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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	110-43-0
Chemical Name	Methyl n-pentyl ketone (2-Heptanone)
Substance ID	H26-B-101, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 39 deg C (closed cup) (HSDB (Access on September 2014)). Besides, it is classified in Class 3, PG III (UN1110) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 393 deg C (ICSC (1996)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P362+P364 P264 P270 P330 P501	There are three reports of LD50 values of 1,600 mg/kg (PATTY (6th, 2012)), 1,670 mg/kg (PATTY (6th, 2012), ACGIH (7th, 2001)) and 2,407 mg/kg (PATTY (6th, 2012)) for rats. Since 2 values correspond to Category 4 and 1 value corresponds to "Not classified," it was classified in Category 4 with a larger number of values.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of 12.6 mL/kg (10,300 mg/kg) (PATTY (6th, 2012)) for rabbits, it was classified as "Not classified."
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that as a result of application of this substance to rabbits for 24 hours, moderate irritation was observed (ACGIH (7th, 2001), PATTY (6th, 2012)), but it was not used for classification since it is the result of a 24-hour application.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There is a report that in a test in which this substance was applied to the eyes of rabbits, mild irritation was observed (PATTY (6th, 2012)). In addition, in another test with rabbits, no changes in the eyes corresponding to the criteria for irritation were observed (ECETOC TR48 (1992)). From the above, based on the description of "slight irritation," it was classified in Category 2B.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that in a skin sensitization study in which a 4% solution of this substance was applied to 26 volunteers, no positive reactions were observed (PATTY (6th, 2012)), but since the details were unknown and there was no other information from experimental animals, it was classified as "Classification not possible."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test (details unknown) (PATTY (6th, 2012), HSDB (Access on September 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	There is a report that in a reproduction/developmental toxicity screening test with rats by the inhalation route, although a transient decrease in food consumption and a transient bodyweight change were seen, no reproductive toxicity and developmental toxicity were (PATTY (6th, 2012)). Classification was not possible because it is a screening test.
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance causes respiratory tract irritation and narcotic effects in humans (ACGIH (7th, 2001), PATTY (6th, 2012)). As for experimental animals, there are reports of piloerection, vasodilation, hyperpnea, ataxia, prostration and dyspnea by inhalation exposure with rats at 830-2,000 ppm (3.87-9.34 mg/L) (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on September 2014)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Although there was no finding of adverse effects by exposure to this substance alone in humans, there is a description that in a cross-sectional epidemiological study designed to assess cognitive performance and mental health among workers in paint manufacturing factories exposed to solvents containing low concentrations of this substance, no adverse effects were observed (PATTY (6th, 2012)). As for experimental animals, in a 13-week study with rats dosed by gavage, slight increases in liver and kidney weights with no histopathological changes were seen at up to 500 mg/kg (PATTY (6th, 2012)). In the inhalation route, there is a description that in a test in which rats and monkeys were exposed to the vapour of this substance at high concentrations up to 1,025 ppm (4.78 mg/L/6 hours: 1 ppm=4.66 mg/m3 (ACGIH (7th, 2001))) for 9 months, no abnormalities in pulmonary function, electrocardiographic, or clinical chemical parameters were observed in any species, and no toxic effects including neurotoxic effects (clinical signs and nerve conduction velocity) were observed (PATTY (6th, 2012), ACGIH (7th, 2001)). As described above in experimental animals, no toxicological findings possible to identify target organs at doses within the guidance value range were confirmed as adverse findings through the two routes, but findings in humans were very limited, therefore, it was considered difficult to classify as "Not classified" like in the previous classification, and it was classified as "Classification not possible."
10	Aspiration hazard	Classification not possible	- -	-	-	This substance is a ketone composed of carbon atoms not exceeding 13 and its kinematic viscosity is 0.954 mm2/sec (30 deg C, calculated value by CERI), and corresponds to Category 2 in UN Classification Standards, therefore, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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