GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 75-18-3
Chemical Name Dimethyl sulfide
Substance ID H26-B-134, R-060
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 2 based on a flash point of -48 deg C (closed cup) and a boiling point of 37 deg C (GESTIS (Access on September 2014)).
Besides, it is classified in Class 3, PG II (UN1164) in UNRTDG.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 205 deg C (ICSC (1999)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to low-temperature-boiling liquids are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. The category was revised because evidence data of the previous classification (RTECS) could not be confirmed. Besides, although there is a report of an LD50 value of 535 mg/kg for rats (PATTY (6th, 2012)), it was not adopted for classification due to low reliability described in SIDS Dossier (2007).
1 Acute toxicity (Dermal) Not classified
-
-
- - Based on a report of an LD50 value of >5,000 mg/kg for rabbits (PATTY (6th, 2012), SIDS (2007), ACGIH (7th, 2004)), it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified
-
-
- - Based on a report of an LC50 value (4 hours) of 40,250 ppm for rats (PATTY (6th, 2012), SIDS (2007), ACGIH (7th, 2004)), it was classified as "Not classified." Besides, since the LC50 value was lower than 90% of the saturated vapour concentration (660,526 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Not classified
-
-
- - There are reports that slight irritation was observed after occlusive application of this substance (undiluted) to rabbits for 24 hours (SIDS (2007)), and that when this substance was applied to the skin of rabbits (application time unknown), a primary irritation score of 0.4 (0-8) was obtained, indicating slight irritation (ACGIH (7th, 2004)). In addition, it is described that it is slightly irritating to rabbit skin (PATTY (6th, 2012)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). New information was added (SIDS (2007)), and the classification was revised according to the revised GHS classification guidance for the Japanese government.
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
Based on reports that in tests in which this substance was applied to the eyes of rabbits, changes in the sclera was observed, and there was mild irritation (SIDS (2007)), and minimal to moderate irritation was observed, but all signs of response cleared up after 4 days (ACGIH (7th, 2004)), it was classified in Category 2B. Besides, although the specific information was unknown, it is described that this substance is a severe eye irritant (PATTY (6th, 2012)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2007)). As for in vitro, it was negative in a bacterial reverse mutation test (SIDS (2007), ACGIH (7th, 2004)). From the above, it was classified as "Classification not possible."
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
There is a report that in a teratogenicity study with rats by the oral route (gavage), no maternal toxicity or fetotoxicity was observed even at the highest dose (1,000 mg/kg/day) (SIDS (2007)). However, since there was no sufficient information on fertility, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - There are no human data on this substance. As for experimental animals, although there is little information, there is a description that this substance irritated the mucous membranes, as well as paralyzing the voluntary and respiratory muscles on inhalation exposure to this substance with rats at concentrations of 3-140 mg/L (HSDB (Access on September 2014)). However, the details were unknown.
From the above, it was not possible to classify this substance due to few findings. Therefore, it was classified as "Classification not possible" due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - There are multiple occupational exposure reports that effects on the cardiovascular system, respiratory organs, and nervous system were observed by inhalation exposure to a mixture of volatile sulfur compounds (including other mono- and disulfides, and mercaptans in addition to this substance). However, it is stated that no reliable data were available on the effects of exposure to this substance (ACGIH (7th, 2004)).
As for experimental animals, this substance was orally dosed to rats for 14 weeks, however, no clear toxicity suggesting target organs was observed at the highest dose (250 mg/kg/day) (SIDS (2007), ACGIH (7th, 2004), PATTY (6th, 2012)).
From the above, it is considered to be corresponding to "Not classified" through the oral route. However, there is neither toxicity information through other routes and nor reliable findings in humans, therefore, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 96-hour ErC50 = 23 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2007).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67.4% (SIDS, 2007)), and 21-day NOEC = 8.3 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to 96-hour LC50 > 100 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)), rapid degradability (a 28-day degradation rate: 67.4% (SIDS, 2007)), and a low bioaccumulation estimate (log Kow = 0.92 (PHYSPROP Database, 2009)).
From the above results it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information