Item | Information |
---|---|
CAS RN | 19624-22-7 |
Chemical Name | Pentaborane |
Substance ID | H26-B-094, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on a flash point of 30 deg C (Closed cup) (ICSC (1998)). |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Category 1 |
Danger |
H250 |
P302+P334
P370+P378 P210 P222 P280 P422 |
It is classified in Division 4.2, Subsidiary Risk 6.1, PG I (UN1380) in UNRTDG. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | It was classified in pyrophoric liquids. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | No data available. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on a report of an LC50 value (4 hours) of 6 ppm for rats (ACGIH (7th, 2001)), it was classified in Category 1. Besides, since the LC50 value was lower than 90% of the saturated vapour concentration (225,074 ppm), the reference value in units of ppm was applied as a vapour without a mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
Although there were no data on experimental animal tests, based on a description that contact can severely irritate and burn the skin (HSFS (2000)), it was classified in Category 2. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There are descriptions that this substance is irritating to the eyes (HSDB (Access on September 2014)), and that vapour exposure with humans caused necrotic changes, serious kerato-conjunctivitis with ulceration and corneal opacification (HSDB (Access on September 2014)). From the above result, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, liver), Category 3 (respiratory tract irritation, narcotic effects) |
Danger Warning |
H370
H335 H336 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is irritating to the respiratory tract (ACGIH (7th, 2001), HSDB (Access on September 2014)). As for humans, there are reports of multiple accidents and cases. By inhalation exposure at lower concentrations, nausea, drowsiness, behavioral changes including loss of recent memory and poor judgment, visual disturbances were observed, and by inhalation exposure at higher concentrations, effects on the central nervous system such as headache, dizziness, nervous excitation, ataxia, muscular pains, tremors, clonic convulsions, convulsions, opisthotonic convulsions, incoordination, disorientation, coma and irreversible central nervous system damage were consistently observed (ACGIH (7th, 2001), HSDB (Access on September 2014)). In 3 cases of accidental poisoning due to this substance, it was described that in addition to central nervous system symptoms, elevation in serum transaminase (AST, ALT) activity suggesting liver damage was observed (PATTY (6th, 2012)). As for experimental animals, central nervous system change was observed in mice by inhalation exposure at 342 mg/m3 (PATTY (6th, 2012)). From the above, it was classified in Category 1 (central nervous system, liver), Category 3 (respiratory tract irritation, narcotic effects). Besides, although the liver was not adopted in the previous classification, it was added in this classification because liver damage was described as the acute toxic finding in humans by acute exposure. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There was no clear finding on humans by repeated exposure. As for experimental animals, there are descriptions that hyperexcitability and tremors were observed when rats were exposed by inhalation at 3 ppm (7.74 mg/m3) for 4 weeks (ACGIH (7th, 2001)), and that symptoms via the central nervous system such as apathy, incoordination, hind limb immobility and muscle tremors were observed when rats, rabbits, dogs and monkeys inhaled 0.2 ppm (0.516 mg/m3) of the vapour of this substance for 6 months (PATTY (6th, 2012), ACGIH (7th, 2001)). In all tests, central nervous system symptoms appeared within the concentration range for Category 1. From the above, it was classified in Category 1 (central nervous system). Besides, in the previous classification, because it was described that hepatic effects on humans were observed in an information source not listed on the information source lists on the GHS classification guidance for the Japanese government (HSFS (2000)), the "liver" was adopted as a target organ. In PATTY (6th, 2012) which is the information source of List 1, it was described that elevation in serum transaminase (AST, ALT) activity suggesting liver damage was observed in 3 cases exposed to this substance. However, as a result of confirming the effects on the hepatic function in these three cases in the original report (Yarbrough, B. E. et al. (1985-1986)), it was found that all were delayed findings due to acute exposure poisoning from pentaborane by accident. Therefore, the "liver" was deleted from target organs in this classification. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|