GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 13765-19-0
Chemical Name Calcium chromate
Substance ID H26-B-145, R-091
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Not classified
-
-
- - It is not combustible (dihydrate) (HSDB (Access on December 2014)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- - It is not combustible (dihydrate) (HSDB (Access on December 2014)).
11 Self-heating substances and mixtures Not classified
-
-
- - It is not combustible (dihydrate) (HSDB (Access on December 2014)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - Because data of water solubility: 16.3 g/100 mL (20 deg C) (dihydrate) (HSDB (Access on December 2014)) were obtained, it is estimated that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Classification not possible
-
-
- - It is an inorganic compound containing oxygen (but not halogen). Because it is a chromate, it is estimated to be oxidizing, but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P361+P364
P264
P270
P321
P330
P405
P501
Based on LD50 values for rats of 108 mg/kg (female) and 249 mg/kg (male) (ATSDR (2012)), it was classified in Category 3.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
Although there are no concrete test reports, etc., there are many reports describing that hexavalent chromium compounds were corrosive (EU-RAR (2005), DFGOT vol.3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). Since this substance is water-soluble Cr (VI) and was considered to cause irritation equivalent to hexavalent chromium compounds, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Although there are no concrete test reports, etc., there are many reports describing that hexavalent chromium compounds were corrosive (EU-RAR (2005), DFGOT vol.3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). Since this substance is water-soluble Cr (VI) and was considered to cause irritation equivalent to hexavalent chromium compounds, it was classified in Category 1.
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501
The Japan Society for Occupational Health (JSOH) classified chromium compounds in occupational sensitizers to the airway Group 2. Although this substance is not specified in this classification, there is a description in OEL Documentations (Japan Society For Occupational Health (JSOH), 1989) that hexavalent chromium compounds are more toxic than divalent and trivalent compounds. In addition, there is a description that chromium compounds caused asthma (ATSDR (2012), EU-RAR (2005)). From the above, it was classified in Category 1.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
Chromium compounds including this substance were classified in occupational skin sensitizers Group 1 by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2014)). Although this substance is not specified in this classification, there is a description that hexavalent chromium compounds are more toxic than divalent or trivalent compounds in the OEL Documentations (Japan Society For Occupational Health (JSOH), 1989). In addition, although it is not information limited to this substance, there is a description that hexavalent chromium compounds were sensitizing to the skin (EU-RAR (2005), ATSDR (2012), PATTY (6th, 2012)). Moreover, there is a report that sensitization was observed in a human patch test with hexavalent chromium compounds (ATSDR (2012)). From the above, it was classified in Category 1.
5 Germ cell mutagenicity Category 1B


Danger
H340 P308+P313
P201
P202
P280
P405
P501
As for in vivo, although it was negative in micronucleus tests with mice and hamsters, it was positive in a sister chromatid exchange test (animal species unknown) (IARC 49 (1990)). As for in vitro, it was positive in all of bacterial reverse mutation tests, mouse lymphoma tests, a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells (ACGIH (7th, 2001), ATSDR (2012), IARC 49 (1990), NTP DB (Access on Dec 2014)). Although there are no data of either in vivo germ cell mutagenicity or in vivo genotoxicity relating to this substance, since this substance is water-soluble Cr (VI), it was classified in Category 1B.
6 Carcinogenicity Category 1A


Danger
H350 P308+P313
P201
P202
P280
P405
P501
Since it was classified in Group 1 (as chromium (VI)) by IARC (IARC (1990)), in A2 by ACGIH (ACGIH (7th, 2001)), as K (as hexavalent chromium compound) by NTP (NTP RoC (2014)) and in Group 1 by Japan Society for Occupational Health (JSOH) (OEL Documentations (1989)), it was classified in Category 1A, giving priority to IARC classification. Besides, it was classified in 2 by the EU (EU (Access on Dec. 2014)).
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
There are no data on this substance.
However, as for reproductive toxicity of chromium (VI), potassium dichromate (CAS: 7778-50-9) and potassium chromate (CAS: 7789-00-6), water-soluble substances just like this substance, were classified in Category 1B. Therefore, this substance was also classified in Category 1B.
Besides, chromium and its compounds were classified in reproductive toxicants Group 3 (provisional) (correspond to Category 2) in Recommendation of Occupational Exposure Limits (2014) by Japan Society For Occupational Health (JSOH). However, because the classification of Recommendation of Occupational Exposure Limits was in a provisional period, it was not adopted.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory organs, cardiovascular system, haemal system, liver, kidney)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
There are no data on this substance.
There are reports that respiratory tract irritation, respiratory tract inflammation, nose and chest pain, cough, dyspnea, cyanosis and kidney damage were observed by human inhalation exposure to hexavalent chromium compounds, that vomiting, diarrhea, gastrointestinal tract bleeding, liver necrosis, and renal tubular necrosis in the kidney were observed by human oral exposure, and that severe respiratory, cardiovascular, gastrointestinal, hematological, hepatic, renal, and neurological effects were reported by accidental or intentional human ingestion at high-doses (ACGIH (7th, 2001), CICAD 78 (2013), EHC 61 (1988), EU-RAR (2005), ATSDR (2012)).

This substance is a hexavalent chromium compound, and it was considered possible to use the toxicity findings on hexavalent chromium compounds for classification of this substance. The findings of the gastrointestinal tract were not adopted because of local irritation.
From the above, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, hemal system, liver, kidney).
The previous classification was changed.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
There are no reports of clear effects by repeated exposure to this substance in either humans or experimental animals. However, in the Hazard Assessment Report of a series of hexavalent chromium compounds including this substance, there is a description that in humans who were exposed occupationally to hexavalent chromium compounds, irritation of the respiratory tract and eyes were observed, which may cause ulcer/perforations in the nasal septum (CICAD 78 (2013)). Therefore, this substance was also classified in Category 1 (respiratory organs) like other hexavalent chromium compounds.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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