NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	513-77-9
Chemical Name	Barium carbonate
Substance ID	H26-B-077, R-031
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2006)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2006)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2006)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility: 0.002 g/100 mL (20 deg C) (ICSC (2006)) were obtained, it is estimated that it does not react vigorously in contact with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P361+P364 P264 P270 P321 P330 P405 P501	In addition to 3 reports of LD50 values for rats of 418 mg/kg (SIDS (2006), EHC 107 (1990)), 800 mg/kg (EHC 107 (1990)) and 118-800 mg/kg (CICAD 33 (2001)), there is a report of the lowest oral lethal dose in humans of 57 mg/kg (CICAD 33 (2001)). Based on the data in humans, it was classified in Category 3. Instead of a low priority information source (RTECS (2004)), new information sources (SIDS (2006), CICAD 33 (2001)) were added, and the category was revised.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" since barium and its soluble compounds are classified in A4 by ACGIH (7th, 2001).
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. In the previous classification, on the basis that effects on spermatogenesis/oogenesis and on other effects on testis/ovary were observed by inhalation administration to male and female rats (EHC 107 (1990), CICAD 33 (2001)), and that lethal toxicity in fetuses was observed by oral administration to pregnant rats (EHC 107 (1990)), it was classified in Category 2. However, regarding "Tarasenko, NY, Pronin, OA, and Silayev, AA (1977) Barium compounds as industrial poisons (an experimental study), J. Hyg. Epidemiol. Microbiol. Immunol., 21, 361-373" which is the original source of these data, it is stated in ATSDR (2007) that since the study design and reporting were insufficient, and the incidence data or statistical analysis were not described in the published literature, it was not possible to properly evaluate the study results. In addition, SIDS (2006) also did not use these data for evaluation because the reliability could not be evaluated. Therefore, in reviewing the classification, these data were not used for the classification as were considered unreliable.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, cardiovascular system, muscular system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance is irritating to the respiratory tract. In humans there are multiple case reports, in which vomiting, intense abdominal pain, gastrointestinal tract disorders with diarrhea, arrhythmia, elevated blood pressure, loss of tendon reflexes, mydriasis and drowsiness were observed in common with accidental cases, suicide cases and exposure of workers by oral ingestion. Muscle weakness and paralysis of the limbs and necks were reported on acute inhalation of workers to the dust. In addition, it strongly stimulated the striated muscle, cardiac muscle and smooth muscle, and neuromuscular blockade due to a decrease in serum potassium to cause muscle weakness. In multiple cases, high doses caused significant effects on the beating and rhythm of the heart, and ventricular tachycardia, impaired cardiac automaticity, ventricular fibrillation and cardiac arrest occurred. In the intentional or accidental oral ingestion, gastrointestinal disorders (vomiting, diarrhea, abdominal pain), hypokalemia, hypertension, arrhythmia, muscle weakness, skeletal muscle paralysis, flaccid paralysis, and paresthesia were reported (SIDS (2006), ACGIH (7th, 2001), ATSDR (2007), CICAD 33 (2001), EHC 107 (1990), HSDB (Access on August 2014)). In experimental animals, by oral administration (concentration, etc. not described), salivation, nausea, diarrhea, tachycardia, hypokalemia, hypotension, spasms, skeletal muscle relaxation paralysis, respiratory muscle paralysis, and ventricular fibrillation were reported (SIDS (2006), ATSDR (2007), EHC 107 (1990)). From the above, it was classified in Category 1 (nervous system, cardiovascular system, muscular system), Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Category 1 (cardiovascular system, nervous system, muscular system, kidney)	Danger	H372	P260 P264 P270 P314 P501	There is a description that elevated blood pressure in 3 out of 12 workers chronically exposed to the dust of this substance and abnormalities on their electrocardiograms were observed in 2. However, since comparison with the incidence in an unexposed population was not possible, it was not possible to clarify the relationship between exposure to this substance and the increased incidence of cardiovascular disorders (ATSDR (2007)). In addition, while there are two reports of development of pneumonoconiosis in workers chronically exposed to the dust of barium sulfate, there is one report that in workers exposed to this substance, no respiratory symptoms due to barium exposure and no abnormalities in the lung on the X-ray examination were observed (ATSDR (2007)). In experimental animals, there are reports that in studies in which rats were exposed by inhalation to the dust of this substance for 1 or 4 months, at a dose corresponding to Category 1 (converted guidance value: 0.0035 mg/L/6 hours), effects on the respiratory organs, etc. were observed. However, in these studies, since the test items are limited, and descriptions are inadequate, this test is also considered to have an uncertain reliability (SIDS (2006)), and it was considered insufficient data for classification. Therefore, the target organ cannot be identified by the inhalation route. On the other hand, since there is a description that this substance is an acid-soluble barium compound and is absorbed through the gastrointestinal tract after oral ingestion (ATSDR (2007)), it is considered that barium carbonate may cause target organ toxicity similar to that of water-soluble barium chloride (CAS RN 10361-37-2) by the oral route. Therefore, it was classified in Category 1 (cardiovascular system, nervous system, muscular system, kidney).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information