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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	75-26-3
Chemical Name	2-Bromopropane
Substance ID	H26-B-085, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of -20 deg C (closed cup) and a boiling point of 59 deg C (GESTIS (Access on September 2014)). Besides, it is classified in Class 3, PG II-III (UN2344) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic substances containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	Based on a reported 4-hour LC50 value of 31,171 ppm for mice (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005) and OEL Documentations (Japan Society For Occupational Health (JSOH), 1999)), it was classified as "Not classified." Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (284,211 ppm), the reference value in units of ppm was applied as a vapor without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a reported primary irritation score of 1.44 in a skin irritation test with rabbits (ECETOC TR 66 (1992)), this substance was classified as "Not classified." Based on the irritation score, the classification was changed.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Although slight redness and conjunctival chemosis were observed 24 hours after application in a rabbit eye irritation test, these symptoms disappeared after 72 hours (ECETOC TR48 (1992)). Based on these findings, this substance was classified in Category 2B. Since information of ECETOC TR48 (1992) was added, the classification was changed.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a micronucleus test using rat bone marrow cells was negative (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), OEL Documentations (Japan Society For Occupational Health (JSOH), 1999), HSDB (Access on August 2014)). As for in vitro, a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells were negative (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), OEL Documentations (Japan Society For Occupational Health (JSOH), 1999), NTP DB (Access on September 2014) and HSDB (Access on August 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There is a report that clear effects on genetic organs such as decreased sperm counts and amenorrhea were observed in human exposure cases (for details, refer to Specific target organ toxicity - Repeated exposure.) (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), OEL Documentations (Japan Society For Occupational Health (JSOH), 1999)). Because ovarian and testicular toxicities are reported in cumulative case studies in humans, and ovarian and testicular damages were proven in experimental animal tests, this substance was classified in reproductive toxicants Group 1 in the Recommendation of Occupational Exposure Limits (2014) (Tentative Documents for Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013) and Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2014)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data are available in humans and experimental animals. Besides, although it is described in the previous classification that "there is a description that no toxic effects were observed in mice by high dose exposure in Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)," no concrete information is reported and therefore this data were not adopted. Consequently, classification was not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Category 1 (haemal system, testis, ovary)	Danger	H372	P260 P264 P270 P314 P501	Since this substance has been used as a cleaning solvent as an alternative to chlorofluorocarbons in electronic component manufacturing factories in Korea and unusually many amenorrhea cases in female workers were reported, health hazard surveys were conducted. As a result, amenorrhea in 16 out of 25 female workers and complication of pancytopenia in 8 of them were reported. Six out of 8 male workers showed a decrease in sperm counts or azoospermia, and pancytopenia was also found in 1 of them. In a follow-up survey of the 16 amenorrhea cases, the symptom persisted after 2 years in 14 cases, and commonly in ovarian biopsy cases (4 cases), follicles in each developmental stage were not detected, and atrophy and a decreased number of primordial follicles and fibrosis of the cortex were observed (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2009), OEL Documentations (Japan Society For Occupational Health (JSOH), 1999)). Besides, although severe hematopoietic disorders and adverse effects on genetic organs at 0-81 mg/m3 of individual exposure levels were not observed in a survey in workers at manufacturing factories of this substance in China, a significant correlation between anaemia and exposure concentrations (21-43 mg/m3) was observed in women with normal menstruation (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2009), OEL Documentations (Japan Society For Occupational Health (JSOH), 1999)). In experimental animals, hematotoxicities (decreases in numbers of erythrocytes, leukocytes, and platelets and hematocrit value, and finding of bone marrow), decreased testis weight, decreases in sperm counts and active sperm counts and an increased frequency of sperm morphological abnormalities were observed in a 9-week inhalation exposure study with male rats (assumed as a vapor) exceeding the range of Category 2 (1,510 mg/m3: converted guidance value: 1.39 mg/L/6 hours) (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2009), OEL Documentations (Japan Society For Occupational Health (JSOH), 1999)). On the other hand, in 3- or 9-week inhalation exposure studies with female rats, decreases in numbers of primordial follicles and follicles in the developmental stage in the ovary, and sexual cycle extension were observed at concentrations corresponding to Category 2 (1,030 mg/m3 (3 weeks) or 500 mg/m3 (9 weeks): converted guidance value: 0.32-0.45 mg/L/6 hours). At higher concentrations, an increase in the number of atretic follicles and a decrease in the number of corpora lutea were observed (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2009)). Consequently, toxicological effects on the haemal system, testis and ovary in experimental animals were also confirmed in experimental animals. From the above, this substance was classified in Category 1 (haemal system, testis, ovary).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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