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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	123-92-2
Chemical Name	Acetic acid isopentyl (Isoamyl acetate)
Substance ID	H26-B-120, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 25 deg C (closed cup) (ICSC (2000)). Besides, it is classified in Class 3, PG III (UN1104) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 360 deg C (ICSC (2000)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value of 16,600 mg/kg for rats (GESTIS (Access on September 2014) original reference: Yakkyoku. Pharmacy. vol. 32, Pg. 1241, 1981), it was classified as "Not classified."
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there was a report of an LD50 value of >5,000 mg/kg for rabbits (GESTIS (Access on September 2014)), it was an information source in List 3, and it could not be classified since the datum could not be confirmed by an original source. Information sources were changed, and the category was revised.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since there is a description that all amyl acetate compounds including this substance were irritating to the skin (ACGIH (7th, 2001)), it was classified in Category 2. Besides, there is a report that after repeated occlusive application of a 20% solution of this substance to 197 human subjects, no irritation was observed (DFGOT vol. 11 (1996)). In addition, there is a report that slight irritation was observed after application of an isomer mixture containing this substance to the ears of rabbits, and there is a description that after a 4-hour non-occlusive application of 0.5 mL of an isomer mixture to rabbits, moderate erythema and slight edema were observed, and slight desquamation was observed 7 days after application (DFGOT vol. 11 (1996)). Information in ACGIH (7th, 2001) was added and the category was changed.
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there was no specific data, there are descriptions that this substance was irritating to the eyes (HSDB (Access on September 2014)), and that isomers of this substance were irritating to the eyes (ACGIH (2001), DFGOT vol. 11 (1996)). From the above results, it was classified in Category 2. Besides, there is a report that after application of the isomer (1-pentyl acetate) of this substance to the eyes of rabbits, it was slightly irritating (irritation rating: 2/10) to the eyes of rabbits (ACGIH (2001)). The category was changed since adequate information was not obtained for sub-categorization.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report that no sensitization was observed after application of this substance to 197 human subjects (DFGOT vol. 11 (1996)). However, it is described that a considerable loss of the test substance seemed to occur due to evaporation when applied. In addition, there is a description that in a maximization test with guinea pigs using an isomer mixture (including 5% of this substance), the sensitization potential of the isomer mixture containing this substance was slight (DFGOT vol. 11 (1996)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There was no in vivo data. As for in vitro, it was negative in bacterial reverse mutation tests, a mouse lymphoma assay and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2001), DFGOT vol. 11 (1998), NTP DB (Access on October 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance was irritating to the respiratory tract (PATTY (6th, 2012), DFGOT vol. 11 (1998), HSDB (Access on September 2014)). In humans, on inhalation exposure, headache, weakness and central nervous system depression, and at the high concentration unconsciousness were observed (PATTY (6th, 2012), HSDB (Access on September 2014)), and as for experimental animals, on exposure to this substance or the isomer mixtures, central nervous system depression such as narcotic effects, labored breathing, ataxia and loss of righting reflex in rats and mice, etc. were observed (PATTY (6th, 2012), ACGIH (7th, 2001), DFGOT vol. 11 (1998), OEL Documentations (Japan Society For Occupational Health (JSOH), 2008), HSDB (Access on September 2014)). From the above, since this substance was considered to have respiratory tract irritation and narcotic effects, it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, the central nervous system depression effects observed with this substance was regarded as narcotic effects.
9	Specific target organ toxicity - Repeated exposure	Category 1 (optic nerve)	Danger	H372	P260 P264 P270 P314 P501	Although there are no reports in either humans or experimental animals in which the effects by repeated exposure to this substance itself were made clear, there were the following findings regarding the effects by exposure to isomer mixtures containing this substance. In humans, there is a report that irritation to the eyes and photophobia were observed in workers exposed to pentyl acetate (details unknown) for 1 month-30 years (ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 2008)). In addition, 30 workers who engaged in film production and were exposed to pentyl acetate mixtures (details unknown) at concentrations of 3,700-14,800 ppm (20-80 mg/L), complained of sensitivity to light, conjunctival irritation and lacrimation at work, and in 4 of them who engaged for 4-9 years, the symptoms were severe, and narrowing of the field of vision and atrophic changes of the visual nerve were observed (DFGOT vol. 11 (1998)). As for experimental animals, there is a description that degeneration of the optic nerve was observed in a test in which rabbits were exposed by inhalation to a pentyl acetate mixture (details unknown) at 7,500 ppm for 60 days (DFGOT vol. 11 (1998)), therefore, it was considered a finding that supported effect on the optic nerve in humans. From the above, this substance was also classified in Category 1 (optic nerve) as well as other isomers (2-methylbutyl acetate (CAS RN 624-41-9; ID: 121), n-pentyl acetate (CAS RN 628-63-7; ID: 122)) since disorder of the optic nerve was observed in pentyl acetate mixtures.
10	Aspiration hazard	Classification not possible	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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