Item | Information |
---|---|
CAS RN | 141-79-7 |
Chemical Name | Mesityloxid (Mesityl oxide) |
Substance ID | H26-B-112, R-053 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on a flash point of 25 deg C (closed cup) (ICSC (1998)). Besides, it is classified in Class 3, PG III (UN1229) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not classified |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, because it is classified in Class 3, PG III (UN1229) in UNRTDG, it was classified as "Not classified." |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 340 deg C (ICSC (1998)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P362+P364 P264 P270 P330 P501 |
Based on reports of LD50 values of 600 mg/kg (SIDS (2011)), 655 mg/kg (PATTY (6th, 2012)) and 1,120 mg/kg (PATTY (6th, 2012), SIDS (2011), ACGIH (7th, 2001)) for rats, it was classified in Category 4. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on reports of LD50 values of 5,181 mg/kg (PATTY (6th, 2012), SIDS (2011)) and 5,150 mg/kg (SIDS (2011)) for rabbits, it was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 |
P304+P340
P403+P233 P261 P271 P311 P321 P405 P501 |
Based on reports of LC50 values (4 hours) of 1,100 ppm (PATTY (6th, 2012), SIDS (2011)) and 2,241 ppm (SIDS (2011)) for rats, it was classified in Category 3. Besides, because the LC50 values were lower than 90% of the saturated vapor concentration (11,846 ppm), the reference value in units of ppm was applied as a vapor without a mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There are reports that marked irritation occurred when 0.5 mL of this substance was applied to mice (PATTY (6th, 2012)), and that mild irritation was produced in a test in which 430 mg of this substance was applied to rabbits (PATTY (6th, 2012)). In addition, there is a description that the liquid phase of this substance is an irritant (HSDB (Access on September 2014)). From the above, based on the result of "marked irritation," it was classified in Category 2. |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
There is a report that severe irritation was caused by application of 0.5 mL of this substance to rabbits (PATTY (6th, 2012)). In addition, there is a report that eye irritation was observed in humans exposed to 25 ppm of this substance (PATTY (6th, 2012), ACGIH (7th, 2001)). From the above, based on "severe irritation" in rats, it was classified in Category 2A. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2011), PATTY (6th, 2012), HSDB (Access on September 2014)), As for in vitro, it was negative in a bacterial reverse mutation test (SIDS (2011), PATTY (6th, 2012), HSDB (Access on September 2014)). From the above, it was classified as "Classification not possible." |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
Fertility was affected (a reduction in the number of dams which delivered), however, no embryo-fetal toxicity was observed at doses where parental toxicity (a reduction in activity, partially closed eyes, reddish tear, nasal discharge, a reduction in feed consumption and body weight) was observed, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) by the inhalation route with rats (PATTY (6th, 2012), SIDS (2011)). Therefore, it was classified in Category 2. |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
This substance produced respiratory irritation (ACGIH (7th, 2001), PATTY (6th, 2012)). In humans, there are reports of headache, vertigo and difficulty in breathing, and in experimental animals, narcosis, coordination ataxia and loss of reflexes were seen (ACGIH (7th, 2001), PATTY (6th, 2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In humans, there is no knowledge on repeated exposures. As for experimental animals, there are descriptions that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422; GLP-compliant)in which rats were repeatedly exposed to the vapor of this substance for 49 days for males and for 36-49 days until day 4 of lactation for females, including 14 days before mating for males and females that exposure-dependent histopathological changes in the respiratory and olfactory epithelium of the nasal passages were observed (SIDS (2011)), and that irritating effects on the respiratory organs as histological change, and nasal exudate, irritant changes in the respiratory and olfactory epithelium, chronic inflammation or focal metaplasia of the epithelium as the inflammatory change were seen (PATTY (6th, 2012)). There is a report that the LOAEL was 31 ppm (124 mg/m3, converted guidance value: 0.068 mg/L/6 hours (Category 1)), where exudate in the olfactory epithelium was the only finding (SIDS (2011)). Decreased body weight gain was observed as systemic effects in this test, but no findings suggesting target organs other than the respiratory organs were seen (SIDS (2011), PATTY (6th, 2012)). There were no other reliable data available for classification. Therefore, from the results of the inhalation exposure test with rats, it was classified in Category 1 (respiratory organs). Besides, the findings in humans in ACGIH (7th, 2001) were described as evidence of the classification in the previous classification, however, it was judged that it could not be used for this classification because it is a description of the effects of acute exposure. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
It was classified in Category 3 from 96-hour LC50 = 71 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2011). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" from a low bioconcentration estimate (LogPow = 1.37 (PHYSPROP Database, 2009)) although it is rapidly degradable (a 14-day degradation rate by BOD = 77.2% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and it was classified in Category 3 in acute toxicity. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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