Item | Information |
---|---|
CAS RN | 7722-64-7 |
Chemical Name | Potassium permanganate(VII) |
Substance ID | H26-B-148, R-133 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2003)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | It is classified in Division 5.1, Subsidiary Risk 8, PG II (UN1490) in UNRTDG and is classified as oxidizing solids. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2003)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2003)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility: 6.4 g/100 mL (20 deg C) (ICSC (2003)) were obtained, it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
14 | Oxidizing solids | Category 2 |
Danger |
H272 |
P370+P378
P210 P220 P221 P280 P501 |
Because it is classified in Division 5.1, Subsidiary Risk 8, PG II (UN1490) in UNRTDG, it was classified in Category 2. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P362+P364 P264 P270 P330 P501 |
Based on the reports of LD50 values of 379 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) and 750 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EHC 17 (1981)) for rats, it was classified in Category 4. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Although there is no specific information, there are descriptions that this substance was highly corrosive and it was irritating (HSDB (Access on December 2014)). From the above, it was classified in Category 1 due to the descriptions that it was corrosive. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
Although there is no specific information, there are descriptions that this substance was highly corrosive and it was irritating (HSDB (Access on December 2014)). In addition, this substance was classified in Category 1 for Skin Corrosion/Irritation. From the above, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 |
P308+P313
P201 P202 P280 P405 P501 |
As for in vivo, it was positive in a mouse bone marrow micronucleus test and a chromosomal aberration test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), PATTY (6th, 2012), ATSDR (2012)). As for in vitro, there are negative and positive results in chromosomal aberration tests with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). From the above, it was classified in Category 2. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In toxicity studies with rats by the oral or inhalation route, effects on spermatogenesis and fetuses were observed although there is no description of general toxicity for parental animals (EHC 17 (1981)). Details on the observed effects are unknown. Although it is not data on this substance, but as data on manganese chloride, which is water-soluble like this substance, in a study where male mice were administered with drinking water for 12 weeks before mating with an untreated female, inhibition of insemination in males was observed in the 309 mg/kg/day group. In the control group, 26 out of 28 females mated with males became pregnant, whereas in the 309 mg/kg/day of manganese chloride group, 17 out of 28 females mated with males became pregnant (ATSDR (2012)). In a developmental toxicity study in which pregnant rats were administered by gavage, although maternal toxicity was not described, an increase in post-implantation resorption was observed at the highest dose (33 mg manganese/kg/day) (ATSDR (2012)). In a developmental toxicity study by subcutaneous injection to pregnant mice, the survival rate of pups at the postnatal day 4 was significantly decreased in the 2 mg/kg/day group, in which no effects on the body weight of maternal animals were observed, and extensions of periods until eye opening and testicular descent were also observed. However, there was no decline in either activity or learning ability when the surviving pups became adults (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014)). Therefore, it was classified in Category 2 based on comprehensive judgment from the data of this substance and the data on manganese chloride. Besides, the Japan Society For Occupational Health (JSOH) classifies manganese and manganese compounds as reproductive toxicants Group 2 (provisional) (corresponding to Category 1B) in the OEL Documentations (2014). However, the classification of OEL Documentations was not adopted because it is in a provisional period. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There are very few human data of this substance. It is reported that this substance showed respiratory tract irritation (PATTY (6th, 2012)), and that in a case of a child who accidentally ingested 174 mg/kg, no systemic effects were found, but necrosis was observed in the mouth, esophagus, and stomach due to irritation (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). There are no experimental animal data. Besides, fume fever was observed by acute exposure to not this substance but manganese fume (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, pulmonary inflammatory reactions caused by acute inhalation exposure to manganese dusts (especially MnO2 and Mn3O4) led to impaired lung function over time. There is a report that lung toxicity increased susceptibility to infections such as bronchitis, resulting in the development of manganic pneumonia (CICAD 12 (1999)). The data on manganese fume and dust were not adopted because of the differences in physical properties between them and this substance. From the above, although the data on this substance are very limited, it showed respiratory tract irritation and was classified in Category 3 (respiratory tract irritation). The category of the previous classification was revised. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There is a report that since in a man who mistakenly ingested this substance at low dose (1.8 mg/kg) for several weeks instead of potassium iodide to treat pulmonary congestion, weakness and impaired mental capacity were observed, the ingestion was stopped after 4 weeks, however, about 9 months later, symptoms similar to Parkinson's disease developed (CICAD 12 (1999), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Therefore, this is a case that like manganese dioxide, a typical manganese compound, this substance also caused neurotoxicity as manganese poisoning. Other than this, although no clear reports of repeated exposures to this substance are available for either humans or experimental animals and there is no direct information on the target organs by inhalation exposure, it is revealed in many reported cases that manganese compounds mainly manganese dioxide caused respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)). From the above, this substance was also classified in Category 1 (nervous system, respiratory system) like manganese dioxide (CAS RN: 1313-13-9). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.185 mg/L (0.0765 mgMn/L) for crustacea (Diaptomus forbesi) (Environmental Risk Assessment for Chemical Substances Vol. 6 (Ministry of the Environment, 2008)). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. Because environmental dynamics of the inorganic compound are unknown, and the substance was classified in Category 1 in acute toxicity, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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