GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 506-77-4
Chemical Name Cyanogen chloride
Substance ID H26-B-109, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Classification not possible
-
-
- - There are data of an upper explosion limit: 23.5% (Matheson (2001)) but no data of a lower explosion limit. Because it is not possible to select Category 1 or Category 2, the classification is not possible. Besides, it is classified in Division 2.3, Subsidiary Risk 8 (UN1589) in UNRTDG.
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not classified
-
-
- - Because there are data of an upper explosion limit: 23.5% (Matheson (2001)), and the substance is combustible, it was classified as "Not classified."
5 Gases under pressure Liquefied gas


Warning
H280 P410+P403 From a critical temperature (175 deg C (GESTIS (Access on September 2014))) above 65 deg C, it was classifies as liquefied gas (low pressure liquefied gas).
6 Flammable liquids Not applicable
-
-
- - Gas (GHS definition)
7 Flammable solids Not applicable
-
-
- - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - Gas (GHS definition)
9 Pyrophoric liquids Not applicable
-
-
- - Gas (GHS definition)
10 Pyrophoric solids Not applicable
-
-
- - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable
-
-
- - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - Gas (GHS definition)
13 Oxidizing liquids Not applicable
-
-
- - Gas (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - Gas (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Gas (GHS definition)
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to gas substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Dermal) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Inhalation: Gases) Category 1


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
There is a report that the lethal concentration for mice (3-minute exposure) was about 400 ppm (1.0 mg/L) (converted 4-hour equivalent value: 89.4 ppm) and exposure to humans at 48 ppm for 30 minutes (converted 4-hour equivalent value: 17 ppm) was fatal (ACGIH (7th, 2014)). Based on these findings, the LC50 value (4 hours) is estimated to be <100 ppm. therefore, it was classified in Category 1. Besides, the reference value in units of ppm was applied as a vapour without a mist because the lethal concentration was lower than 90% of the saturated vapor concentration (19,615,005 ppm).
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable
-
-
- - Gas (GHS definition)
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
Although there is no concrete information, there is a description that the vapor of this substance may damage the skin (HSDB (Access on September 2014)). The subsidiary hazard for the Transport of Dangerous Goods of this substance is 8. From the above, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Although it is not concrete information, there are descriptions that the vapor of this substance is severely irritating to the eyes in humans (ACGIH (7th, 2001)), and that the vapor of this substance damages the skin (HSDB (Access on September 2014)). In addition, there is a description that cyanides cause mild conjunctival edema, lacrimation and conjunctival hyperemia, etc (CICAD 61 (2004)). From the above results, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There is no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test (NTP DB (Access on October 2014)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory organs, cardiovascular system, muscular system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
This substance causes marked irritation of the respiratory tract (ACGIH (7th, 2014), ATSDR (2006), PATTY (6th, 2012)). Multiple poisoning cases including suicide and worker exposure were reported in humans. Most of these reports related to hydrogen cyanide and potassium cyanide, however, common effects were assumed for inorganic cyanide compounds (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 61 (2004), ACGIH (7th, 2014), ATSDR (2006)). Regardless of the exposure route, acute symptoms included effects on the central nervous system, respiratory organs, cardiovascular system and muscular system, such as headache, vertigo, vomiting, gastric erosions, lack of motor coordination, numbness in limbs, mydriasis, deep reflection loss, stupor, convulsions, tonic-clonic convulsions, coma, irregular respiration, respiratory distress, dyspnea, palpitation, hypotension, weak pulse, cardiac arrhythmia, enlarged heart, tracheal congestion with hemorrhage, cerebral edema, pulmonary edema, muscular rigidity, rhabdomyolysis, and skeletal muscle injury (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 61 (2004), ATSDR (2006)).
As for experimental animals, as in humans, there is little knowledge about this substance. Motor incoordination, dyspnea, rapid breathing, tremors, convulsions, coma, decreased respiratory rate, cardiac arrhythmia, hemorrhagic exudate from the bronchi and trachea, and pulmonary edema, etc. were reported by the inhalation or oral exposure to inorganic cyanide compounds (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 61 (2004), ACGIH (7th, 2014), ATSDR (2006)), and these findings were also observed in humans. Besides, effects of inhalation exposure were observed within the dose range corresponding to Category 1.
From the above, inferred from inorganic cyanide data, this substance was considered to affect the central nervous system, respiratory organs, cardiovascular system and muscular system, therefore, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, muscular system).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, respiratory organs, haemal system)


Danger
H372 P260
P264
P270
P314
P501
There are descriptions that muscular weakness and lung congestion in addition to skin and eye irritation were observed in a person exposed occupationally to this substance (concentration unknown) for 8 months (ACGIH (7th, 2014)), and that the toxic effects of this substance in experimental animals were pulmonary edema and the interference of cellular metabolism caused by cyanide ion (ACGIH (7th, 2014)), therefore, at least the respiratory organ was considered to be a target organ. However, there were no other findings regarding effects of repeated exposure to this substance in either humans or experimental animals.
On the other hand, as for hazardous findings by repeated exposure to inorganic cyanides in humans, in a group of workers exposed to cyanide from a plating bath containing 3% each of sodium cyanide and copper cyanide, central nervous symptoms and respiratory symptoms such as headache, giddiness, changes in taste and smell, vomiting, effort dyspnea, precordial pain occurred more frequently than in the control group, and increases in hemoglobin, cyanomethemoglobin and lymphocytes were observed (CICAD 61 (2004)). In a group of workers exposed to cyanide at plants producing sodium cyanide, potassium cyanide, and copper cyanide, increased trends in hemoglobin and lymphocytes were observed compared to the control group (CICAD 61 (2004)). From the above, effects mainly due to cyanide poisoning by the mixed exposure to inorganic cyanides were suggested to be effects on the central nervous system, respiratory organs and blood system in humans.
From the above, effects on the respiratory organ were reported by exposure to this substance, and the central nervous system, respiratory organs and hemal system were suggested as target organs by repeated exposure to inorganic cyanide compounds, and it was classified in Category 1 (central nervous system, respiratory organs, blood system).
Besides, refer to Copper Cyanide (I) (CAS RN: 544-92-3) for the classification results of related substances.
10 Aspiration hazard Not applicable
-
-
- - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information