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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	628-63-7
Chemical Name	n-Pentyl acetate (n-Amyl acetate)
Substance ID	H26-B-122, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 25 deg C (closed cup) (ICSC (2000)). Besides, it is classified in Class 3, PG III (UN1104) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 360 deg C (ICSC (2000)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value for rats of 6,500 mg/kg for this substance (PATTY (6th, 2012)) and reports of LD50 values for rats of 12,306 mg/kg (female) and >14,064 mg/kg (male) for a mixture consisting of 65% of this substance and 35% 2-methylbutyl acetate (SIDS (2006), DFGOT vol.11 (1996)), it was classified as "Not classified." Besides, the classification was conducted considering that the toxicity of this substance was equivalent to that of 2-methylbutyl acetate.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on reports of LD50 values of 8,359 mg/kg (male) and > 14,080 mg/kg (female) for rabbits for a mixture consisting of 65% of this substance and 35% 2-methylbutyl acetate (SIDS (2006), DFGOT vol.11 (1996)), it was classified as "Not classified." Besides, the classification was conducted considering that the toxicity of this substance was equivalent to that of 2-methylbutyl acetate.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. When rats were exposed to a mixture consisting of 65% of this substance and 35% 2-methylbutyl acetate, no deaths (0/5 animals) were reported after 4-hour exposure to 976 ppm, and 6-hour exposure resulted in death in 1/5 animals (male) at 3,693 ppm (converted 4-hour equivalent value: 4,523 ppm) and death in 0/5 animals (female) at 3,628 ppm (converted 4-hour equivalent value: 4,443 ppm) (SIDS (2006), DFGOT vol. 11 (1996)), but the category could not be identified from these data. Besides, since the LC50 values were lower than 90% of the saturated vapor concentration (5,656 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the report that there was no death after 4-hour exposure to 6 rats at 5200 ppm = 27.7 mg/L (DFGOT vol.11 (1996)), which was described as evidence in the previous classification, was on a mixture consisted of 65% of this substance and 35% of 2-methylbutyl acetate. And, the saturated vapour concentration of this mixture was 5,656 ppm, therefore, since the test concentration was lower than the saturated vapour concentration, it was judged as inhalation (vapour), and the data were deleted.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although no specific data were available, there is a description that all amyl acetate compounds, including this substance, were irritating to the skin (ACGIH (7th, 2001)), therefore, it was classified in Category 2. In addition, there is a report that no irritation was observed after repeated application of the isomer mixture of this substance to 197 human subjects. Moreover, there is a report that slight irritation was observed after application of an isomer mixture containing this substance to the ears of rabbits, and there is a description that after a 4-hour non-occlusive application of 0.5 mL of the isomer mixture to rabbits, moderate erythema and slight edema were observed and slight desquamation was observed 7 days after application (DFGOT vol. 11 (1996)). Information in ACGIH (7th, 2001) was added and the category was changed.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Since there is a report that after application of this substance to the eyes of rabbits, mild irritation (irritation rating: 2/10) was observed (ACGIH (2001)), it was classified in Category 2B. Besides, although there were no specific data, there is a description that all amyl acetate compounds including this substance were irritating to the eyes (ACGIH (7th, 2001)).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are descriptions that sensitization potential was slight in a maximization test with guinea pigs using an isomer mixture containing 60% of this substance (DFGOT vol.11 (1996)), and that no sensitization was observed in a test in which an isomer of this substance (3-methylbutyl acetate CAS RN; 123-92-2) was applied to 197 human subjects (DFGOT vol. 11 (1996)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test, a gene mutation test, a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells (DFGOT vol. 11 (1998), HSDB (Access on September 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in a teratogenicity test with rats through the inhalation route using a mixture (65% n-pentyl acetate, 35% 2-methylbutyl acetate), although decreased fetal weight and variations (appearance, skeleton, internal organs) occurred at or above doses where maternal toxicity (decreased body weight gain) was observed, no teratogenicity was observed. In addition, in a teratogenicity test with rabbits through the inhalation route, no effects were observed in the fetuses even at the doses where maternal toxicities (decreased body weight gain, decreased food consumption) were observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 2008), SIDS (2006), ACGIH (2001), DFGOT vol. 11 (1998)).
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance was irritating to the respiratory tract (PATTY (6th, 2012), HSDB (Access on September 2014)). In humans, although the route of exposure was unknown, central nervous system depression effects such as dyspnea, nausea, cough, vomiting, diarrhea, headache, ataxia, giddiness, delirium and coma were observed (PATTY (6th, 2012), DFGOT vol. 11 (1998), HSDB (Access on September 2014)). As for experimental animals, central nervous system depression such as narcotic effects, labored breathing, ataxia and loss of righting reflex in rats, mice, etc. were observed (ACGIH (7th, 2001), DFGOT vol. 11 (1998), OEL Documentations (Japan Society For Occupational Health (JSOH), 2008)). From the above, this substance was considered to have respiratory tract irritation and narcotic effects, and it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, the central nervous system depression effects observed with this substance was regarded as narcotic effects.
9	Specific target organ toxicity - Repeated exposure	Category 1 (optic nerve)	Danger	H372	P260 P264 P270 P314 P501	Although there were no reports in either humans or experimental animals in which the effects by repeated exposure to this substance itself were made clear, there were the following findings regarding the effects by exposure to isomer mixtures containing this substance. In humans, there is a report that irritation to the eyes and photophobia were observed in workers exposed to pentyl acetate (details unknown) for 1 month-30 years (ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 2008)). In addition, 30 workers who engaged in film production and were exposed to pentyl acetate mixtures (details unknown) at concentrations of 3,700-14,800 ppm (20-80 mg/L), complained of sensitivity to light, conjunctival irritation and lacrimation at work, and in 4 of them who engaged for 4-9 years, the symptoms were severe, and narrowing of the field of vision and atrophic changes of the visual nerve were observed (DFGOT vol. 11 (1998)). As for experimental animals, there is a description that degeneration of the optic nerve was observed in a test in which rabbits were exposed by inhalation to a pentyl acetate mixture (details unknown) at 7,500 ppm for 60 days (DFGOT vol. 11 (1998)), therefore, it was considered a finding that supported effects on the optic nerve in humans. From the above, it was classified in Category 1 (optic nerve) as well as other isomers since disorder of the optic nerve was observed in pentyl acetate mixtures.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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