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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10025-87-3
Chemical Name	Phosphoryl chloride
Substance ID	H26-B-110, R-051
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (1997)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (1997)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (1997)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It reacts violently with water to produce heat and decomposition products including hydrochloric acid and phosphoric acid, generating fire and explosion hazard (ICSC (1997)), but flammable gases are not emitted.
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an inorganic compound containing halogen and oxygen, but the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P361+P364 P264 P270 P321 P330 P405 P501	There are 2 reports of LD50 values of 36 mg/kg and 380 mg/kg for rats (SIDS (2006)). They correspond to Category 2 and Category 4, respectively, however, it was classified in Category 2 to which the smallest value among LD50 values corresponds. A new information source (SIDS (2006)) was added, and the category was revised.
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P280 P312 P321 P361 P364 P405 P501	There are reports of LD50 values of 1,000 mg/kg< LD50 <1,580 mg/kg (male) and 631 mg/kg< LD50 <1,000 mg/kg (female) for rabbits (SIDS (2006)). They correspond to Category 3 and Category 4, respectively, however, it was classified in Category 3 to which the smallest value among LD50 values corresponds. A new information source (SIDS (2006)) was added, and the category was revised.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a report of an LC50 value (4 hours) of 48.4 ppm for rats (SIDS (2006), ACGIH (7th, 2001)), it was classified in Category 1. Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (52,320 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There are multiple results that it was corrosive in skin irritation tests with rabbits (SIDS (2006)), and this substance was judged as a corrosive substance in SIDS (2006). In addition, there is a description that it may cause intense irritation also in humans (ACGIH (7th, 2001)). From the above results, it was classified in Category 1. Besides, this substance was classified in "C; R35" in EU DSD classification and in "Skin Corr. 1B H314" in EU CLP classification.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There are multiple reports that severe damages were observed in eye irritation tests with rabbits (SIDS (2006)). In addition, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are reports that no sensitization was observed in a maximization test with guinea pigs and a mouse ear swelling test (SIDS (2006)), however, details such as test conditions were unknown, therefore, the data were judged to be insufficient for use in classification.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in bacterial reverse mutation tests (SIDS (2006)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is severely irritating to the respiratory tract (SIDS (2006), ACGIH (7th, 2001)). In humans, headache, dizziness, nausea, vomiting, chest pain, cough, wheezing, dyspnea, bronchitis, bronchopneumonia and pulmonary edema by the inhalation exposure, and stomach pain, vomiting, perforations of the esophagus and stomach and prostration by the oral exposure were reported (SIDS (2006), PATTY (6th, 2012), ACGIH (7th, 2001), HSDB (Access on September 2014)). As for experimental animals, salivation, lateral position, disturbance of movement co-ordination, labored breathing, convulsions and respiratory impairment by the inhalation exposure of rats, and disturbance of movement co-ordination, weakness and reduced respiratory frequency by the oral administration to rats were reported (SIDS (2006)). Effects by inhalation in rats were observed within the dose range corresponding to Category 1, and effects in rats orally dosed were observed within the dose range corresponding to Category 2. From the above, it was classified in Category 1 (central nervous system, respiratory organs). Besides, degeneration of the nerve cells of rats described in the previous classification was not adopted because it was described as that in a repeated dose study.
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, respiratory organs, kidney)	Danger	H372	P260 P264 P270 P314 P501	There are descriptions that chronic inhalation effects by the occupational exposure in humans included the instances of nephritis (ACGIH (7th, 2001), PATTY (6th, 2012)) in addition to effects on the respiratory organs (cough, rhinitis, bronchitis, bronchopneumonia, pulmonary edema, etc.) and effects on the central nervous system (headache, dizziness, sleeping disorders, weakness, nausea, etc.) (SIDS (2006), ACGIH (7th, 2001)). As for experimental animals, there is a description that by the inhalation exposure to this substance (estimated as a vapour) with rats for 4 months, effects on the kidney (increased kidney weight, fatty degeneration) were observed in addition to irritating effects on the respiratory system (rhinitis, bronchitis) at concentrations of 0.48-1.34 mg/m3 (converted guidance value: 0.00032-0.00089 mg/L/6 hours) (SIDS (2006)). From the above, it was classified in Category 1 (central nervous system, respiratory organs, kidney).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 72-hour ErC50 = 32.12 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 12.5 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006) although environmental dynamics of the inorganic compound are unknown. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" from 48-hour EC50 > 100 mg/L for crustacea (Daphnia magna) (a test with pH adjusted solutions, SIDS, 2006) although environmental dynamics of the inorganic compound are unknown. This substance decomposes readily in water to produce hydrochloric acid and phosphoric acid, decreasing pH, and it is concluded that the decreased pH causes the effetcs on aquatic organisms (SIDS, 2006). On top of that, based on the expert judgment, it was classified as "Not classified" in chronic toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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