GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 135-19-3 |
| Chemical Name | beta Naphthol |
| Substance ID | H27-B-15-METI/M-015B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, there is the information that it is combustible (ICSC (2005)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 550 deg C (ICSC (2005)). |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on reports of LD50 values of 1,320 mg/kg (OECD TG401) (SIDS (2006)), 1,960 mg/kg, and 1,980 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)) for rats, this substance was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there are reports of LD50 values for rats and rabbits that were both > 10,000 mg/kg (SIDS (2006)), but the details were not clear. Therefore, this substance was classified as "Classification not possible." Besides, in this reclassification, the category was changed due to revising the information source. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
Based on a report of an LC50 value (4 hours) of 2.2 mg/L (OECD TG403) for rats (SIDS (2006)), this substance was classified in Category 4. Based on a description that the test was performed with the aerosol, the reference value for dusts and mists was used. Besides, there was another report of an LC50 value (1 hour) of > 0.77 mg/L (converted 4-hour equivalent value: 0.1925 mg/L) for rats (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is described that, in a skin irritation test with rabbits (OECD TG 404), after 500 mg of this substance was applied under semi-occlusive conditions for 4 hours, the Draize score was 0 (SIDS (2006)). From the above, this substance was classified as "Not classified." |
| 3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It was reported that in an eye irritation test with rabbits, conjunctivitis, corneal opacity, and iritis were observed on the application of this substance (100 mg), and severe eye irritation was seen (SIDS (2006)). In addition, it was reported that an increased incidence of conjunctivitis was observed among workers exposed to this substance (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). From the above, this substance was classified in Category 2A. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In a maximization test with 10 guinea pigs (OECD TG406 GLP-compliant), this substance was reported to be sensitizing (100% positive) (SIDS (2006)). Additionally, this substance was reported to be positive in a separate sensitization test with guinea pigs (SIDS (2006)). As for occupational exposures, it was reported that contact dermatitis was observed in 21 out of 303 workers who had handled this substance (SIDS (2006), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). From the above, this substance was classified in Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, this substance was negative in a micronucleus test with bone marrow cells of mice dosed by gavage (JECDB (Access on November 2015), SIDS (2006)). As for in vitro, this substance was negative in bacterial reverse mutation tests (SIDS (2006)). Besides, the category was changed by revising the GHS classification guidance for the Japanese government and the information sources. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Since there are no classification results by other organizations, classification was not possible due to lack of data. Besides, it is described that in a two-stage carcinogenicity study with female mice applied transdermally, promoter action by this substance was not detected (SIDS (2006)). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a one-generation reproduction toxicity study, in which this substance was administered by gavage to male rats for 98 days including 10 weeks prior to mating and during the mating period, and to female rats from 2 weeks prior to mating, during mating and pregnancy, and until day 20 of lactation, in the parental animals, symptoms such as decreased motility, salivation, and nasal discharge were seen in both males and females at or above 40 mg/kg/day, however, at up to the high dose of 160 mg/kg/day, no abnormality in copulation, pregnancy, and delivery was seen, and no histopathological changes were found in the reproductive organs of males and females (JECDB (Access on November 2015), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). However, it was described that at 160 mg/kg/day, while no clear signs of abnormal nursing behavior was seen in the dams, a trend toward a decrease in birth index, a reduced viability index at day 4 after birth, reduced litter sizes, and slightly suppressed growth by day 21 after birth were observed in the pups of this group, and it is reported that there were no effects caused by adverse effects on the dams but effects on genesis/postnatal development of the offspring were shown (JECDB (Access on November 2015), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). Regarding this data, it was noted in SIDS that depressed activity was observed in the dams at 160 mg/kg/day, suggesting the neonatal deaths were caused by the possibility of suppression of nursing capability, and 160 mg/kg/day was thereby judged to be a dose causing a reproductive effect (suppression of nursing capability) (SIDS (2006)). The judgment is dependent on the information source as to whether the cause of neonatal deaths at 160 mg/kg/day was due to nursing disorders in the maternal animals or not. Other than this, there was no further information available for classification of this substance for the reproductive effects, and there was no data from developmental toxicity tests with pregnant animals. Therefore, this substance was classified as "Classification not possible" due to lack of data for this hazard class. Besides, the category was changed due to the addition of the new information sources in this reclassification. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, haemal system, kidney), Category 3 (respiratory tract irritation) |
 Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
As for humans, it was reported that this substance caused nausea, vomiting, abdominal pain, diarrhea, convulsions, hemolytic anemia, and kidney damage by oral ingestion, cough, sore throat by inhalational exposure, and kidney damage, corneal and lens opacities, and hyperemia of the ocular fundus by transdermal exposure (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009), HSDB (Access on November 2015)). In experimental animals, reduced activity, exhaustion, irregular respiration, diarrhea, and eyelid closure were observed in the oral dose (1320 mg/kg bw, equivalent to Category 2) in rats, and irregular respiration, reduced activity, and impaired motility and reflexes were observed in inhalational exposure (2.2 mg/L, equivalent to Category 2) of rats (SIDS (2006)). From the above, this substance causes the effects on the central nervous system, haemal system, and kidney, in addition to respiratory tract irritation. Therefore, it was classified in Category 1 (central nervous system, haemal system, kidney) and in Category 3 (respiratory tract irritation). Besides, the category was changed by revising the GHS classification guidance for the Japanese government or information sources. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, liver, kidney, urinary bladder, haemal system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
As for human, while the details were unknown, it is reported that impairment of kidney function with dysuria, nephrosis, and inflammation of the urinary bladder were observed in 303 workers (140 men and 163 women) who were exposed at 1-200 mg/m3, and increased incidences of gastritis, chronic hepatitis, impairment of the nervous system, and effects on the blood (increased reticulocyte count, decreased leukocyte count, etc.) were also seen (SIDS (2006), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). As for experimental animals, it is reported in a study where rats were exposed by inhalation for 1-4 months, impairment of the function of the liver and kidney and blood clotting were observed (SIDS (2006)). However, this description was insufficient to be used for the rationale of the classification. From the above, although the details were unknown, it is reported that effects mainly on the kidney but also on the urinary bladder, liver, nervous system, and haemal system were seen in humans. Therefore, it was classified in Category 1 (nervous system, liver, kidney, urinary bladder, haemal system). Besides, in this reclassification, the classification result was changed because effects on organs other than the kidney were described in the information source which was also used in the previous classification, and a similar description was found in a newly added information source. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 | P273 P391 P501 |
From 48-hour LC50 = 0.85 mg/L for crustacea (Gammarus minus) (SIDS, 2006), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Due to being rapidly degradable (a degradation rate by 2-week BOD = 68.4%, a degradation rate by TOC = 73.0%, a degradation rate by GC = 100% (Official Bulletin of Ministry of International Trade and Industry, 1976)), and 27-day NOEC = 0.001 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2006), it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |