GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 115-90-2
Chemical Name Phosphorothioic acid O,O-diethyl O-(4-methylsulfinylphenyl) (fensulfothion)
Substance ID H26-B-062, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Classification not possible
-
-
- - No data available.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - Because data of water solubility of 0.15 g/100 mL (25 deg C) (ICSC (2001)) were obtained, it is estimated that it does not react vigorously with water.
13 Oxidizing liquids Classification not possible
-
-
- - It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 1


Danger
H300 P301+P310
P361+P364
P264
P270
P321
P330
P405
P501
There are multiple LD50 values for rats, 10.5 mg/kg (male) (ACGIH (7th, 2005)), 1.8-2.3 mg/kg (female), 3.96-10.5 mg/kg (male) (JMPR (1972)), 1.8-10.2 mg/kg (PATTY (5th, 2001)) and 3.5 mg/kg (PIM G001 (1998)). According to the GHS Classification Guidance for the Japanese government, it was classified in Category 1 to which most of the reports correspond.
1 Acute toxicity (Dermal) Category 1


Danger
H310 P302+P352
P262
P264
P270
P280
P310
P321
P361
P364
P405
P501
Based on the reports of LD50 values of 3.5 mg/kg (female), 4.1 mg/kg (female), 19 mg/kg (male), 30.0 mg/kg (male) (ACGIH (7th, 2005)), 3.5-13 mg/kg (female), 14-30 mg/kg (male) (JMPR (1972)) for rats, it was classified in Category 1.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 1


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on the reports of LC50 (4 hours) values of 0.0295 mg/L (ACGIH (7th, 2005), PATTY (5th, 2001)) and 0.030 mg/L (JMPR (1972)) for rats, it was classified in Category 1. Besides, since LC50 values were higher than the saturated vapor concentration (0.000832 mg/L), the reference value of the mist was applied.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, although there is a description that in humans this substance may show skin irritation in contact with skins (HSDB (Access on July 2014)), because it is a general description, it was not adopted for classification.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, although there is a description that organophosphorus pesticides cause chronic conjunctivitis and keratitis in contact with the eyes (HSDB (Access on July 2014)), because it is a general description, it was judged to be insufficient data for classification.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse dominant lethal test (JMPR (1982), HSDB (Access on August 2014)). As for in vitro, it was negative in a bacterial reverse mutation test and a sister chromatid exchange test with cultured mammalian cells (JMPR (1982), ACGIH (7th, 2005), HSDB (Access on August 2014)).
6 Carcinogenicity Classification not possible
-
-
- - Since it is classified as A4 by ACGIH (ACGIH (7th, 2005)), it was classified as "Classification not possible." The classification was revised due to the change in the GHS classification guidance for the Japanese government.
7 Reproductive toxicity Not classified
-
-
- - It is reported that there were no effects on fertility of the parents and on development and growth of pups in a three-generation reproductive toxicity study by feeding with mice, that there were no teratogenicity in the teratogenicity studies by oral administration (feeding or gavage) with rabbits, and that no effects on fertility were observed in a reproductive toxicity study by inhalation with rats (ACGIH (7th, 2005), JMPR (1972) JMPR (1982)). Therefore, it was classified as "Not classified."
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
This substance has a cholinesterase inhibiting effect (ACGIH (7th, 2005), HSDB (Access on August 2014)). In humans, it is reported that bradycardia, hypotension, seizures, convulsion, respiratory insufficiency, weakness, coma were seen in oral or dermal exposure, and though the route of exposure was not described, nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, convulsions, disorientation, miosis, weakness, paralysis, coma, dyspnea, rale, bronchorrhea, bronchospasm, tachypnea, respiratory insufficiency, chemical pneumonitis, and as a severe case, non-cardiogenic pulmonary edema are observed (ACGIH (7th, 2005), HSDB (Access on August 2014)). In experimental animals, oral administration of 550 mg/kg to rats caused loss of righting ability (ACGIH (7th, 2005)).
From the above, since effects on the nervous system and respiratory organs are seen in humans, it was classified in Category 1 (nervous system, respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system)


Danger
H372 P260
P264
P270
P314
P501
There are no hazard findings in humans. In experimental animals, in each study in which the substance was administered by feeding to rats for 17 months and to dogs for 12 weeks or 2 years, serum, red blood cell, and brain cholinesterase activities were inhibited from concentrations of 1-2 ppm (corresponding to 0.025-0.05 mg/kg/day) in feed, and at the higher dose (5 ppm), cholinergic poisoning symptoms (although there is no specific description, it is speculated that miosis, tremor, convulsions, etc. were observed), weight loss and mortality occurred (JMPR (1972), ACGIH (7th, 2005)). In addition, in a study in which rats were exposed to this substance (presumed to be the mist) by inhalation for 12 weeks, inhibition of cholinesterase at 0.818 mg/m3 (0.00076 mg/L/6 hours), and poisoning symptoms, weight loss and mortality at 7.21 mg/m3 (0.0067 mg/L/6 hours) occurred (JMPR (1982), ACGIH (7th, 2005)).
From the above, in experimental animals through both the oral and inhalation routes, neurotoxicity due to cholinesterase inhibition occurred from doses within the range of Category 1, and in severe cases, death was shown. Therefore, it was classified in Category 1 (nervous system).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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