
From the above, effects on the liver were seen within the range for Category 2.
Therefore, it was classified in Category 2 (liver).
10 Aspiration hazard Classification not possible
-
-
- - Although it is a hydrocarbon, there are no case reports of respiratory hazard due to aspiration, and it is also impossible to calculate the kinematic viscosity due to lack of data. Therefore, classification was not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
From 96-hour LC50 = 0.25 mg/L for crustacea (Mysidopsis bahia) (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
Due to being not rapidly degradable (a degradation rate by BOD: 0%, non-biodegradable (Official Bulletin of Ministry of International Trade and Industry, 1990)), and 30-day NOEC (growth) = 0.0775 mg/L for fish (Pimephales promelas, embryo) (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)), it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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