Item | Information |
---|---|
CAS RN | 506-77-4 |
Chemical Name | Cyanogen chloride |
Substance ID | H26-B-109, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | Gas (GHS definition) |
2 | Flammable gases (including chemically unstable gases) | Classification not possible |
- |
- | - | There are data of an upper explosion limit: 23.5% (Matheson (2001)) but no data of a lower explosion limit. Because it is not possible to select Category 1 or Category 2, the classification is not possible. Besides, it is classified in Division 2.3, Subsidiary Risk 8 (UN1589) in UNRTDG. |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not classified |
- |
- | - | Because there are data of an upper explosion limit: 23.5% (Matheson (2001)), and the substance is combustible, it was classified as "Not classified." |
5 | Gases under pressure | Liquefied gas |
Warning |
H280 | P410+P403 | From a critical temperature (175 deg C (GESTIS (Access on September 2014))) above 65 deg C, it was classifies as liquefied gas (low pressure liquefied gas). |
6 | Flammable liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
7 | Flammable solids | Not applicable |
- |
- | - | Gas (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Gas (GHS definition) |
11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Gas (GHS definition) |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | Gas (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Gas (GHS definition) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | Gas (GHS definition) |
1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | Gas (GHS definition) |
1 | Acute toxicity (Inhalation: Gases) | Category 1 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
There is a report that the lethal concentration for mice (3-minute exposure) was about 400 ppm (1.0 mg/L) (converted 4-hour equivalent value: 89.4 ppm) and exposure to humans at 48 ppm for 30 minutes (converted 4-hour equivalent value: 17 ppm) was fatal (ACGIH (7th, 2014)). Based on these findings, the LC50 value (4 hours) is estimated to be <100 ppm. therefore, it was classified in Category 1. Besides, the reference value in units of ppm was applied as a vapour without a mist because the lethal concentration was lower than 90% of the saturated vapor concentration (19,615,005 ppm). |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Gas (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | Gas (GHS definition) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Although there is no concrete information, there is a description that the vapor of this substance may damage the skin (HSDB (Access on September 2014)). The subsidiary hazard for the Transport of Dangerous Goods of this substance is 8. From the above, it was classified in Category 1. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
Although it is not concrete information, there are descriptions that the vapor of this substance is severely irritating to the eyes in humans (ACGIH (7th, 2001)), and that the vapor of this substance damages the skin (HSDB (Access on September 2014)). In addition, there is a description that cyanides cause mild conjunctival edema, lacrimation and conjunctival hyperemia, etc (CICAD 61 (2004)). From the above results, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test (NTP DB (Access on October 2014)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, cardiovascular system, muscular system) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
This substance causes marked irritation of the respiratory tract (ACGIH (7th, 2014), ATSDR (2006), PATTY (6th, 2012)). Multiple poisoning cases including suicide and worker exposure were reported in humans. Most of these reports related to hydrogen cyanide and potassium cyanide, however, common effects were assumed for inorganic cyanide compounds (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 61 (2004), ACGIH (7th, 2014), ATSDR (2006)). Regardless of the exposure route, acute symptoms included effects on the central nervous system, respiratory organs, cardiovascular system and muscular system, such as headache, vertigo, vomiting, gastric erosions, lack of motor coordination, numbness in limbs, mydriasis, deep reflection loss, stupor, convulsions, tonic-clonic convulsions, coma, irregular respiration, respiratory distress, dyspnea, palpitation, hypotension, weak pulse, cardiac arrhythmia, enlarged heart, tracheal congestion with hemorrhage, cerebral edema, pulmonary edema, muscular rigidity, rhabdomyolysis, and skeletal muscle injury (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 61 (2004), ATSDR (2006)). As for experimental animals, as in humans, there is little knowledge about this substance. Motor incoordination, dyspnea, rapid breathing, tremors, convulsions, coma, decreased respiratory rate, cardiac arrhythmia, hemorrhagic exudate from the bronchi and trachea, and pulmonary edema, etc. were reported by the inhalation or oral exposure to inorganic cyanide compounds (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 61 (2004), ACGIH (7th, 2014), ATSDR (2006)), and these findings were also observed in humans. Besides, effects of inhalation exposure were observed within the dose range corresponding to Category 1. From the above, inferred from inorganic cyanide data, this substance was considered to affect the central nervous system, respiratory organs, cardiovascular system and muscular system, therefore, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, muscular system). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, respiratory organs, haemal system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There are descriptions that muscular weakness and lung congestion in addition to skin and eye irritation were observed in a person exposed occupationally to this substance (concentration unknown) for 8 months (ACGIH (7th, 2014)), and that the toxic effects of this substance in experimental animals were pulmonary edema and the interference of cellular metabolism caused by cyanide ion (ACGIH (7th, 2014)), therefore, at least the respiratory organ was considered to be a target organ. However, there were no other findings regarding effects of repeated exposure to this substance in either humans or experimental animals. On the other hand, as for hazardous findings by repeated exposure to inorganic cyanides in humans, in a group of workers exposed to cyanide from a plating bath containing 3% each of sodium cyanide and copper cyanide, central nervous symptoms and respiratory symptoms such as headache, giddiness, changes in taste and smell, vomiting, effort dyspnea, precordial pain occurred more frequently than in the control group, and increases in hemoglobin, cyanomethemoglobin and lymphocytes were observed (CICAD 61 (2004)). In a group of workers exposed to cyanide at plants producing sodium cyanide, potassium cyanide, and copper cyanide, increased trends in hemoglobin and lymphocytes were observed compared to the control group (CICAD 61 (2004)). From the above, effects mainly due to cyanide poisoning by the mixed exposure to inorganic cyanides were suggested to be effects on the central nervous system, respiratory organs and blood system in humans. From the above, effects on the respiratory organ were reported by exposure to this substance, and the central nervous system, respiratory organs and hemal system were suggested as target organs by repeated exposure to inorganic cyanide compounds, and it was classified in Category 1 (central nervous system, respiratory organs, blood system). Besides, refer to Copper Cyanide (I) (CAS RN: 544-92-3) for the classification results of related substances. |
10 | Aspiration hazard | Not applicable |
- |
- | - | Gas (GHS definition) |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|