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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	77-47-4
Chemical Name	Hexachlorocyclopentadiene
Substance ID	H26-B-086, R-036
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (2005)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (2 conjugated unsaturated bonds) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (2005)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2005)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, there is information that it corrodes various metals in presence of moisture (HSDB (Access on August 2014)).

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P362+P364 P264 P270 P330 P501	There were reports of 11 data items of LD50 values of > 50 mg/kg (EU-RAR (2007)), 315 mg/kg (female), 425 mg/kg (male) (EU-RAR (2007), EHC 120 (1991)), 471 mg/kg (ATSDR (1999)), 505 mg/kg (male), 690 mg/kg (female) (EU-RAR (2007), IRIS TR (2001), EHC 120 (1991)), 584 mg/kg (male, female) (EU-RAR (2007), IRIS TR (2001), ATSDR (1999)), 630 mg/kg (ATSDR (1999)), 651 mg/kg (male, female) (EU-RAR (2007), EHC 120 (1991)), 926 mg/kg (male, female) (EHC 120 (1991)), and 1,400 mg/kg (male, female) (EU-RAR (2007)) for rats. It was classified in Category 4 to which the larger number of values (10 data) corresponded.
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P280 P312 P321 P361 P364 P405 P501	There are reports of 5 data items of LD50 values of < 200 mg/kg (male), 340 mg/kg (female) (EU-RAR (2007), EHC 120 (1991)), < 200 mg/kg (EU-RAR (2007)) and 780 mg/kg (EU-RAR (2007), EHC 120 (1991)) for rabbits, and LD50 values of 2,000-3,200 mg/kg (EU-RAR (2007)) for rats. It was classified in Category 3 to which the larger number of values (2 data items) corresponded according to the GHS classification guidance for the Japanese government. Besides, the category could not be specified by two reports with the minimum LD50 value, and the remaining one case corresponded to "Not classified" (Category 5 in UN GHS classification). A new information source (EU-RAR (2007)) was added, and the category was revised.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on reports of LC50 values of 1.6 ppm (male), 3.5 ppm (female) (EU-RAR (2007), ATSDR (1999), EHC 120 (1991)), 3.7 ppm, 3.0 ppm (EU-RAR (2007)), 3.44 ppm, 1.6 ppm (male), and 3.9 ppm (female) (IRIS TR (2001)) for rats, it was classified in Category 1. Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (78.9 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although there was a report of an LC50 value of < 2 mg/L for rats (EU-RAR (2007)), the category could not be specified only with this data. Besides, there is a description that the test was conducted with the mist and the aerosol, and the LC50 value was higher than the saturated vapor concentration (0.88 mg/L), therefore, the reference values as a mist were applied.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a skin irritation test with rabbits, it was found corrosive in tests in which the undiluted liquid or a 10% aqueous solution of this substance was applied (EU-RAR (2007)). In addition, there are reports that it was also found corrosive in a test in which 40-90% aqueous solutions of this substance were applied to guinea pigs (EU-RAR (2007)) and that there was moderate to severe primary irritation on rabbit skin (EHC 120 (1991)). In humans, there is a report that it was irritating to the skin (IRIS (2001), EU-RAR (2007)). From the above, based on the "corrosive" results in rabbits, it was classified in Category 1. Besides, this substance was classified in "C; R34" in the EU DSD classification, in "Skin Corr. 1B H314" in the EU CLP classification. Information was added, and the category was changed.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a report that in an eye irritation test in which 0.1 mL of this substance (unknown concentration) was applied to rabbits, necrosis and blanching were observed and severe irritation was observed (EU-RAR (2007), EHC 120 (1991), ATSDR (1999)). In addition, this substance was classified in Category 1 in the classification for skin corrosion/irritation. From the above results, it was classified in Category 1. Based on additional information in EU-RAR (2007), and Category 1 for skin irritation, the category was changed.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In a skin sensitization test (OECD TG 406) with guinea pigs, the positive rate was 100%, and it was concluded that it was a skin sensitizer (EU-RAR (2007)). In addition, there is a report that in another sensitization test with guinea pigs, sensitization reaction was observed in all treated animals (EHC 120 (1991), EU-RAR (2007)). From the above results, it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse dominant lethal test and a micronucleus test with mouse peripheral blood erythrocytes (EU-RAR (2007), ATSDR (1999), NTP TR437 (1994), EHC 192 (1997), IUCLID (2000), NTP DB (Access on September 2014)). As for in vitro, it was negative in bacterial reverse mutation tests, mammalian cell gene mutation tests, and an unscheduled DNA synthesis test with rat primary cultured hepatocytes, and it was positive in a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells (EU-RAR (2007), ACGIH (7th, 2001), NTP DB (Access on September 2014), IUCLID (2000)).
6	Carcinogenicity	Not classified	- -	-	-	It was classified in A4 by ACGIH (7th, 2001) and as E in 1986 and as NL in 1996 by EPA (IRIS (2001)). In addition, it was evaluated in SIAP (2007) that there was no evidence for carcinogenicity since no carcinogenicity was observed in any of carcinogenicity tests with rats and mice by inhalation exposure for 2 years and so on. From the above, although it corresponds to "Classification not possible" based on the classification by ACGIH and to "Not classified" based on the classification by EPA, by combining with the evaluation that there was no evidence for carcinogenicity since no evidence of carcinogenicity was observed in rats and mice (SIAP (2007)), EPA classification was prioritized, therefore, it was classified as "Not classified." Besides, although it was classified as "Not classified" based on A4 by ACGIH, as E and NL by EPA in the previous classification, according to the revised GHS classification guidance for the Japanese government, it was changed to "Classification not possible" in the case of A4 by ACGIH.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are reports that in teratogenicity tests with rats, mice and rabbits by the oral route (gavage), neither maternal toxicity nor developmental toxicity was observed in rats and mice, and no developmental toxicity was observed even at doses where maternal toxicities were observed in rabbits (EU-RAR (2007), IRIS (2001), ATSDR (1999), NTP TR437 (1994), EHC 120 (1991)). Although it was classified as "Not classified" only based on the information from teratogenicity tests in the previous classification, since there was inadequate information on fertility, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, liver, kidney), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance was irritating to the respiratory tract (ACGIH (7th, 2001), ATSDR (1999), EHC 192 (1997), IRIS Tox. Review (2001), HSDB (Access on August 2014)). Although multiple cases were reported in humans, no data were available for classification. As for experimental animals, by the inhalation exposure with rats, pulmonary abnormalities (red focal or diffuse consolidation), pulmonary hemorrhage at or above 1.4 ppm (0.016 mg/L), infiltration of neutrophils, erythrocytes and fibrin in the necrotic tissue of the bronchial tubes, obliterative bronchitis, bronchiolitis, and connective tissue proliferations at 0.15-78.6 ppm (0.002-0.88 mg/L) were observed, and hyperemia and edema of the lungs were observed at 0.3-66 ppm (0.003-0.74 mg/L) in rats, mice, rabbits and guinea pigs. By oral administration, diarrhea, piloerection, hunched posture, abnormal gait, lethargy, decreased respiration, ptosis and pallor of the extremities were observed at 1,260-2,000 mg/kg in rats and 180-2,100 mg/kg in rabbits, hyperemia and edema of the lungs at 261-1,959 mg/kg in rats and rabbits, necrosis of the liver and kidney, degenerative changes of the liver, and degeneration of the kidney tubules at 401-5,719 mg/kg by dermal application to rabbits were observed. There are descriptions that the effects on the above experimental animals were observed not only in the dead animals but also in the surviving animals. And both effects on the respiratory organs by inhalation and oral exposures, and effects on the liver and kidney by dermal exposure were observed at concentrations within the guidance range of Category 1. In addition, it is described in EHC 192 (1997) and IRIS Tox. Review (2001) that irrespective of the administration route, acute exposure caused toxicities in the lung, liver, and kidney, and pathological changes were observed (EU-RAR (2007), ATSDR (1999), EHC 192 (1997), IRIS TR (2001)). From the above, it was classified in Category 1 (respiratory organs, liver, kidney), category 3 (narcotic effects). Although the liver and kidney were specified to Category 2 in the previous classification, since effects on the liver and kidneys were also observed at concentrations corresponding to Category 1, the category was changed.
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (kidney)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Symptoms of the respiratory organs (cough, symptoms of throat irritation, chest discomfort, difficulty in breathing) in 39 of 145 workers exposed to this substance for 3-15 days at a wastewater treatment plant, and headaches (regarded as a secondary effect by stimulation to such as the respiratory organs) were observed in 22 workers. In addition, although no changes in blood counts were observed in a hematological test, urine samples taken from 6 of the 41 workers were positive for proteinuria (ATSDR (1999), IRIS TR (2001)). As for experimental animals, in NTP studies in which rats and mice were exposed by inhalation for 13 weeks or 2 years, and in a study in which rats were exposed by inhalation for 30 weeks, symptoms of the central nervous system (hypoactivity, lethargy), and the respiratory organs' damage (squamous metaplasia of the nasal cavity or larynx, extensive chronic inflammation, necrotic changes or brown pigmentation from the nasal cavity to the lungs (2-year inhalation exposure studies)) were observed within the concentration range of Category 1 (0.00011-0.0063 mg/L/6 hours) in any studies (EU-RAR (2007), ATSDR (1999), IRIS Tox. Review (2001)). Among these studies, there is a description that in 30-week inhalation exposure studies with rats, effects on the hemal system (increases in erythrocyte counts, hemoglobin concentration, hematocrit value and neutrophil ratio, etc. (males only)), and degenerative changes in the liver and kidneys were observed within the concentration range of Category 1 (EU-RAR (2007), ATSDR (1999), IRIS TR (2001)). However, the results from the other inhalation studies showed that effects were limited to the local areas of the respiratory organs. By the oral route, in studies in which this substance was administered by gavage to rats or mice for 13 weeks, nephropathy (proximal tubular dilation, cytoplasmic vacuolization or cytomegaly of the tubular epithelial cells, karyomegaly or anisokaryosis) was observed in both rats and mice within the concentration range of Category 2 (38-75 mg/kg/day). In addition, from lower doses, proliferative and inflammatory changes considered to be due to irritation of the forestomach were observed in both rats and mice (EU-RAR (2007), ATSDR (1999), IRIS TR (2001)). From the above, based on the findings in humans and experimental animals, it was classified in Category 1 (respiratory organs), Category 2 (kidney).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 7 microg/L for crustacea (Mysidopsis bahia) and 96-hour LC50 = 7 microg/L for fish (Pimephales promelas) (both EU-RAR, 2007, EHC 120, 1991).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, not rapidly degradable (BIOWIN), then it is classified in Category 1 from 28-day NOEC = 0.3 microg/L for crustacea (Mysidopsis bahia) (EU-RAR, 2007). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 96-hour ErC50 = 190 microg/L for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2007). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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