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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7553-56-2
Chemical Name	Iodine
Substance ID	H26-B-133, R-059
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2004)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2004)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2004)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Classification not possible	- -	-	-	It is halogen, but the classification is not possible due to no data. Besides, it is described that it is a strong oxidant and reacts with combustible and reducing substances, and that it reacts violently with metal powders, antimony, ammonia, acetaldehyde, and acetylene, generating fire and explosion hazard (ICSC (2004)). However, because it is classified in Class 8, Subsidiary Risk 6.1, PG III (UN3495), and Subsidiary Risk 5.1 is not given, it is estimated to correspond to "Not classified."
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P362+P364 P264 P270 P330 P501	There are 2 reports of LD50 values (EPA TG 870.1100) of 315 mg/kg (EPA Pesticide (2006)) and 14,000 mg/kg (PATTY (6th, 2012)) for rats. Since these data corresponded to Category 4 and "Not classified," respectively, it was classified in Category 4 with the smaller LD50 value. New information sources (PATTY (6th, 2012), EPA Pesticide (2006)) were added, and the category was revised.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value (EPA TG 870.1200) of 3,333 mg/kg for rats, it was classified as "Not classified" (Category 5 in UN GHS classification). A new information source (EPA Pesticide (2006)) was added, and the category was revised.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a report of an LC50 value (EPA TG 870.1300) (4 hours) of 0.363 mg/L (=35 ppm) for rats (EPA Pesticide (2006)), it was classified in Category 1. Besides, although this substance is a solid (GHS definition), in addition to being a sublimate, the LC50 value was lower than 90% of the saturated vapour concentration (4.108 mg/L (=395 ppm)), therefore, the reference value in units of ppm was applied as a vapour without a mist. A new information source (EPA Pesticide (2006)) was added, and the category was revised.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a report that in a test with rats (inhalation exposure), severe oedema, erythema and desquamation were observed and it was corrosive, but these effects are not considered to be severe (EPA pesticide (2006)), and there is a description that this substance is corrosive to the skin (PATTY (6th, 2012)), however, there are no descriptions of the exposure time and irreversible effects. In addition, there is a description that the vapour of this substance was irritating to the skin in humans (PATTY (6th, 2012)) and there is a description that it causes skin blisters as a local effect (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 1993)). From the above results, it was classified in Category 2.
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is a description that the vapour of this substance was irritating to the eyes and eyelids in humans (PATTY (6th, 2012)), and there is a report that it was severely irritating to the mucosa in experimental animals (ACGIH (7th, 2001)). From the above results, it was classified in Category 2.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	This substance was classified in occupational skin sensitizers Group 2 by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2014)). In addition, there are reports of allergic dermatitis (PATTY (6th, 2012)) and of eruption due to allergic reactions (ACGIH (7th, 2001)), therefore, it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in a mouse lymphoma test with cultured mammalian cells (ACGIH (2008), ATSDR (2004), CICAD 72 (2009)).
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified as A4 by ACGIH (ACGIH (2008)), it was classified as "Classification not possible."
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there were no data on this substance, and there were limited data on the reproductive/developmental effects of iodine/iodide in experimental animals. However, human case reports demonstrate that intake of a very high amount of this substance during pregnancy (among these doses, the lowest reported dose of 130 mg/day) may induce neonatal goiter and hypothyroidism (CICAD 72 (2009)).
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	There are reports of respiratory tract irritation, coughing, headache and chest tightness by inhalation exposures to a vapour and a mist of this substance, and abdominal pain, vomiting, diarrhea and gastrointestinal ulceration by the oral ingestion in humans (OEL Documentations (Japan Society For Occupational Health (JSOH), 1968), ACGIH (2008), CICAD 72 (2009), PATTY (6th, 2012), HSDB (Access on September 2014)). There were no data in experimental animals. From the above, since this substance is irritating to the respiratory tract, it was classified in Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Category 1 (thyroid)	Danger	H372	P260 P264 P270 P314 P501	There is a description that chronic intake of excess iodine in humans may result in hypothyroidism or hyperthyroidism (CICAD 72 (2009), ATSDR (2004)) and in extreme cases of more than 8 mg/kg/day (approximately 560 mg/day), it causes hyperthyroidism, etc (ACGIH (2008)). As for experimental animals, when rats with an inbred susceptibility to autoimmune thyroiditis or general-purpose rats treated with thymectomy were administered by drinking water containing 0.05% of iodine for 8 weeks or 12 weeks, respectively, an increase in the incidence of autoimmune thyroiditis characterized by a lymphocytic infiltration, accompanied by increased thyroid weights and increased antibodies to thyroglobulin was observed (CICAD 72 (2009)). In addition, in a test in which rats were given this substance by feeding for 10 weeks, dose-dependent increases in thyroid weights and thyroglobulin antibodies were observed within dose ranges of 0.015-0.23 mg/kg/day (CICAD 72 (2009)). From the above, it was classified in Category 1 (thyroid).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.16 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. Although environmental dynamics of the inorganic compound are unknown, it was classified in Category 1 because it was classified in Category 1 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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