GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 19624-22-7
Chemical Name Pentaborane
Substance ID H26-B-094, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 3 based on a flash point of 30 deg C (Closed cup) (ICSC (1998)).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Category 1


Danger
H250 P302+P334
P370+P378
P210
P222
P280
P422
It is classified in Division 4.2, Subsidiary Risk 6.1, PG I (UN1380) in UNRTDG.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Not applicable
-
-
- - It was classified in pyrophoric liquids.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible
-
-
- - No data available.
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 1


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on a report of an LC50 value (4 hours) of 6 ppm for rats (ACGIH (7th, 2001)), it was classified in Category 1. Besides, since the LC50 value was lower than 90% of the saturated vapour concentration (225,074 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
Although there were no data on experimental animal tests, based on a description that contact can severely irritate and burn the skin (HSFS (2000)), it was classified in Category 2.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There are descriptions that this substance is irritating to the eyes (HSDB (Access on September 2014)), and that vapour exposure with humans caused necrotic changes, serious kerato-conjunctivitis with ulceration and corneal opacification (HSDB (Access on September 2014)). From the above result, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, liver), Category 3 (respiratory tract irritation, narcotic effects)



Danger
Warning
H370
H335
H336
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
This substance is irritating to the respiratory tract (ACGIH (7th, 2001), HSDB (Access on September 2014)). As for humans, there are reports of multiple accidents and cases. By inhalation exposure at lower concentrations, nausea, drowsiness, behavioral changes including loss of recent memory and poor judgment, visual disturbances were observed, and by inhalation exposure at higher concentrations, effects on the central nervous system such as headache, dizziness, nervous excitation, ataxia, muscular pains, tremors, clonic convulsions, convulsions, opisthotonic convulsions, incoordination, disorientation, coma and irreversible central nervous system damage were consistently observed (ACGIH (7th, 2001), HSDB (Access on September 2014)). In 3 cases of accidental poisoning due to this substance, it was described that in addition to central nervous system symptoms, elevation in serum transaminase (AST, ALT) activity suggesting liver damage was observed (PATTY (6th, 2012)).
As for experimental animals, central nervous system change was observed in mice by inhalation exposure at 342 mg/m3 (PATTY (6th, 2012)).
From the above, it was classified in Category 1 (central nervous system, liver), Category 3 (respiratory tract irritation, narcotic effects).
Besides, although the liver was not adopted in the previous classification, it was added in this classification because liver damage was described as the acute toxic finding in humans by acute exposure.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system)


Danger
H372 P260
P264
P270
P314
P501
There was no clear finding on humans by repeated exposure. As for experimental animals, there are descriptions that hyperexcitability and tremors were observed when rats were exposed by inhalation at 3 ppm (7.74 mg/m3) for 4 weeks (ACGIH (7th, 2001)), and that symptoms via the central nervous system such as apathy, incoordination, hind limb immobility and muscle tremors were observed when rats, rabbits, dogs and monkeys inhaled 0.2 ppm (0.516 mg/m3) of the vapour of this substance for 6 months (PATTY (6th, 2012), ACGIH (7th, 2001)). In all tests, central nervous system symptoms appeared within the concentration range for Category 1. From the above, it was classified in Category 1 (central nervous system).
Besides, in the previous classification, because it was described that hepatic effects on humans were observed in an information source not listed on the information source lists on the GHS classification guidance for the Japanese government (HSFS (2000)), the "liver" was adopted as a target organ. In PATTY (6th, 2012) which is the information source of List 1, it was described that elevation in serum transaminase (AST, ALT) activity suggesting liver damage was observed in 3 cases exposed to this substance. However, as a result of confirming the effects on the hepatic function in these three cases in the original report (Yarbrough, B. E. et al. (1985-1986)), it was found that all were delayed findings due to acute exposure poisoning from pentaborane by accident. Therefore, the "liver" was deleted from target organs in this classification.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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